Holding(s) in Company

    SCHEDULE 10                                  
                                                                               
                   NOTIFICATION OF MAJOR INTERESTS IN SHARES                   

1. Name of company

Acambis plc                                                                    

2. Name of shareholder having a major interest

Standard Life Investments                                                      

3. Please state whether notification indicates that it is in respect of holding
of the shareholder named in 2 above or in respect of a non-beneficial interest
or in the case of an individual holder if it is a holding of that person's
spouse or children under the age of 18

As above                                                                       

4. Name of the registered holder(s) and, if more than one holder, the number of
shares held by each of them

The legal entities holding these shares are as follows:                        
                                                                               
Stanlife Nominees Limited 3,471,484 shares                                     

5. Number of shares / amount of stock acquired

558,823 shares                                                                 

6. Percentage of issued class

0.53%                                                                          

7. Number of shares / amount of stock disposed

N/A                                                                            

8. Percentage of issued class

N/A                                                                            

9. Class of security

Ordinary shares of 10p each                                                    

10. Date of transaction

19 December 2003                                                               

11. Date company informed

22 December 2003                                                               

12. Total holding following this notification

3,471,484 shares                                                               

13. Total percentage holding of issued class following this notification

3.29%                                                                          

14. Any additional information

N/A                                                                            

15. Name of contact and telephone number for queries

Elizabeth Brown tel: [phone]                                              

16. Name and signature of authorised company official responsible for making
this notification

Elizabeth Brown, Company Secretary                                             

Date of notification

22 December 2003                                                               

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END