This has increased the therapeutic efficacy and safety profiles of these medicines, resulting in significant nucleic acid therapeutics market development.

WILMINGTON, Del., Aug. 1, 2024 /PRNewswire/ -- According to Transparency Market Research, the scope for nucleic acid therapeutics is immense in the forthcoming decade. With an astounding CAGR of 12.8%, the market is forecast to attain a valuation of US$ 22.1 billion by 2034. As of 2023, the nucleic acid therapeutics landscape was valued at US$ 6 billion.

Advances in genetic research and biotechnology are propelling the nucleic acid therapeutics market value. These medicines, which include antisense oligonucleotides (ASOs), RNA interference (RNAi), and RNA aptamers, provide targeted treatments for a range of genetic abnormalities, infectious diseases, and malignancies.

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ASOs have the largest market share due to their strong therapeutic properties; they are effective in treating rare genetic disorders such as Duchenne muscular dystrophy and spinal muscular atrophy. RNAi medicines, with their great specificity in gene silencing, are expected to witness substantial market progress, fueled by successful drugs such as patisiran and givosiran. RNA aptamers, albeit being rare, show great potential because of their unique targeting capabilities.

The creation of synthetic oligonucleotides has resulted in substantial advances in nucleic acid treatments. To improve their medicinal capabilities, synthetic oligonucleotides undergo certain chemical changes. These alterations can take place at three different sites: the nucleobase, the ribofuranose unit, and the phosphate backbone.

Altering the nucleobase and ribose units can shield oligonucleotides against enzymatic damage, thus enhancing their stability within the body, whereas modification of the phosphate backbone can make nucleotide chains less negatively charged, thus promoting their cellular uptake and target localization.

Nucleic Acid Therapeutics Market Report Scope:

Competitive Landscape

The market for nucleic acid therapeutics is highly competitive and has a strong presence of key players. The nucleic acid therapeutics market report highlights that leading players are adopting strategies such as acquisition and launch of new products. Key players operating in the nucleic acid therapeutics domain include:

• Alynylam Pharmaceutials Inc.
• BioNTech
• Ionis Pharmaceuticals Inc.
• Moderna
• Nippon Shinyaku
• Novartis
• Pfizer
• Sarepta Therapeutics
• Biogen Inc.
• Genzyme Sanofi
• Percheron Therapeutics Ltd.
• Other Prominent Players

Key Market Developments

• In April 2024, autogene cevumeran, an RNA-based cancer treatment that stimulates the immune system to target and kill pancreatic cancer cells, was investigated in a clinical trial by the Memorial Sloan Kettering Cancer Center. This stops existing cancer as well as avoids more illness with the help of a strong immune system.
• In December 2023, Ionis Pharmaceuticals expanded its Carlsbad's facility for improving its nucleotide-based therapeutics capabilities, expecting support for product investment as well as clinical trials so as bring in more innovative nucleotide drugs into the market, which constitutes the main theme of its antisense technology.

Key Takeaways from the Market Report

• In 2024, the nucleic acid therapeutics market is expected to total US$ 6.8 billion.
• From 2024 to 2034, the market is anticipated to expand 3.2x.
• By product, demand for anti-sense oligonucleotides (ASO) is expected to be high, attributed to their capacity to specifically target and modify gene expression.
• By indication, genetic disorders are expected to be primary areas for nucleic acid therapeutics.

Key Market Drivers and Trends

• Modifications of chemical structure of genes address the fundamental constraints of native oligonucleotides, which include low stability and poor physicochemical characteristics.
• As a result, these changes vividly improve the pharmacokinetic characteristics of oligonucleotide-based treatments, making them more promising for clinical usage.
• Because of their increased stability and efficiency, nucelic acid based drugs can now be used to treat a wide spectrum of ailments, including genetic abnormalities and malignancies.
• Hence, improved efficacy and safety profiles of the new synthetic oligonucleotides and innovative gene editing technologies are fueling the nucleic acid therapies market size.

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Regional Profile

• North America promises to yield significant expansion opportunities for nucleic acid therapeutics. Excellent research and development infrastructure, robust regulatory environment, and high prevalence of genetic abnormalities and diseases treated with these therapies are driving market dynamics.
• The United States, in particular, is home to prominent biotechnology and pharmaceutical businesses that invest in cutting-edge technologies such as CRISPR-Cas gene editing and synthetic oligonucleotides. The region's well-established regulatory system, which includes clear standards from agencies such as the FDA, promotes innovation and supports the timely launch of innovative treatments.
• Good legislation and more clinical trials are driving the nucleic acid therapeutics market revenue in Europe. Furthermore, with improved technology and access to better healthcare, Asia Pacific is becoming a lucrative market.

Key Segments Profiled

Product

• Anti-sense Oligonucleotides (ASO)
• RNA Interference (RNAi)
• RNA Aptamers

Indication

• Autoimmune Disorders
• Infectious Diseases
• Genetic Disorders
• Cancer
• Others (Neurodegenerative Diseases, etc.)

End User

• Hospitals
• Physicians' Offices
• Others (Academics and Research Institutes, etc.)

Region

• North America
• Latin America
• Europe
• Asia Pacific
• Middle East & Africa 

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