Initial Statement of Beneficial Ownership (3)

FORM 3	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES	OMB APPROVAL OMB Number: 3235-0104 Estimated average burden hours per response... 0.5
	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person * Matthews Andrea	2. Date of Event Requiring Statement (MM/DD/YYYY) 4/17/2023	3. Issuer Name and Ticker or Trading Symbol Astria Therapeutics, Inc. [ATXS]
(Last)        (First)        (Middle) C/O ASTRIA THERAPEUTICS, INC., 75 STATE STREET, SUITE 1400	4. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director                          _____ 10% Owner ___X___ Officer (give title below)        _____ Other (specify below) Chief Business Officer /
(Street) BOSTON, MA 02109       (City)              (State)              (Zip)	5. If Amendment, Date Original Filed(MM/DD/YYYY)	6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security (Instr. 4)	2. Date Exercisable and Expiration Date (MM/DD/YYYY)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Stock Option (Right to Buy)	(1)	8/26/2024	Common Stock	389	$432.00	D
Stock Option (Right to Buy)	(1)	3/25/2025	Common Stock	51	$663.00	D
Stock Option (Right to Buy)	(1)	2/10/2026	Common Stock	166	$274.20	D
Stock Option (Right to Buy)	(1)	9/7/2026	Common Stock	250	$258.60	D
Stock Option (Right to Buy)	(1)	2/8/2027	Common Stock	183	$74.40	D
Stock Option (Right to Buy)	(1)	7/26/2027	Common Stock	83	$76.20	D
Stock Option (Right to Buy)	(1)	2/7/2028	Common Stock	416	$76.80	D
Stock Option (Right to Buy)	(1)	9/6/2028	Common Stock	833	$42.60	D
Stock Option (Right to Buy)	(1)	2/12/2029	Common Stock	2083	$26.34	D
Stock Option (Right to Buy)	(2)	2/11/2030	Common Stock	3333	$31.92	D
Stock Option (Right to Buy)	(3)	10/6/2030	Common Stock	4166	$39.78	D
Stock Option (Right to Buy)	(4)	3/31/2031	Common Stock	66666	$17.22	D
Stock Option (Right to Buy)	(5)	2/28/2032	Common Stock	32812	$6.51	D
Stock Option (Right to Buy)	(6)	1/31/2033	Common Stock	60000	$13.36	D

Explanation of Responses:
(1)	Fully vested.
(2)	This option was granted February 12, 2020 and is subject to vesting over a four-year period, with 25% of the 3,033 shares underlying the option upon grant vesting on the first anniversary of February 12, 2020 and the remainder vesting over the ensuing three years in equal monthly installments.
(3)	This option was granted October 7, 2020 and is subject to vesting over a four-year period, with 25% of the 4,166 shares underlying the option upon grant vesting on the first anniversary of October 7, 2020 and the remainder vesting over the ensuing three years in equal monthly installments.
(4)	This option was granted April 1, 2021 and is subject to vesting over a four-year period, with 25% of the 66,666 shares underlying the option upon grant vesting on the first anniversary of April 1, 2021 and the remainder vesting over the ensuing three years in equal monthly installments.
(5)	This option was granted March 1, 2022 and is subject to vesting over a four-year period, with 25% of the 45,000 shares underlying the option upon grant vesting on the first anniversary of February 17, 2022 and the remainder vesting over the ensuing three years in equal monthly installments.
(6)	This option was granted February 1, 2023 and is subject to vesting over a four-year period, with 25% of the 60,000 shares underlying the option upon grant vesting on the first anniversary of February 1, 2023 and the remainder vesting over the ensuing three years in equal monthly installments.

Remarks: Exhibit Index: 24 - Power of Attorney; No securities are beneficially owned.

Reporting Owners
Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Matthews Andrea C/O ASTRIA THERAPEUTICS, INC. 75 STATE STREET, SUITE 1400 BOSTON, MA 02109			Chief Business Officer

Signatures
/s/ Ben Harshbarger, as attorney-in-fact for Andrea Matthews		4/19/2023
**Signature of Reporting Person		Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*	If the form is filed by more than one reporting person, see Instruction 5(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note:	File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
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