In this free webinar, learn the methodological considerations involved in using real-world comparator cohorts (RWCCs) in clinical trials. Attendees will learn strategies for designing and conducting robust RWCC studies that minimize bias and confounding. The featured speaker will discuss how to leverage real-world data to generate high-quality evidence for clinical decision-making.

TORONTO, July 31, 2024 /PRNewswire-PRWeb/ -- Real-world comparator cohorts (RWCC) are increasingly being used in clinical trials as synthetic controls particularly in rare and complex disease populations and in settings where randomized controlled trials (RCTs) are infeasible or unethical. While RWCCs offer potential benefits such as increased efficiency, reduced costs and improved generalizability, their use also raises methodological challenges.

While RWCCs offer potential benefits such as increased efficiency, reduced costs and improved generalizability, their use also raises methodological challenges.

This webinar will delve into methodological considerations surrounding the use of RWCCs in clinical trials, covering topics such as:

  • Role in Clinical Research: Reviewing the importance/applications of RWCCs in clinical research
  • Study Design: How to select appropriate RWCCs, considering factors such as data source, inclusion/exclusion criteria and potential biases
  • Data Sources: Understanding the strengths and limitations of different real-world data sources, including electronic health records, claims data and patient registries and explore approaches for pooling data from various sources
  • Statistical Analysis: Exploring appropriate statistical methods for analyzing RWCC data, including propensity score matching, regression adjustment and instrumental variable analysis
  • Bias and Confounding: Identifying and addressing potential sources of bias and confounding in RWCC studies such as selection bias, measurement error and unmeasured confounding
  • Case Example: Examine a real-world example of successful use of RWCCs in clinical trials, highlighting best practices and lessons learned

Register now for this webinar focusing on the use of real-world comparator cohorts in clinical trials and their growing role in research.

Join Kitty Rajagopalan, PhD, President & Chief Scientific Officer, Anlitiks, for the live webinar on Thursday, August 22, 2024, at 12pm EDT (6pm CEST/EU-Central).

For more information, or to register for this event, visit Leveraging Real-World Comparator Cohorts in Clinical Trials: A Methodological Deep Dive.

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Vera Kovacevic
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