Initial Statement of Beneficial Ownership (3)

FORM 3	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES	OMB APPROVAL OMB Number: 3235-0104 Estimated average burden hours per response... 0.5
	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person * Manning Paul B	2. Date of Event Requiring Statement (MM/DD/YYYY) 2/10/2016	3. Issuer Name and Ticker or Trading Symbol AveXis, Inc. [AVXS]
(Last)        (First)        (Middle) C/O AVEXIS, INC., 2275 HALF DAY ROAD, SUITE 160	4. Relationship of Reporting Person(s) to Issuer (Check all applicable) __ X __ Director                            ___ X ___ 10% Owner _____ Officer (give title below)          _____ Other (specify below)
(Street) BANNOCKBURN, IL 60015        (City)              (State)              (Zip)	5. If Amendment, Date Original Filed (MM/DD/YYYY)	6. Individual or Joint/Group Filing (Check Applicable Line) ___ Form filed by One Reporting Person _ X _ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock	219177	D   (1)
Common Stock	24352	I	By LLC   (2)

Table II - Derivative Securities Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security (Instr. 4)	2. Date Exercisable and Expiration Date (MM/DD/YYYY)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Class B-1 Common Stock	(3)	(3)	Common Stock	8469	(3)	D   (1)
Class B-1 Common Stock	(3)	(3)	Common Stock	941	(3)	I	By LLC   (2)
Class B-1 Common Stock	(3)	(3)	Common Stock	1659237	(3)	I	By LLC   (4)
Warrants to purchase Class B-2 Common Stock (Right to Buy)	(5)	3/7/2024	Class B-2 Common Stock   (3)	130623	$2.57	I	By LLC   (6)
Warrants to purchase Class B-2 Common Stock (Right to Buy)	(5)	5/4/2025	Class B-2 Common Stock   (3)	137154	$2.57	I	By LLC   (6)

Explanation of Responses:
( 1)	These shares are held by Mr. Manning together with his spouse as Joint Tenants with Right of Survivorship.
( 2)	These shares are held by BKB Growth Investments, LLC ("BKB"). Mr. Manning is a co-manager of BKB and, as such, has unilateral voting and investment power with respect to the shares held by BKB. Mr. Manning disclaims beneficial ownership of the shares held by BKB except to the extent of his pecuniary interest therein, and the inclusion of the securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 or for any other purpose.
( 3)	The Class B-1 Common Stock and the Class B-2 Common Stock will automatically convert into the same number of shares of Common Stock upon the closing of the Issuer's initial public offering. The Class B-1 Common Stock and the Class B-2 Common Stock have no expiration date.
( 4)	These shares are held by PBM Capital Investments, LLC ("PBM"). Mr. Manning has the sole voting and investment power with respect to the shares held by the PBM. Mr. Manning disclaims beneficial ownership of the shares held by PBM except to the extent of his pecuniary interest therein, and the inclusion of the securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 or for any other purpose.
( 5)	Immediately exercisable.
( 6)	These Warrants are held by PBM. Mr. Manning has the sole voting and investment power with respect to the shares held by PBM. Mr. Manning disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein, and the inclusion of the securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 or for any other purpose.

Remarks: Exhibit List - Exhibit 24 - Power of Attorney

Reporting Owners
Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Manning Paul B C/O AVEXIS, INC. 2275 HALF DAY ROAD, SUITE 160 BANNOCKBURN, IL 60015	X	X
PBM Capital Investments, LLC C/O AVEXIS, INC. 2275 HALF DAY ROAD, SUITE 160 BANNOCKBURN, IL 60015		X

Signatures
/s/Madison Jones, Attorney-in-Fact		2/10/2016
** Signature of Reporting Person		Date
Madison Jones, Attorney-in-Fact		2/10/2016
** Signature of Reporting Person		Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*	If the form is filed by more than one reporting person, see Instruction 5(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note:	File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
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