Notice of Iran-related Disclosure Filed Pursuant to Section 13(r)(3) of the Exchange Act (irannotice)

February 28, 2023

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U.S. Securities and Exchange Commission

100 F Street N.E.

Washington, DC 20549

Re:	Notice of disclosure filed in Annual Report on Form 20-F under Section 219 of the Iran Threat Reduction and Syria Human Rights Act of 2012 and Section 13(r) of the Securities Exchange Act of 1934

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Ladies and Gentlemen:

Pursuant to Section 219 of the Iran Threat Reduction and Syria Human Rights Act of 2012 and Section 13(r) of the Securities Exchange Act of 1934, as amended, notice is hereby provided that Banco Santander México, S.A., Institución de Banca Múltiple, Grupo Financiero Santander México has made disclosure pursuant to such provisions in its Annual Report on Form 20-F for the fiscal year ended December 31, 2022, which was filed with the U.S. Securities and Exchange Commission on February 28, 2023. This disclosure can be found on pages 157 to 158 of the Annual Report on Form 20-F and is incorporated by reference herein.

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​	Very truly yours,
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​	BANCO SANTANDER MÉXICO, S.A., INSTITUCIÓN DE BANCA MÚLTIPLE, GRUPO FINANCIERO SANTANDER MÉXICO
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​	By:	/s/ Felipe Francisco García Ascencio
​	​	Name:	Felipe Francisco García Ascencio
​	​	Title:	Chief Executive Officer

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