Notification Filed by a National Securities Exchange to Report the Removal From Listing and Registration of Matured , Redeemed or Retired Securities (25)

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 25

NOTIFICATION OF REMOVAL FROM LISTING AND/OR

REGISTRATION UNDER SECTION 12(b) OF THE

SECURITIES EXCHANGE ACT OF 1934

Commission File Number 001-37418

Sio Gene Therapies Inc.

The Nasdaq Stock Market LLC

(Exact name of Issuer as specified in its charter, and name of Exchange where security is listed and/or registered)

1501 Broadway

12th Floor

New York, New York 10036

Tel: [phone]

(Address, including zip code, and telephone number, including area code, of Issuer’s principal executive offices))

Common Stock, par value $0.00001 per share

(Description of class of securities)

Please place an X in the box to designate the rule provision relied upon to strike the class of securities from listing and registration:

¨			17 CFR 240.12d2-2(a)(1)

¨			17 CFR 240.12d2-2(a)(2)

¨			17 CFR 240.12d2-2(a)(3)

¨			17 CFR 240.12d2-2(a)(4)

¨			Pursuant to 17 CFR 240.12d2-2(b), the Exchange has complied with its rules to strike the class of securities from listing and/or withdraw registration on the Exchange.

ý			Pursuant to 17 CFR 240.12d2-2(c), the Issuer has complied with the rules of the Exchange and the requirements of 17 CFR 240.12d2-2(c) governing the voluntary withdrawal of the class of securities from listing and registration on the Exchange.

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SIGNATURE

    Pursuant to the requirements of the Securities Exchange Act of 1934, Sio Gene Therapies Inc. certifies that it has reasonable grounds to believe that it meets all of the requirements for filing the Form 25 and has caused this notification to be signed on its behalf by the undersigned duly authorized person.

SIO GENE THERAPIES INC.

Dated:

April 6, 2023

By:

/s/ David Nassif

Name:

David Nassif

Title:

Chief Executive Officer; Chief Financial Officer; Chief Accounting Officer; and General Counsel