- Statement of Changes in Beneficial Ownership (4)

FORM 4 [ X ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES	OMB APPROVAL OMB Number: 3235-0287 Estimated average burden hours per response... 0.5
	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person * MELLO ROBERT A	2. Issuer Name and Ticker or Trading Symbol IRIS INTERNATIONAL INC [ IRIS ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director                      _____ 10% Owner __ X __ Officer (give title below)      _____ Other (specify below) Corp VP/Pres Sample Processing
(Last)          (First)          (Middle) C/O IRIS INTERNATIONAL, INC., 9158 ETON AVENUE	3. Date of Earliest Transaction (MM/DD/YYYY) 10/31/2012
(Street) CHATSWORTH, CA 91311 (City)        (State)        (Zip)	4. If Amendment, Date Original Filed (MM/DD/YYYY)	6. Individual or Joint/Group Filing (Check Applicable Line) _ X _ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	3. Trans. Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	10/31/2012		U		68809	D	$19.50	0	D
Common Stock	10/31/2012		U		100	D	$19.50	0	I	By Son
Common Stock	10/31/2012		M		29167	A	$11.65	29167	D
Common Stock	10/31/2012		M		31416	A	$9.99	60583	D
Common Stock	10/31/2012		M		14177	A	$11.97	74760	D
Common Stock	10/31/2012		M		2529	A	$9.81	77289	D
Common Stock	10/31/2012		M		1689	A	$9.81	78978	D
Common Stock	10/31/2012		F (1)		53283	D	$19.50	25695	D
Common Stock	10/31/2012		S (2)		25695	D	$19.50	0	D

Table II - Derivative Securities Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	4. Trans. Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Stock Option (Right to Buy)	$11.65	10/31/2012		M			29167	(3)	3/4/2013	Common Stock	29167	$0	0	D
Stock Option (Right to Buy)	$9.99	10/31/2012		M			31416	(4)	2/20/2016	Common Stock	31416	$0	4488	D
Stock Option (Right to Buy)	$11.97	10/31/2012		M			14177	(5)	2/23/2017	Common Stock	14177	$0	8507	D
Stock Option (Right to Buy)	$9.81	10/31/2012		M			2529	(6)	2/24/2018	Common Stock	2529	$0	4217	D
Stock Option (Right to Buy)	$9.81	10/31/2012		M			1689	(6)	2/24/2018	Common Stock	1689	$0	2815	D
Stock Option (Right to Buy)	$9.99	10/31/2012		D			4488	(7)	2/20/2016	Common Stock	4488	$9.51	0	D
Stock Option (Right to Buy)	$11.97	10/31/2012		D			8507	(7)	2/23/2017	Common Stock	8507	$7.53	0	D
Stock Option (Right to Buy)	$9.81	10/31/2012		D			4217	(7)	2/24/2018	Common Stock	4217	$9.69	0	D
Stock Option (Right to Buy)	$9.81	10/31/2012		D			2815	(7)	2/24/2018	Common Stock	2815	$9.69	0	D
Performance Restricted Stock Units	(8)	10/31/2012		A		6400		(9)	(9)	Common Stock	6400	$0	6400	D
Performance Restricted Stock Units	(8)	10/31/2012		D			6400	(9)	(9)	Common Stock	6400	$19.50	0	D
Restricted Stock Units	(8)	10/31/2012		D			1254	(10)	(10)	Common Stock	1254	$19.50	0	D
Restricted Stock Units	(8)	10/31/2012		D			2813	(10)	(10)	Common Stock	2813	$19.50	0	D
Restricted Stock Units	(8)	10/31/2012		D			6400	(10)	(10)	Common Stock	6400	$19.50	0	D

Explanation of Responses:
( 1)	The shares were retained by the company in payment of the exercise price and/or withholding taxes incurred in connection with the exercise of options.
( 2)	Pursuant to a Tender and Support Agreement dated September 17, 2012 by and among each director and officer of IRIS International, Inc., IRIS International, Inc., Danaher Corporation and Daphne Acquisition Corporation, the reporting person sold these shares of Common Stock to Daphne Acquisition Corporation in exchange for consideration of $19.50 per share.
( 3)	Vested 25% on March 4, 2009, and thereafter 6.25% vested in 12 equal quarterly installments with the first such installment vesting on June 30, 2009.
( 4)	Vested 25% on February 20, 2010, and thereafter 6.25% will vest / vested in 12 equal quarterly installments with the first such installment vesting on June 30, 2010.
( 5)	Vested 25% on February 23, 2011, and thereafter 6.25% will vest / vested in 12 equal quarterly installments with the first such installment vesting on June 30, 2011.
( 6)	Vested 25% on February 24, 2012, and thereafter 6.25% will vest / vested in 12 equal quarterly installments with the first such installment vesting on June 30, 2012.
( 7)	Pursuant to the Agreement and Plan of Merger dated September 17, 2012 by and among Danaher Corporation, Daphne Acquisition Corporation and IRIS International, Inc. (the "Merger Agreement"), this option vested in full and was cancelled in the merger in exchange for a cash amount equal to the number of shares underlying this option multiplied by the difference between the per share merger consideration of $19.50 and the per share exercise price of this option.
( 8)	Each restricted stock unit represents a contingent right to receive one share of IRIS International, Inc. common stock.
( 9)	Pursuant to the Merger Agreement, these performance restricted stock units, which were granted on February 27, 2012 and were subject to performance-based and time-based vesting, vested in full at the target level of performance and were cancelled in the merger in exchange for a cash amount equal to the number of shares underlying the performance restricted stock units multiplied by the per share merger consideration of $19.50.
( 10)	Pursuant to the Merger Agreement, these restricted stock units vested in full and were cancelled in the merger in exchange for a cash amount equal to the number of shares underlying the restricted stock units multiplied by the per share merger consideration of $19.50.

Reporting Owners
Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
MELLO ROBERT A C/O IRIS INTERNATIONAL, INC. 9158 ETON AVENUE CHATSWORTH, CA 91311			Corp VP/Pres Sample Processing

Signatures
/s/ Todd M. Graham, Attorney-in-Fact		11/1/2012
** Signature of Reporting Person		Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
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