Holding(s) in Company

RNS Number:2925N
British Biotech PLC
08 July 2003


                                  SCHEDULE 10

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES


1. Name of company

British Biotech plc


2. Name of shareholder having a major interest

Amvescap plc


3. Please state whether notification indicates that it is in respect of holding
of the shareholder named in 2 above or in respect of a non-beneficial interest
or in the case of an individual holder if it is a holding of that person's
spouse or children under the age of 18

Notification is in respect of an interest on behalf of discretionary managed
clients of Amvescap plc. By virtue of the Companies Act Section 203 Amvescap is
deemed to have the same interest in the shares


4. Name of the registered holder(s) and, if more than one holder, the number of
shares held by each of them

Vidacos Nominees Ltd                                                 9,774,386
HSBC Nominees Ltd                                                    2,517,726
Chase Nominees Ltd                                                     372,389
Bank of New York Nominees Ltd                                          887,343
Northern Trust Nominees Ltd                                            178,870
CM Investment Nominees Ltd                                               1,718


5. Number of shares / amount of stock acquired

3,405,000


6. Percentage of issued class

5.1 per cent


7. Number of shares / amount of stock disposed

n/a


8. Percentage of issued class

n/a


9. Class of security

Ordinary 5p shares


10. Date of transaction

4 July, 2003


11. Date company informed

7 July, 2003


12. Total holding following this notification

13,732,432 shares


13. Total percentage holding of issued class following this notification

20.57 per cent


14. Any additional information

Amvescap advises that its shareholding includes the following notifiable
holdings, both of which are registered in the name of Vidacos Nominees Ltd:

INVESCO Perpetual High Income Fund, which holds 3,000,403 shares (4.49 per
cent), and;
INVESCO Perpetual UK Growth Fund, which holds 2,090,709 shares (3.13 per cent)


15. Name of contact and telephone number for queries

Tony Weir, Finance Director, + 44 1 865 781166


16. Name and signature of authorised company official responsible for making
this notification

Stephen Powers


Date of notification

8 July, 2003


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                      This information is provided by RNS
            The company news service from the London Stock Exchange

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