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Share Name | Share Symbol | Market | Type |
---|---|---|---|
Calithera Biosciences Inc | NASDAQ:CALA | NASDAQ | Common Stock |
Price Change | % Change | Share Price | Bid Price | Offer Price | High Price | Low Price | Open Price | Shares Traded | Last Trade | |
---|---|---|---|---|---|---|---|---|---|---|
0.00 | 0.00% | 0.20 | 0.16 | 0.35 | 0 | 01:00:00 |
“In the quarter, Calithera advanced each of our internally discovered first-in-class, small molecule onco-metabolism clinical candidates. We initiated two new phase 2 trials with our oral glutaminase inhibitor and we recently initiated dosing of our oral arginase inhibitor in combination with a checkpoint inhibitor,” said Susan Molineaux, PhD, President and Chief Executive Officer of Calithera. “Our clinical development plans are progressing and we plan to present clinical updates on CB-839, including the initial results of CB-839 dosed in combination with Bristol Myers Squibb’s Opdivo® (nivolumab) at the Annual Meeting of the Society for Immunotherapy of Cancer (SITC).”
Third Quarter 2017 and Recent Highlights
CB-839
INCB01158
Corporate
Selected Third Quarter 2017 Financial Results
Cash, cash equivalents and investments totaled $196.5 million at September 30, 2017.
Revenue was $7.3 million for the three months ended September 30, 2017 and represents the portion of deferred revenue recognized in the third quarter from the company’s collaboration and license agreement with Incyte.
Research and development expenses were $10.8 million for the three months ended September 30, 2017, compared with $6.3 million for the same period in the prior year. The increase of $4.5 million was due to an increase in the CB-839 program to support our new and ongoing clinical trials, including the company’s two Phase 2 trials which began in the third quarter of 2017, as well as investment in our early stage research programs, offset by decreases in the INCB01158 program, primarily due to Incyte’s co-funding of development costs.
General and administrative expenses were $3.1 million for the three months ended September 30, 2017, compared with $2.3 million for the same period in the prior year. The increase of $0.8 million was due to increases in professional services and higher personnel-related costs.
Net loss from operations for the three months ended September 30, 2017 was $6.1 million, or $0.17 per share.
Conference Call Information
Calithera will webcast a clinical update on CB-839 on Saturday, November 11th at 3:30 p.m. Pacific Time/ 6:30 p.m. Eastern Time. The call can be accessed by dialing (855) 783-2599 (domestic) or (631) 485-4877 (international), and referring to conference ID 1878409. To access the live audio webcast or the subsequent archived recording, visit the Investors section of the Calithera website at www.calithera.com. The webcast will be recorded and available for replay on Calithera’s website for 30 days.
About Calithera
Calithera Biosciences, Inc. is a clinical-stage pharmaceutical company focused on discovering and developing novel small molecule drugs directed against tumor metabolism and tumor immunology targets for the treatment of cancer. Calithera’s lead product candidate, CB-839, is a potent, selective, reversible and orally bioavailable inhibitor of glutaminase. CB-839 takes advantage of the pronounced dependency many cancers have on the nutrient glutamine for growth and survival. It is currently being evaluated in Phase 2 clinical trials in combination with standard of care agents. INCB01158 is a first-in-class immuno-oncology metabolic checkpoint inhibitor targeting arginase, a critical immunosuppressive enzyme responsible for T-cell suppression by myeloid-derived suppressor cells. Arginase depletes arginine, a nutrient that is critical for the activation, growth and survival of the body’s cancer-fighting immune cells, known as cytotoxic T-cells. INCB01158 is being developed in collaboration with Incyte Corporation and is currently in a Phase 1 clinical trial. Calithera is headquartered in South San Francisco, California. For more information about Calithera, please visit www.calithera.com.
Forward Looking Statements
Statements contained in this press release regarding matters that are not historical facts are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as "may," "will," "expect," "anticipate," "estimate," "intend," "poised" and similar expressions (as well as other words or expressions referencing future events, conditions, or circumstances) are intended to identify forward-looking statements. These statements include those related to the timing of Calithera’s clinical trials, Calithera’s ability to fund its clinical programs, and Calithera’s receipt of clinical data from its clinical trials. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. The potential product candidates that Calithera develops may not progress through clinical development or receive required regulatory approvals within expected timelines or at all. In addition, clinical trials may not confirm any safety, potency or other product characteristics described or assumed in this press release. Such product candidates may not be beneficial to patients or successfully commercialized. The failure to meet expectations with respect to any of the foregoing matters may have a negative effect on Calithera's stock price. Additional information concerning these and other risk factors affecting Calithera's business can be found in Calithera's periodic filings with the Securities and Exchange Commission at www.sec.gov. These forward-looking statements are not guarantees of future performance and speak only as of the date hereof, and, except as required by law, Calithera disclaims any obligation to update these forward-looking statements to reflect future events or circumstances.
Calithera Biosciences, Inc. | |||||||||||||||
Selected Consolidated Statements of Operations Financial Data | |||||||||||||||
(in thousands, except per share amounts) | |||||||||||||||
(unaudited) | |||||||||||||||
Three Months Ended September 30, | Nine Months Ended September 30, | ||||||||||||||
2017 | 2016 | 2017 | 2016 | ||||||||||||
Revenue: | |||||||||||||||
Collaboration revenue | $ | 7,254 | $ | — | $ | 18,701 | $ | — | |||||||
Total revenue | 7,254 | — | 18,701 | — | |||||||||||
Operating expenses: | |||||||||||||||
Research and development | 10,833 | 6,313 | 27,615 | 21,155 | |||||||||||
General and administrative | 3,074 | 2,319 | 9,230 | 7,575 | |||||||||||
Total operating expenses | 13,907 | 8,632 | 36,845 | 28,730 | |||||||||||
Loss from operations | (6,653 | ) | (8,632 | ) | (18,144 | ) | (28,730 | ) | |||||||
Interest income, net | 582 | 88 | 1,292 | 246 | |||||||||||
Net loss | $ | (6,071 | ) | $ | (8,544 | ) | $ | (16,852 | ) | $ | (28,484 | ) | |||
Net loss per share, basic and diluted | $ | (0.17 | ) | $ | (0.44 | ) | $ | (0.53 | ) | $ | (1.50 | ) | |||
Weighted average common shares used to compute net loss per share, basic and diluted | 35,475 | 19,507 | 32,072 | 18,963 | |||||||||||
Calithera Biosciences, Inc. | ||||||||
Selected Consolidated Balance Sheet Financial Data | ||||||||
(in thousands) | ||||||||
(unaudited) | ||||||||
September 30, | December 31, | |||||||
2017 | 2016 | |||||||
Balance Sheet Data: | ||||||||
Cash, cash equivalents and investments | $ | 196,533 | $ | 51,781 | ||||
Working capital | 134,630 | 49,108 | ||||||
Total assets | 205,543 | 54,796 | ||||||
Deferred revenue | 38,299 | — | ||||||
Total liabilities | 47,451 | 4,890 | ||||||
Accumulated deficit | (139,358 | ) | (122,502 | ) | ||||
Total stockholders’ equity | 158,092 | 49,906 | ||||||
Contact:Jennifer McNealeyir@Calithera.com650-870-1071
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