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| Holder | Type | Held (Actual) | % of Outstanding | Market Value | Date Reported |
|---|---|---|---|---|---|
| Deep Track Capital, LP | Institution | 3,352,804 | 11.69% | US$ 113.12M | 2026-03-31 |
| Deep Track Biotechnology Master Fund, Ltd | Institution | 2,686,138 | 9.37% | US$ 90.63M | 2026-02-06 |
| RA Capital Management, L.P. | Institution | 2,208,604 | 7.70% | US$ 74.52M | 2026-03-31 |
| TCG Crossover Management, LLC | Institution | 1,839,489 | 6.41% | US$ 62.06M | 2026-03-31 |
| TCG Crossover Fund II, L.P. | Institution | 1,839,489 | 6.41% | US$ 62.06M | 2026-03-31 |
| RA Capital Healthcare Fund, L.P. | Institution | 1,675,000 | 5.84% | US$ 56.51M | 2025-09-12 |
| Commodore Capital LP | Institution | 1,500,000 | 5.23% | US$ 50.61M | 2026-03-31 |
| Caligan Partners, LP | Institution | 1,438,070 | 5.01% | US$ 48.52M | 2026-03-31 |
| Pontifax Venture Capital | Institution | 1,411,681 | 4.92% | US$ 47.63M | 2026-03-31 |
| JP Morgan Asset Management | Institution | 1,392,004 | 4.85% | US$ 46.97M | 2026-03-31 |
| Spruce Street Capital LP | Institution | 1,376,159 | 4.80% | US$ 46.43M | 2026-03-31 |
| Trails Edge Capital Partners, LP | Institution | 1,319,362 | 4.60% | US$ 44.52M | 2026-03-31 |
| Commodore Capital Master LP | Institution | 1,225,000 | 4.27% | US$ 41.33M | 2025-09-11 |
| Nantahala Capital Management, LLC | Institution | 1,052,894 | 3.67% | US$ 35.52M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 923,694 | 3.22% | US$ 31.17M | 2026-03-31 |
| Logos Global Management, L.P. | Institution | 915,000 | 3.19% | US$ 30.87M | 2026-03-31 |
| Vida Ventures Advisors, LLC | Institution | 882,243 | 3.08% | US$ 29.77M | 2025-09-12 |
| Vida Ventures III, L.P. | Institution | 882,243 | 3.08% | US$ 29.77M | 2025-09-12 |
| Alyeska Investment Group, L.P. | Institution | 863,947 | 3.01% | US$ 29.15M | 2026-03-31 |
| Vivo Capital, LLC | Institution | 800,000 | 2.79% | US$ 26.99M | 2026-03-31 |
| Pivotal BioVenture Partners LLC | Institution | 630,657 | 2.20% | US$ 21.28M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 518,228 | 1.81% | US$ 17.49M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 363,799 | 1.27% | US$ 12.27M | 2026-03-31 |
| Great Point Partners, LLC | Institution | 300,000 | 1.05% | US$ 10.12M | 2026-03-31 |
| Baker Bros. Advisors LP | Institution | 200,000 | 0.70% | US$ 6.75M | 2026-03-31 |
| HighVista Strategies LLC | Institution | 173,595 | 0.61% | US$ 5.86M | 2026-03-31 |
| Calamos Advisors LLC | Institution | 157,655 | 0.55% | US$ 5.32M | 2026-04-30 |
| PGIM Securities Investment Trust Enterprise | Institution | 151,417 | 0.53% | US$ 5.11M | 2026-03-31 |
| Integral Health Asset Management, LLC | Institution | 150,000 | 0.52% | US$ 5.06M | 2026-03-31 |
| UBS Asset Management AG | Institution | 137,932 | 0.48% | US$ 4.65M | 2026-03-31 |
| Millennium Management LLC | Institution | 136,966 | 0.48% | US$ 4.62M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 112,497 | 0.39% | US$ 3.80M | 2026-03-31 |
| Columbia Management Investment Advisers, LLC | Institution | 108,307 | 0.38% | US$ 3.65M | 2026-03-31 |
| Eversept Partners, L.P. | Institution | 100,198 | 0.35% | US$ 3.38M | 2026-03-31 |
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