ID Biomedical (NASDAQ:IDBE)
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ID Biomedical begins development of pandemic influenza vaccine
VANCOUVER, Jan. 19 /PRNewswire-FirstCall/ -- ID Biomedical Corporation (TSX:
IDB; NASDAQ: IDBE) announced today that it has begun development of an
experimental ("mock") vaccine against a strain of the influenza virus, H5N1,
that experts believe could cause a deadly worldwide epidemic (pandemic) of
influenza. The H5N1 strain is a new strain of influenza virus that humans have
little or no resistance to and has resulted in high rates of illness and death.
ID Biomedical's development efforts will concentrate on creating a vaccine
using a genetically modified variant of the H5N1 strain.
Since January 2004, sporadic outbreaks of highly pathogenic bird (avian)
influenza caused by an H5N1 influenza strain have occurred in South East Asia.
Occasional transmission of the virus directly from birds to human has resulted
in a high mortality rate in those infected. To date, all humans infected have
contracted the virus directly from birds and there is no conclusive evidence of
human to human transmission that could lead to an influenza pandemic.
ID Biomedical has obtained the genetically modified rH5N1 reference strain from
the National Institute for Biological Standards and Control (NIBSC) in the U.K.
NIBSC is one of the few World Health Organization (WHO) selected laboratories
in the world, which conducts experimental work aimed at producing pandemic
reference strains for potential vaccine production.
The reverse genetics technology used by NIBSC allows the rH5N1 strain to be
grown in chicken eggs, an important source of influenza vaccine production.
Typically, because of their virulence, pandemic avian strains kill eggs,
therefore making it impossible to produce a vaccine from this source. The
genetic modification of the virus also weakens its virulence so that it is no
more dangerous than the influenza strains used by manufacturers during annual
influenza production.
The initial objective of the Company's development program is to optimize the
conditions under which the rH5N1 virus grows in eggs and to develop a virus
seed bank for future vaccine production. The work will be conducted by ID
Biomedical at its Quebec manufacturing facility. The second phase of this
pandemic preparedness program is to produce a "mock" vaccine in sufficient
quantities to conduct clinical trials. ID Biomedical is currently in
discussions with the Canadian Government with regard to funding this important
program.
"The successful completion of this development program will position Canada and
ID Biomedical as worldwide leaders in pandemic preparedness. There is a growing
consensus among experts supported by the WHO that the development and testing
of a mock pandemic vaccine is a critical component of pandemic preparedness
because it will allow manufacturers to shorten production times, thereby
providing the general public with vaccine more quickly. The speed at which we
will make the vaccine available to people will have a direct impact on the
number of lives saved. We are very proud to be the official Canadian pandemic
vaccine supplier and to be at the forefront of the preparedness work," said
Anthony Holler, M.D., Chief Executive Officer of ID Biomedical.
In October 2001, the Company announced that it had signed a ten-year contract
with the Canadian Government to assure a state of readiness in case of an
influenza pandemic. The contract requires that ID Biomedical develop the
infrastructure and capacity, in Canada, to provide 100 % of domestic vaccine
needs in the event of an influenza pandemic. To fulfill its commitments to this
contract, ID Biomedical is currently completing an expansion of its production
facility, has secured a year-round supply of eggs and has stockpiled raw
materials and supplies necessary to permit rapid vaccine production.
About Influenza and Pandemics
Each year, the World Health Organization identifies the influenza strains
expected to be circulating worldwide. It then recommends which three flu
strains should be incorporated into the annual vaccine. The new strains are
then distributed to vaccine producers who manufacture the appropriate trivalent
vaccine for the year. Periodically, an entirely different strain of flu virus
emerges that is more pathogenic to the respiratory system of humans. This can
cause an influenza pandemic because the human immune system has little or no
defense against the new virus. In such cases, the rapid production of a new
pandemic flu vaccine is the best method of providing protection to the
population.
Influenza pandemics are cyclical. In the twentieth century, there were three
influenza pandemics: the Spanish flu in 1918, which claimed at least 20 million
lives, the Asian flu in 1957, that killed more than 70,000 North Americans and
the Hong Kong flu in 1968 which was responsible for the deaths of 34,000 people
in North America.
About ID Biomedical
ID Biomedical is an integrated biotechnology company dedicated to the
development of innovative vaccine products. It operates in research,
development, manufacturing, sales and marketing from its facilities in Canada
and in the United States. ID Biomedical is dedicated to becoming a premier
vaccine company with significant marketed products worldwide and an extensive
pipeline in both clinical and preclinical development.
ID Biomedical has a leading position in the Canadian influenza market. It
received a ten-year mandate from the Government of Canada in 2001 to assure a
state of readiness in the case of an influenza pandemic and provide influenza
vaccine for all Canadians in such an event. It also currently supplies
approximately 75% of the Canadian government's influenza vaccine purchases.
For further information on ID Biomedical, please visit the Company's website at
http://www.idbiomedical.com/.
The information in this news release contains so-called "forward-looking"
statements. These include statements regarding ID Biomedical's expectations and
plans relating to the closing of the loan transaction and the repurchase of the
subscription receipts described herein, statements about ID Biomedical's
expectations, beliefs, intentions or strategies for the future, which may be
indicated by words or phrases such as "anticipate", "expect", "intend", "plan",
"will", "we believe", "ID Biomedical believes", "management believes", and
similar language. All forward-looking statements are based on ID Biomedical's
current expectations and are subject to risks and uncertainties and to
assumptions made. Important factors that could cause actual results to differ
materially from those expressed or implied by such forward-looking statements
include: (i) the company's ability to successfully integrate the Shire vaccine
business; (ii) the company's ability to successfully complete preclinical and
clinical development of its products; (iii) the company's ability to
manufacture its products; (iv) the seasonality of the flu-vaccine business and
related fluctuations in the company's revenues from quarter to quarter; (v)
decisions, and the timing of decisions, made by the health regulatory agencies
regarding approval of its products for human testing; (vi) the company's
ability to enter into distribution agreements for its products, and to complete
and maintain corporate alliances relating to the development and
commercialization of its technology and products; (vii) market acceptance of
its technologies and products; and (viii) the competitive environment and
impact of technological change and other risks detailed in the company's
filings with the Securities and Exchange Commission. ID Biomedical bases its
forward-looking statements on information currently available to it, and
assumes no obligation to update them.
For further information, please contact:
Investor Relations / Media:
Dean Linden
(604) 431-9314
Michele Roy
(450) 978-6313
DATASOURCE: ID Biomedical Corporation
CONTACT: Investor Relations / Media: Dean Linden, (604) 431-9314,
; Michele Roy, (450) 978-6313,
;
To request a free copy of this organization's annual report, please go to
http://www.newswire.ca/ and click on reports@cnw.