Form 3 - Initial statement of beneficial ownership of securities

LIMITED POWER OF ATTORNEY - SECURITIES LAW COMPLIANCE

The undersigned, as an officer or director of OnKure Therapeutics, Inc. (the “Corporation”),

hereby constitutes and appoints Jason Leverone and Rogan Nunn, each the undersigned’s true and

lawful attorney-in-fact and agent to complete and execute such Forms 144, Form ID, Forms 3, 4

and5 and other forms as such attorney shall in his or her discretion determine to be required or

advisable pursuant to Rule 144 promulgated under the Securities Act of 1933, as amended, Section

16 of the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated

thereunder, or any successor laws and regulations, as a consequence of the undersigned’s ownership,

acquisition or disposition of securities of the Corporation, and to do all acts necessary in order to file

such forms with the Securities and Exchange Commission, any securities exchange or national

association, the Corporation and such other person or agency as the attorney shall deem appropriate.

The undersigned hereby ratifies and confirms all that said attorneys-in-fact and agents shall do or

cause to be done by virtue hereof.  The undersigned acknowledges that the foregoing attorneys-in

fact, in serving in such capacity at the request of the undersigned, are not assuming, nor is the

Corporation assuming, any of the undersigned's responsibilities to comply with Section 16 of the

Securities Exchange Act of 1934, as amended.

This Limited Power of Attorney shall remain in full force and effect until the undersigned is no

longer required to file Form 144, and/or Forms 3, 4 and 5 with respect to the undersigned's holdings

of and transactions in securities issued by the Corporation unless earlier revoked by the undersigned

in a writing delivered to the foregoing attorneys-in-fact.

This Limited Power of Attorney is executed as of the date set forth below.

Signature:  /s/ R. Michael Carruthers

Print Name:  R. Michael Carruthers

Dated:  September 18, 2024

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