Initial Statement of Beneficial Ownership (3)

FORM 3	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES	OMB APPROVAL OMB Number: 3235-0104 Estimated average burden hours per response... 0.5
	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person * VESSEY RUPERT	2. Date of Event Requiring Statement (MM/DD/YYYY) 6/15/2016	3. Issuer Name and Ticker or Trading Symbol CELGENE CORP /DE/ [CELG]
(Last)        (First)        (Middle) C/O CELGENE CORPORATION, 86 MORRIS AVENUE	4. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director                            _____ 10% Owner ___ X ___ Officer (give title below)          _____ Other (specify below) See remarks /
(Street) SUMMIT, NJ 07901        (City)              (State)              (Zip)	5. If Amendment, Date Original Filed (MM/DD/YYYY)	6. Individual or Joint/Group Filing (Check Applicable Line) _ X _ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock	3650	D
Common Stock	135	I	401(k) Plan

Table II - Derivative Securities Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security (Instr. 4)	2. Date Exercisable and Expiration Date (MM/DD/YYYY)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Stock Option (right to buy)	(1) (2)	2/2/2025	Common Stock	19142	$118.57	D
Stock Option (right to buy)	(1) (3)	5/4/2025	Common Stock	3125	$109.90	D
Stock Option (right to buy)	(1) (4)	7/27/2025	Common Stock	3125	$132.56	D
Stock Option (right to buy)	(1) (5)	11/9/2025	Common Stock	3125	$114.08	D
Stock Option (right to buy)	(1) (6)	2/1/2026	Common Stock	3125	$100.80	D
Stock Option (right to buy)	(1) (7)	5/2/2026	Common Stock	12906	$104.97	D
Restricted Stock Unit	(8)	(8)	Common Stock	11246	(9) (10)	D
Restricted Stock Unit	(11)	(11)	Common Stock	781	(9) (10)	D
Restricted Stock Unit	(12)	(12)	Common Stock	5350	(9) (10)	D
Restricted Stock Unit	(13)	(13)	Common Stock	6731	(9) (10)	D

Explanation of Responses:
( 1)	The option was issued pursuant to the Company's 2008 Stock Incentive Plan (as amended and restated as of April 15, 2015).
( 2)	The option is immediately exercisable and will vest in four equal annual installments commencing on February 2, 2016.
( 3)	The option is immediately exercisable and will vest in four equal annual installments commencing on May 4, 2016.
( 4)	The option is immediately exercisable and will vest in four equal annual installments commencing on July 27, 2016.
( 5)	The option is immediately exercisable and will vest in four equal annual installments commencing on November 9, 2016.
( 6)	The option is immediately exercisable and will vest in four equal annual installments commencing on February 1, 2017.
( 7)	The option is immediately exercisable and will vest in four equal annual installments commencing on May 2, 2017.
( 8)	The restricted stock units will vest in two annual installments as follows: 5,622 shares on February 2, 2017; 5,623 shares on February 2, 2018. Vested shares will be delivered to the reporting person promptly after the vesting date.
( 9)	The restricted stock unit was issued pursuant to the Company's 2008 Stock Incentive Plan (as amended and restated as of April 15, 2015).
( 10)	Each restricted stock unit represents a contingent right to receive one share of the Company's common stock.
( 11)	The restricted stock units vest on May 4, 2018. Vested shares will be delivered to the reporting person on the vesting date.
( 12)	The restricted stock units vest on December 16, 2018. Vested shares will be delivered to the reporting person on the vesting date.
( 13)	The restricted stock units vest on May 2, 2019. Vested shares will be delivered to the reporting person on the vesting date.

Remarks: President, Research and Early Development

Reporting Owners
Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
VESSEY RUPERT C/O CELGENE CORPORATION 86 MORRIS AVENUE SUMMIT, NJ 07901			See remarks

Signatures
/s/ Rupert Vessey _________________________________________ Rupert Vessey		6/23/2016
** Signature of Reporting Person		Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*	If the form is filed by more than one reporting person, see Instruction 5(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
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