We could not find any results for:
Make sure your spelling is correct or try broadening your search.
Name | Symbol | Market | Type |
---|---|---|---|
AstraZeneca PLC | NYSE:AZN | NYSE | Depository Receipt |
Price Change | % Change | Price | High Price | Low Price | Open Price | Traded | Last Trade | |
---|---|---|---|---|---|---|---|---|
0.00 | 0.00% | 54.17 | 0 | 01:00:00 |
Updated safety data on risk-benefit profile of Farxiga (dapagliflozin), three new analyses from the landmark CVD-REAL study, including Farxiga vs DPP-4 inhibitors, and a late-breaking oral presentation reveal further CV evidence across a broad population of patients with type-2 diabetes
Data from DURATION-7 and DURATION-8 evaluating efficacy and safety of Bydureon (exenatide extended-release) in combination with basal insulin and Farxiga, respectively
More than 50 abstracts demonstrate commitment to Cardiovascular and Metabolic Diseases
AstraZeneca and its global biologics research and development arm, MedImmune, will present the latest research from the Company’s Cardiovascular and Metabolic Diseases (CVMD) therapy area, including for Farxiga (dapagliflozin) and Bydureon (exenatide extended-release) for injectable suspension, with more than 50 abstracts at the American Diabetes Association’s (ADA) 77th Scientific Sessions in San Diego, USA 9-13 June 2017.
Ludovic Helfgott, Vice President, CVMD, said: “Science points to the need to move beyond lowering blood sugar to treat patients with type-2 diabetes holistically and earlier in their disease progression. Through investment in rigorous clinical and real-world evidence studies in large and diverse patient populations, we are committed to advancing scientific understanding of the connections between these highly-prevalent cardiovascular and metabolic diseases and helping to enhance clinical practice to improve the lives of patients.”
Highlights include a comprehensive updated safety analysis of dapagliflozin and three additional analyses from the landmark CVD-REAL real-world evidence study, including CV data for dapagliflozin, evaluating the risk of hospitalization for kidney disease and heart failure (HF), as well as all-cause mortality, compared to DPP-4 inhibitors, a commonly-used treatment for type-2 diabetes (T2D). Additionally, a late-breaking oral presentation will explore the rates of HF and death in patients with T2D, both with and without cardiovascular disease, receiving treatment with SGLT-2 inhibitors (SGLT-2i) versus other T2D medicines.
Also presented will be the baseline characteristics and trial design of DECLARE will be presented, the largest cardiovascular outcomes trial in the SGLT-2i class. Both CVD-REAL and DECLARE are part of the extensive DapaCare programme for dapagliflozin, which involves patients with and without T2D to generate data across established CV disease, CV risk factors and varying stages of renal disease, providing healthcare providers with evidence needed to improve patient care.
AstraZeneca will also present analyses from DURATION-8, evaluating the investigational use of exenatide extended-release in combination with dapagliflozin, as well as primary data from DURATION-7, examining the investigational use of exenatide extended-release in combination with basal insulin.
Notable data being presented by AstraZeneca include:
Real-World Evidence Evaluating CV Outcomes Treatment with SGLT-2 inhibitors
Comprehensive New Safety Analysis of Dapagliflozin
DECLARE Trial Design and Baseline Characteristics
Data Assessing GLP-1 Receptor Agonists with Other Antidiabetic Agents
The full list of AstraZeneca scientific presentations can be accessed on the ADA website here.
Indication and Limitations of Use for FARXIGA® (dapagliflozin)
FARXIGA is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. FARXIGA is not recommended for patients with type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis.
Important Safety Information for FARXIGA® (dapagliflozin)
Contraindications
Warnings and Precautions
Adverse Reactions
In a pool of 12 placebo-controlled studies, the most common adverse reactions (≥5%) associated with FARXIGA 5 mg, 10 mg, and placebo respectively were female genital mycotic infections (8.4% vs 6.9% vs 1.5%), nasopharyngitis (6.6% vs 6.3% vs 6.2%), and urinary tract infections (5.7% vs 4.3% vs 3.7%).
Use in Specific Populations
Please see accompanying US Full Prescribing Information and Medication Guide for FARXIGA.
Indication And Limitations Of Use for BYDUREON® (exenatide extended-release) for injectable suspension
BYDUREON is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus
Important Safety Information for BYDUREON® (exenatide extended-release) for injectable suspension
WARNING: RISK OF THYROID C-CELL TUMORS
CONTRAINDICATIONS
WARNINGS AND PRECAUTIONS
ADVERSE REACTIONS
Most common (≥5%) and occurring more frequently than comparator in clinical trials: nausea (16.9%), diarrhea (12.7%), headache (8.0%), vomiting (6.8%), constipation (5.9%), injection-site pruritus (5.9%), injection-site nodule (5.3%), and dyspepsia (5.1%)
DRUG INTERACTIONS
PREGNANT AND NURSING WOMEN
Please click here for Full Prescribing Information and click here for Medication Guide for BYDUREON 2 mg, including Boxed WARNING.
NOTES TO EDITORS
About the DapaCare Clinical Program
AstraZeneca is taking a holistic, patient-centric approach to disease management by focusing on the underlying morbidity, mortality and organ damage associated with cardiovascular (CV), metabolic and renal diseases. Due to the interconnectivity of these diseases, AstraZeneca has developed the DapaCare clinical programme to explore the CV and renal profile of dapagliflozin in people with and without type-2 diabetes. The clinical programme will enroll nearly 30,000 patients in randomized clinical trials and is supported by a multinational real-world evidence study. DapaCare will generate data across a spectrum of people with established CV disease, CV risk factors and varying stages of renal disease, both with and without type-2 diabetes, providing healthcare providers with evidence needed to potentially improve patient outcomes. DapaCare underscores our commitment to following the science by pursuing a holistic patient approach to address the multiple risk factors associated with CV, metabolic and renal diseases. Dapagliflozin is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes. Dapagliflozin is not indicated for the treatment of other metabolic diseases, to reduce the risk of cardiovascular disease or renal disease.
About AstraZeneca in Cardiovascular & Metabolic Diseases (CVMD)
Cardiovascular, renal and metabolic diseases are key areas of focus for AstraZeneca as part of the company’s strategy for achieving scientific leadership and returning to growth. By collaborating across therapeutic disciplines within the CVMD therapy area, we are addressing the underlying disorders that drive CVMD risk, with the goal of reducing morbidity, mortality and organ damage through innovative therapies. Recognizing the growing unmet needs and challenges faced by the millions of people worldwide living with these interrelated diseases, we are determined to understand how they interact and impact one another – and how they can be treated together to save more patients’ lives.
About AstraZeneca
AstraZeneca is a global, science-led biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines, primarily for the treatment of diseases in three main therapy areas - Oncology, Cardiovascular & Metabolic Diseases and Respiratory. The Company also is selectively active in the areas of autoimmunity, neuroscience and infection. AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide. For more information, please visit www.astrazeneca-us.com and follow us on Twitter @AstraZenecaUS.
US- 10527 Last Updated 5/17
View source version on businesswire.com: http://www.businesswire.com/news/home/20170608005295/en/
AstraZenecaMichele Meixell, +1 302-885-2677orAlex Engel, +1 302-885-2677
1 Year AstraZeneca Chart |
1 Month AstraZeneca Chart |
It looks like you are not logged in. Click the button below to log in and keep track of your recent history.
Support: +44 (0) 203 8794 460 | support@advfn.com
By accessing the services available at ADVFN you are agreeing to be bound by ADVFN's Terms & Conditions