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| Holder | Type | Held (Actual) | % of Outstanding | Market Value | Date Reported |
|---|---|---|---|---|---|
| FMR LLC | Institution | 16,936,250 | 8.25% | US$ 678.97M | 2026-03-31 |
| Deep Track Capital, LP | Institution | 11,526,971 | 5.61% | US$ 462.12M | 2026-03-31 |
| Deep Track Biotechnology Master Fund, Ltd | Institution | 9,500,000 | 4.63% | US$ 380.86M | 2025-03-19 |
| BlackRock, Inc. | Institution | 6,574,497 | 3.20% | US$ 263.57M | 2026-03-31 |
| Baker Bros. Advisors LP | Institution | 5,457,881 | 2.66% | US$ 218.81M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 4,537,929 | 2.21% | US$ 181.93M | 2026-03-31 |
| TCG Crossover Management, LLC | Institution | 4,457,988 | 2.17% | US$ 178.72M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 3,952,467 | 1.93% | US$ 158.45M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 3,704,905 | 1.80% | US$ 148.53M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 3,620,050 | 1.76% | US$ 145.13M | 2026-03-31 |
| Armistice Capital LLC | Institution | 3,564,916 | 1.74% | US$ 142.92M | 2026-03-31 |
| Two Seas Capital LP | Institution | 3,201,962 | 1.56% | US$ 128.37M | 2026-03-31 |
| Jennison Associates LLC | Institution | 3,196,705 | 1.56% | US$ 128.16M | 2026-03-31 |
| RTW Investments, LP | Institution | 3,177,849 | 1.55% | US$ 127.40M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 2,679,010 | 1.30% | US$ 107.40M | 2026-03-31 |
| Alpine Global Management, LLC | Institution | 2,636,925 | 1.28% | US$ 105.71M | 2026-03-31 |
| Morgan Stanley Investment Management Inc. | Institution | 2,617,956 | 1.28% | US$ 104.95M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 2,092,102 | 1.02% | US$ 83.87M | 2026-03-31 |
| Woodline Partners LP | Institution | 1,975,869 | 0.96% | US$ 79.21M | 2026-03-31 |
| Perceptive Advisors LLC | Institution | 1,597,383 | 0.78% | US$ 64.04M | 2026-03-31 |
| Farallon Capital Management, L.L.C. | Institution | 1,546,000 | 0.75% | US$ 61.98M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 1,188,924 | 0.58% | US$ 47.66M | 2026-03-31 |
| Aberdeen Group Plc | Institution | 1,160,762 | 0.57% | US$ 46.53M | 2026-03-31 |
| Logos Global Management, L.P. | Institution | 1,075,000 | 0.52% | US$ 43.10M | 2026-03-31 |
| Morgan Stanley | Institution | 985,941 | 0.48% | US$ 39.53M | 2026-03-31 |
| UBS Asset Management AG | Institution | 826,279 | 0.40% | US$ 33.13M | 2026-03-31 |
| Bank of America Corporation | Institution | 798,683 | 0.39% | US$ 32.02M | 2026-03-31 |
| StemPoint Capital LP | Institution | 746,494 | 0.36% | US$ 29.93M | 2026-03-31 |
| Candriam, Société En Commandite Par Actions | Institution | 680,372 | 0.33% | US$ 27.28M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 672,774 | 0.33% | US$ 26.97M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 660,438 | 0.32% | US$ 26.48M | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 617,807 | 0.30% | US$ 24.77M | 2026-03-31 |
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