Statement of Changes in Beneficial Ownership (4)

FORM 4

[X] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person * Enamait Drew	2. Issuer Name and Ticker or Trading Symbol CHIASMA, INC [ CHMA ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director                    _____ 10% Owner __X__ Officer (give title below)    _____ Other (specify below) VP, Fin & Admin, PAO
(Last)          (First)          (Middle) C/O CHIASMA, INC., 140 KENDRICK STREET BUILDING C EAST	3. Date of Earliest Transaction (MM/DD/YYYY) 8/5/2021
(Street) NEEDHAM, MA 02494 (City)        (State)        (Zip)	4. If Amendment, Date Original Filed (MM/DD/YYYY)	6. Individual or Joint/Group Filing (Check Applicable Line) _X _ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	3. Trans. Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	4. Trans. Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Stock Option (Right to Buy)	$22.40	8/5/2021		D (1)(2)			16700	(2)	(2)	Common Stock	16700	$0.00	0	D
Stock Option (Right to Buy)	$2.60	8/5/2021		D (1)(2)			65000	(2)	(2)	Common Stock	65000	$0.00	0	D
Stock Option (Right to Buy)	$1.52	8/5/2021		D (1)(2)			11843	(2)	(2)	Common Stock	11843	$0.00	0	D
Stock Option (Right to Buy)	$1.52	8/5/2021		D (1)(2)			33807	(2)	(2)	Common Stock	33807	$0.00	0	D
Stock Option (Right to Buy)	$3.75	8/5/2021		D (1)(2)			32000	(2)	(2)	Common Stock	32000	$0.00	0	D
Stock Option (Right to Buy)	$4.57	8/5/2021		D (1)(2)			55000	(2)	(2)	Common Stock	55000	$0.00	0	D
Stock Option (Right to Buy)	$4.55	8/5/2021		D (1)(2)			85000	(2)	(2)	Common Stock	85000	$0.00	0	D

Explanation of Responses:
(1)	This Form 4 reports securities disposed of pursuant to the terms of the Agreement and Plan of Merger (the "Merger Agreement") dated as of May 4, 2021, by and among Chiasma, Inc. (the "Company), Amryt Pharma plc ("Parent"), and Acorn Merger Sub, Inc., an indirect wholly-owned subsidiary of Parent ("Merger Sub") pursuant to which Merger Sub merged with and into the Company (the "Merger") with the Company surviving as an indirect wholly owned subsidiary of Parent effective as of August [5], 2021 (the "Effective Time").
(2)	At the Effective Time, each option to purchase Shares (each, a "Company Option") that was outstanding and unexercised, immediately prior to the Effective Time, whether or not vested shall, by virtue of the Merger Agreement, ceased to represent a right to acquire Shares, was assumed by Parent and automatically converted into the option to purchase Parent ADSs (each an "Assumed Stock Option") shall be equal to (i) the number of Shares subject to each Company Option immediately prior to the Effective Time multiplied by (ii) the Exchange Ratio, rounded down, if necessary, to the nearest whole number of Parent ADSs, and such Assumed Stock Option shall have an exercise price per Parent ADS (rounded up to the nearest cent) equal to (a) the exercise price per Share otherwise purchasable pursuant to such Company Option divided by (b) the Exchange Ratio.

Reporting Owners
Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Enamait Drew C/O CHIASMA, INC. 140 KENDRICK STREET BUILDING C EAST NEEDHAM, MA 02494			VP, Fin & Admin, PAO

Signatures
/s/ Lee G. Giguere, Attorney-in-Fact		8/5/2021
**Signature of Reporting Person		Date