Statement of Changes in Beneficial Ownership (4)

FORM 4 [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES	OMB APPROVAL OMB Number: 3235-0287 Estimated average burden hours per response... 0.5
	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person * SABBY MANAGEMENT, LLC	2. Issuer Name and Ticker or Trading Symbol Rosetta Genomics Ltd. [ ROSG ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director                      __ X __ 10% Owner _____ Officer (give title below)      _____ Other (specify below)
(Last)          (First)          (Middle) 10 MOUNTAINVIEW ROAD, SUITE 205	3. Date of Earliest Transaction (MM/DD/YYYY) 3/14/2018
(Street) UPPER SADDLE RIVER, NJ 07458 (City)        (State)        (Zip)	4. If Amendment, Date Original Filed (MM/DD/YYYY)	6. Individual or Joint/Group Filing (Check Applicable Line) ___ Form filed by One Reporting Person _ X _ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	3. Trans. Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
ADR Shares (each one equal to 2 ordinary shares)	3/14/2018		P		800	A	$0.4199	751349	I   (1) (2)	See Footnotes   (1) (2)
ADR Shares (each one equal to 2 ordinary shares)	3/14/2018		P		4271	A	$0.42	755620	I   (1) (2)	See Footnotes   (1) (2)
ADR Shares (each one equal to 2 ordinary shares)	3/14/2018		P		200	A	$0.42	755820	I   (1) (2)	See Footnotes   (1) (2)
ADR Shares (each one equal to 2 ordinary shares)	3/14/2018		P		17900	A	$0.424	773720	I   (1) (2)	See Footnotes   (1) (2)
ADR Shares (each one equal to 2 ordinary shares)	3/14/2018		P		50020	A	$0.4201	823740	I   (1) (2)	See Footnotes   (1) (2)
ADR Shares (each one equal to 2 ordinary shares)	3/15/2018		P		15025	A	$0.4205	838765	I   (1) (2)	See Footnotes   (1) (2)
ADR Shares (each one equal to 2 ordinary shares)	3/15/2018		P		34	A	$0.42	838799	I   (1) (2)	See Footnotes   (1) (2)
ADR Shares (each one equal to 2 ordinary shares)	3/15/2018		P		3566	A	$0.42	842365	I   (1) (2)	See Footnotes   (1) (2)
ADR Shares (each one equal to 2 ordinary shares)	3/15/2018		P		13545	A	$0.42	855910	I   (1) (2)	See Footnotes   (1) (2)
ADR Shares (each one equal to 2 ordinary shares)	3/15/2018		P		14400	A	$0.4205	870310	I   (1) (2)	See Footnotes   (1) (2)

Table II - Derivative Securities Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	4. Trans. Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:
(1)	This Form 4 is being filed by Sabby Healthcare Master Fund, Ltd. ("SHMF"), Sabby Volatility Warrant Master Fund, Ltd. ("SVWMF"), Sabby Management, LLC ("Advisor") and Hal Mintz. Advisor is the investment manager of SHMF and SVWMF. Mr. Mintz is manager of Advisor.
(2)	The amounts reported herein reflect the entire amount of Issuer's ADR shares held by SHMF and SVWMF as of each transaction date. Each of Advisor and Mr. Mintz disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934 ("Section 16"), beneficial ownership of such securities, except to the extent of its/his pecuniary interest therein, and this report shall not be deemed as an admission that either Advisor or Mr. Mintz is the beneficial owner of such securities for purposes of Section 16 or otherwise.

Reporting Owners
Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
SABBY MANAGEMENT, LLC 10 MOUNTAINVIEW ROAD SUITE 205 UPPER SADDLE RIVER, NJ 07458		X
Sabby Healthcare Master Fund, Ltd. C/O SABBY MANAGEMENT, LLC 10 MOUNTAINVIEW ROAD, SUITE 205 UPPER SADDLE RIVER, NJ 07458		X

Signatures
/s/ Robert Grundstein, COO and General Counsel of Sabby Management, LLC		3/16/2018
** Signature of Reporting Person		Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note:	File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
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