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IONS Ionis Pharmaceuticals Inc

42.23
0.26 (0.62%)
Last Updated: 16:47:23
Delayed by 15 minutes
Share Name Share Symbol Market Type
Ionis Pharmaceuticals Inc NASDAQ:IONS NASDAQ Common Stock
  Price Change % Change Share Price Bid Price Offer Price High Price Low Price Open Price Shares Traded Last Trade
  0.26 0.62% 42.23 42.22 42.24 42.49 41.655 41.87 145,328 16:47:23

Annual Statement of Changes in Beneficial Ownership (5)

14/02/2022 11:41pm

Edgar (US Regulatory)


FORM 5
[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
[ ] Form 3 Holdings Reported
[ ] Form 4 Transactions Reported UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

ANNUAL STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

                                                                                  
OMB APPROVAL
OMB Number: 3235-0362
Estimated average burden
hours per response...
1.0                       
Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

KLEIN JOSEPH III
2. Issuer Name and Ticker or Trading Symbol

IONIS PHARMACEUTICALS INC [IONS]
5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

__X__ Director                    _____ 10% Owner
_____ Officer (give title below)    _____ Other (specify below)
(Last)          (First)          (Middle)

2855 GAZELLE COURT
3. Statement for Issuer's Fiscal Year Ended (MM/DD/YYYY)
12/31/2021 
(Street)

CARLSBAD, CA 92010
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed(MM/DD/YYYY)
 
6. Individual or Joint/Group Filing(Check Applicable Line)

_X_ Form Filed by One Reporting Person
___ Form Filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Trans. Date2A. Deemed Execution Date, if any3. Trans. Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Amount(A) or (D)Price
Common Stock 11/30/2021  G (1)6000 (1)D$0.0 12126 D  
Common Stock 11/30/2021  G (1)6000 (1)A$0.0 6000 I by Trust 
Common Stock        100 I by Son (2)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security3. Trans. Date3A. Deemed Execution Date, if any4. Trans. Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
6. Date Exercisable and Expiration Date
(MM/DD/YYYY)
7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned at End of Issuer's Fiscal Year
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Non-Qualified Stock Option (right to buy) $24.42 11/30/2021  G (3)  12000 (3) 7/1/2017 6/30/2026 Common Stock 12000 $0.0 0 D  
Non-Qualified Stock Option (right to buy) $42.88 11/30/2021  G (3)  12000 (3) 7/2/2019 (4)7/1/2028 Common Stock 12000 $0.0 4000 D  
Non-Qualified Stock Option (right to buy) $52.22 11/30/2021  G (3)  16000 (3) 7/3/2018 7/2/2027 Common Stock 16000 $0.0 0 D  
Non-Qualified Stock Option (right to buy) $57.16 11/30/2021  G (3)  16000 (3) 7/1/2016 6/30/2025 Common Stock 16000 $0.0 0 D  
Non-Qualified Stock Option (right to buy) $60.2 11/30/2021  G (3)  12000 (3) 7/1/2021 6/30/2030 Common Stock 12000 $0.0 0 D  
Non-Qualified Stock Option (right to buy) $64.8 11/30/2021  G (3)  8000 (3) 7/1/2020 (5)6/30/2029 Common Stock 8000 $0.0 8000 D  
Non-Qualified Stock Option (right to buy) $24.42 11/30/2021  G (3)12000 (3)   7/1/2017 6/30/2026 Common Stock 12000 $0.0 12000 I by Trust 
Non-Qualified Stock Option (right to buy) $42.88 11/30/2021  G (3)12000 (3)   7/2/2019 7/1/2028 Common Stock 12000 $0.0 12000 I by Trust 
Non-Qualified Stock Option (right to buy) $52.22 11/30/2021  G (3)16000 (3)   7/3/2018 7/2/2027 Common Stock 16000 $0.0 16000 I by Trust 
Non-Qualified Stock Option (right to buy) $57.16 11/30/2021  G (3)16000 (3)   7/1/2016 6/30/2025 Common Stock 16000 $0.0 16000 I by Trust 
Non-Qualified Stock Option (right to buy) $60.2 11/30/2021  G (3)12000 (3)   7/1/2021 6/30/2030 Common Stock 12000 $0.0 12000 I by Trust 
Non-Qualified Stock Option (right to buy) $64.8 11/30/2021  G (3)8000 (3)   7/1/2020 6/30/2029 Common Stock 8000 $0.0 8000 I by Trust 

Explanation of Responses:
(1) The reported transaction reflects the gift of shares to trusts for the benefit of the reporting person's three children, of which the reporting person's wife is a trustee.
(2) The reporting person disclaims beneficial ownership of all securities held by his son, and this report should not be deemed an admission that the reporting person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose.
(3) The reported transactions reflect the gift of vested stock options to trusts for the benefit of the reporting person's three children, of which the reporting person's wife is a trustee.
(4) Grant of 7/2/18 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. The option vests and becomes exercisable in four equal annual installments, with the first installment vesting on 7/2/19. The option shall be fully vested and exercisable on 7/2/22. The option was exercisable as to 12,000 shares on 11/30/21.
(5) Grant of 7/1/19 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. The option vests and becomes exercisable in four equal annual installments, with the first installment vesting on 7/1/20. The option shall be fully vested and exercisable on 7/1/23. The option was exercisable as to 8,000 shares on 11/30/21.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director10% OwnerOfficerOther
KLEIN JOSEPH III
2855 GAZELLE COURT
CARLSBAD, CA 92010
X



Signatures
By: Patrick R. O'Neil, attorney-in-fact For: Joseph Klein III2/9/2022
**Signature of Reporting PersonDate

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