- Amended Statement of Ownership (SC 13G/A)

	DOCUMENT TYPE SC 13G/A

	TEXT

	SECURITIES AND EXCHANGE COMMISSION

	Washington, D.C. 20549

	SCHEDULE 13G

	Under the Securities Exchange Act of 1934

	Amendment # 2

	Name of Issuer: ARYX Therapeutics, Inc.

	_____________________________________________________

	Title of Class

	of Securities: Common Stock

	CUSIP Number: 043387109

	1) NAME AND I.R.S. IDENTIFICATION NO. OF REPORTING PERSON

	Prudential Financial, Inc. 22-3703799

	2.) MEMBER OF A GROUP: (a) N/A

	(b) N/A

	3) SEC USE ONLY:

	4) PLACE OF ORGANIZATION: New Jersey

	NUMBER OF SHARES BENEFICIALLY OWNED BY REPORTING PERSON WITH:

	5) Sole Voting Power: Not
	Applicable

	6) Shared Voting Power: Not Applicable

	7) Sole Dispositive Power: Not Applicable

	8) Shared Dispositive Power: Not Applicable

	9) AGGREGATE AMOUNT BENEFICIALLY OWNED:

	Not Applicable

	10) AGGREGATE AMOUNT IN ROW (9) EXCLUDES SHARES: Not Applicable

	11) PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9):

	Not Applicable

	12) TYPE OF REPORTING PERSON: HC

	ITEM 1(a). NAME OF ISSUER:

	ARYX Therapeutics, Inc.

	ITEM 1(b). ADDRESS OF ISSUER'S EXECUTIVE OFFICES:

	ARYX Therapeutics, Inc.
	6300 Dumbarton Circle
	Fremont, CA 94555

	ITEM 2(a). NAME OF PERSON FILING:

	Prudential Financial, Inc.

	ITEM 2(b). ADDRESS OF PRINCIPAL BUSINESS OFFICE:

	751 Broad Street

	Newark, New Jersey 07102-3777

	ITEM 2(c). CITIZENSHIP:

	New Jersey

	ITEM 2(d). TITLE OF CLASS OF SECURITIES:

	Common Stock

	ITEM 2(e). CUSIP NUMBER:

	043387109

	ITEM 3. The Person filing this statement is a Parent Holding
	Company as

	defined in Section 240.13d-1(b)(1)(ii)(G) of the Securities
	Exchange

	Act of 1934.

	ITEM 4. OWNERSHIP:

	(a) Number of Shares

	Beneficially Owned: Not Applicable

	(b) Percent of Class:

(c) Powers No. Of Shares

 ----------- -------------------- 

Sole power to vote or Not Applicable
to direct the vote

Shared power to vote or Not Applicable
to direct the vote

Sole power to dispose or Not Applicable
to direct disposition

Shared power to dispose Not Applicable
or to direct disposition

	ITEM 5. OWNERSHIP OF 5% OR LESS OF A CLASS:

	Prudential Financial, Inc. through its beneficial ownership of
	the Item 7 listed entities has ceased to be deemed the beneficial owner of more
	than 5% of the outstanding Common Stock of this issuer.

	ITEM 6. OWNERSHIP OF MORE THAN 5% ON BEHALF OF

	ANOTHER PERSON:

	Not Applicable

	ITEM 7. IDENTIFICATION AND CLASSIFICATION OF THE

	SUBSIDIARY WHICH ACQUIRED THE SECURITY BEING

	REPORTED ON BY THE ULTIMATE PARENT COMPANY:

	See Exhibit A

	ITEM 8. IDENTIFICATION AND CLASSIFICATION OF

	MEMBERS OF THE GROUP:

	Not Applicable

	ITEM 9. NOTICE OF DISSOLUTION OF GROUP:

	Not Applicable

	ITEM 10. CERTIFICATION:

By signing below, Prudential Financial, Inc. certifies that, to the best of its
knowledge and belief, the securities referred to above were acquired
and are held in the ordinary course of business and were not acquired
and are not held for the purpose of or with the effect of changing or
influencing the control of the issuer of the securities and were not acquired
and are not held in connection with or as a participant in any transaction
having that purpose or effect.

The filing of this statement should not be construed as an admission that
Prudential Financial, Inc. is, for purposes of Sections 13 or 16 of the Securities
Exchange Act of 1934, the beneficial owner of such shares.

	SIGNATURE

	After reasonable inquiry and to the best of its knowledge and
	belief,

	Prudential Financial, Inc. certifies that the information set forth in this

	statement is true, complete and correct.

	PRUDENTIAL FINANCIAL, INC.

	By: Frank Adamo

	Vice President

	Date: 04/11/2011

	As of: 3/31/2011

	Exhibit A

	--------------

	ITEM 6. OWNERSHIP:

	ITEM 7. IDENTIFICATION/CLASSIFICATION:

	Prudential Financial, Inc. is a Parent Holding Company and the direct or
	indirect parent of the following Registered Investment Advisers and Broker
	Dealers:

 The Prudential Insurance Company of America

 IC,IA

 Prudential Investment Management, Inc.

 IA

 Jennison Associates LLC

 IA

 Prudential Bache Asset Management, Inc.

 IA

 Prudential Investments LLC 

 IA

 Prudential Private Placement Investors, L.P.

 IA,PN

 Pruco Securities, LLC

 IA,BD

 Prudential Investment Management Services LLC

 BD

 AST Investment Services, Inc.

 IA

 Prudential Annuities Distributors, Inc.

 BD

 Quantitative Management Associates LLC

 IA

 Prudential International Investments Advisers, LLC

 IA

 Global Portfolio Strategies, Inc.

 IA

 Prudential Bache Securities, LLC

 BD

 Prudential Bache Commodities, LLC

 BD