Holding(s) in Company

    SCHEDULE 10                                  
                                                                               
                   NOTIFICATION OF MAJOR INTERESTS IN SHARES                   

1. Name of company

Acambis plc                                                                    

2. Name of shareholder having a major interest

Morley Fund Management Limited (a subsidiary of Aviva plc)                     

3. Please state whether notification indicates that it is in respect of holding
of the shareholder named in 2 above or in respect of a non-beneficial interest
or in the case of an individual holder if it is a holding of that person's
spouse or children under the age of 18

As above                                                                       

4. Name of the registered holder(s) and, if more than one holder, the number of
shares held by each of them

BNY Norwich Union Nominees Ltd 1,462,266 shares                                
                                                                               
Chase GA Group Nominees Ltd 3,853,279 shares                                   
                                                                               
Chase Nominees Ltd 323,474 shares                                              
                                                                               
CUIM Nominees Ltd 1,726,925 shares                                             
                                                                               
RBSTB Nominees Ltd 185,983 shares                                              
                                                                               
BNY (Nomines) Ltd 416,993 shares                                               
                                                                               
Chase Nominees Ltd 762,600 shares                                              
                                                                               
CUIM Nominee Ltd 154,940 shares                                                
                                                                               
Vidacos Nominees Ltd 2,282,703 shares                                          

5. Number of shares / amount of stock acquired

4,995,600 shares                                                               

6. Percentage of issued class

4.73%                                                                          

7. Number of shares / amount of stock disposed

N/a                                                                            

8. Percentage of issued class

N/a                                                                            

9. Class of security

Ordinary shares of 10p each                                                    

10. Date of transaction

19 December 2003                                                               

11. Date company informed

22 December 2003                                                               

12. Total holding following this notification

11,169,163 shares                                                              

13. Total percentage holding of issued class following this notification

10.57%                                                                         

14. Any additional information

N/A                                                                            

15. Name of contact and telephone number for queries

Elizabeth Brown, Company Secretary                                             
                                                                               
[phone]                                                           

16. Name and signature of authorised company official responsible for making
this notification

Elizabeth Brown                                                                

Date of notification

23 December 2003                                                               

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END