Holding(s) in Company

RNS Number:9167S
Isotron PLC
5 December 2003

                           SCHEDULE 10
 
             NOTIFICATION OF MAJOR INTERESTS IN SHARES


1)   NAME OF COMPANY

     ISOTRON PLC

2)   NAME OF SHAREHOLDER HAVING A MAJOR INTEREST

     FLEMING MERCANTILE INVESTMENT TRUST PLC

3)   Please state whether notification indicates that it is in respect of 
     holding of the Shareholder named in 2 above or in respect of a 
     non-beneficial interest or in the case of an individual holder if it is a
     holding of that person's spouse or children under the age of 18

     2 ABOVE

4)   Name of the registered holder(s) and, if more than one holder, the 
     number of shares held by each of them.

     AS 2 ABOVE

5)   Number of shares/amount of stock acquired.

     225,000

6)   Percentage of issued Class

     1.06%

7)   Number of shares/amount of stock disposed

     -

8)   Percentage of issued Class

     -

9)   Class of security

     25P ORDINARY SHARES

10)  Date of transaction

     NOT KNOWN

11)  Date company informed

     5 DECEMBER 2003

12)  Total holding following this notification

     795,506
               
13)  Total percentage holding of issued class following this notification

     3.77%

14)  Any additional information



15)  Name of contact and telephone number for queries

     MRS C E BRAY
     01793 567900

16)  Name and signature of authorised company official responsible for 
     making this notification

     Date of Notification ..... 5 DECEMBER 2003






                      This information is provided by RNS
            The company news service from the London Stock Exchange
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