Holding(s) in Company

    RNS Number : 6139I
  Protherics PLC
  20 November 2008
   

    Protherics PLC

    Notification of Major Interests in Shares


    London, UK; Brentwood, TN, US: 20 November 2008 - Protherics PLC ("Protherics" or the "Company"), the international biopharmaceutical
company focused on critical care and cancer, announces that, on 19 November 2008, in accordance with the Transparency Obligations Directive,
a notification of interest in the ordinary share capital of the Company was received from AXA Investment Managers UK Limited on behalf of
AXA S.A. and its Group Companies ("AXA").  Details of the interest notified are set out below.


 1.    Reason for the notification (please tick the
 appropriate box or boxes)    


 An acquisition of voting rights                                X
 An acquisition or disposal of financial instruments
 which may result in the acquisition of shares
 already issued to which voting rights are attached

 An event changing the breakdown of voting rights

 Other (please specify)
 2. Full name of person(s)       AXA S.A., 25 Avenue Matignon, 75008 Paris
 subject to the notification            and its group of companies.
 obligation:
 3. Full name of shareholder(s)
 (if different from 2.):
 4. Date of the transaction                   18 November 2008
 (and date on which the
 threshold is crossed or
 reached if different):
 5. Date on which issuer                      19 November 2008
 notified:
 6. Threshold(s) that is/are                        12%
 crossed or reached:

 7. Notified details:


 A: Voting rights attached to shares
 Class/type of shares            Situation previous to the Triggering        Resulting situation after the triggering transaction
 if possible using the ISIN      transaction 
 CODE
                                 Number of Shares      Number of Voting      Number of shares   Number of voting       % of voting
                                                       Rights                                   rights                 rights
                                                                             Direct             Direct     Indirect    Direct  Indirect

 0702920                         42,026,712            42,026,712            1,041,666          1,041,666  41,322,546  0.30%   11.79%


 B: Financial Instruments
 Resulting situation after the triggering transaction 
 Type of financial instrument   Expiration date   Exercise/ Conversion  Number of voting      % of voting rights
                                                  Period/ Date          rights that may be
                                                                        acquired if the
                                                                        instrument is
                                                                        exercised/
                                                                        converted. 



 Total (A+B)
 Number of voting rights  % of voting rights

       42,364,212               12.09%

 8. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable
 :
      Name of Company/Fund                               Number of Shares                                % of issued share capital

 AXA                                                                716,666                                                0.20451   
 Direct

 AXA Framlington                                                 41,322,546                                                  11.79204
 Indirect

 AXA IM UK                                                          325,000                                                   0.09274
 Direct


                   Total Direct                                   1,041,666                                                   0.29726
                 Total Indirect                                  41,322,546                                                  11.79204

                          TOTAL                                  42,364,212                                                  12.08930









 Proxy Voting:
 9. Name of the proxy holder:
 10. Number of voting rights proxy holder will cease
 to hold:
 11. Date on which proxy holder will cease to hold
 voting    rights:

 12. Additional information:  


    | Ends |


    For further information please contact:

 Protherics 
 Nick Staples, Director of Corporate Affairs  [phone]  
 Julie Vickers, Company Secretary             [phone]

 Financial Dynamics - press enquiries
 London: Ben Atwell, Lara Mott                [phone] 
 New York: John Capodanno                     [phone]

    Or visit  www.protherics.com

This information is provided by RNS
The company news service from the London Stock Exchange
 
  END 
 
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