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Share Name | Share Symbol | Market | Type | Share ISIN | Share Description |
---|---|---|---|---|---|
Circio Holding Asa | LSE:0RIS | London | Ordinary Share | NO0013033795 | CIRCIO HOLDING ORD SHS |
Price Change | % Change | Share Price | Bid Price | Offer Price | High Price | Low Price | Open Price | Shares Traded | Last Trade | |
---|---|---|---|---|---|---|---|---|---|---|
0.00 | 0.00% | 15.98 | 0.00 | 01:00:00 |
Industry Sector | Turnover | Profit | EPS - Basic | PE Ratio | Market Cap |
---|---|---|---|---|---|
Home Health Care Services | 10M | -432.9M | -2.2969 | -6.96 | 3.01B |
- Combination of ONCOS-102 and Keytruda reduces size of non-injected tumors
- In vivo proof-of-concept of ONCOS-102 ability to generate systemic anti-tumor responses
OSLO, Norway, June 3, 2019 /PRNewswire/ -- Targovax ASA (OSE: TRVX), a clinical stage biotechnology company developing immune activators to target hard-to-treat solid tumors, today announces that a study showing abscopal effect of ONCOS-102 and Keytruda combination treatment in a humanized mouse melanoma model has been accepted for publication in the Journal of Medical Virology.
Targovax has previously published anti-tumor efficacy of ONCOS-102 as monotherapy as well as synergy with both chemotherapy and checkpoint inhibitors in mouse models. It has also been demonstrated in several different animal models how ONCOS-102 induces robust immune responses and can generate de novo tumor specific T-cells recognizing relevant cancer antigens.
In this latest publication, Targovax has been able to build on the previous immune activation and anti-tumor findings by showing that the combination of ONOCS-102 and Keytruda can generate systemic responses that reduce the size of non-injected lesions. The work was performed in a humanized melanoma mouse model with tumors inoculated dorsally on both sides of the animals. After the tumors were established, ONCOS-102 was injected directly into the tumor on one side only, followed by systemic treatment with Keytruda. By Day 40, tumors on the non-injected side of the animals had shrunk by an average of 70%. This confirms the hypothesis that ONCOS-102 is able to generate systemic immune responses, which can lead to abscopal anti-tumor effect of distal lesions that have not been injected with the virus.
Magnus Jäderberg, Chief Medical Officer of Targovax, said: "This in vivo demonstration of abscopal effect is an important validation of the proposed mechanism of action of ONCOS-102. By injecting the virus intra-tumorally, we see not only a local oncolytic effect at the injection site, but also a reduction of tumors in other locations. As such, these findings provide an in vivo proof-of-concept of ONCOS-102's ability to generate systemic anti-cancer immune responses"
Publication title: Abscopal effect when combining oncolytic adenovirus and checkpoint inhibitor in a humanized NOG mouse model of melanoma
Link: https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.25501
For further information, please contact:
Renate Birkeli
Investor Relations
Phone: +47-922-61-624
Email: renate.birkeli@targovax.com
Media and IR enquires:
Andreas Tinglum
Corporate Communications (Norway)
Phone: +47-9300-1773
Email: andreas.tinglum@corpcom.no
This information was brought to you by Cision http://news.cision.com
https://news.cision.com/targovax/r/targovax-announces-publication-of-in-vivo-abscopal-effect-of-oncos-102-and-keytruda-combination,c2830521
Copyright 2019 PR Newswire
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