RNS Number:2606T
Cobra Bio-Manufacturing PLC
15 December 2003

                                  SCHEDULE 10

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES


1.     Name of company

       Cobra Bio-Manufacturing plc

2.     Name of shareholder having a major interest

       INVESCO English and International Trust plc

3.     Please state whether notification indicates that it is in respect of holding of the shareholder named in 2 above
       or in respect of a non-beneficial interest or in the case of an individual holder if it is a holding of that
       person's spouse or children under the age of 18.

       As above

4.     Name of the registered holder(s) and, if more than one holder, the number of shares held by each of them

       Chase Nominees Limited

5.     Number of shares/amount of stock acquired

       58,986

6.     Percentage of issued class

       Not stated

7.     Number of shares/amount of stock disposed

       N/A

8.     Percentage of issued class

       N/A

9.     Class of security

       Ordinary Shares of 10p each

10.    Date of transaction

       10th December 2003

11.    Date company informed

       11th December 2003

12.    Total holding following this notification

       1,173,349 Ordinary Shares

13.    Total percentage holding of issued class following this notification

       6.01%

14.    Any additional information

15.    Name of contact and telephone number for queries

       Tracey Pughe  - Tel: 01782 714181

16.    Name and signature of authorised company official responsible for making this notification.

       Tracey Pughe

Date of notification: 15th December 2003




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