Statement of Changes in Beneficial Ownership (4)

FORM 4

[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person * Topper James N	2. Issuer Name and Ticker or Trading Symbol ANAPTYSBIO, INC [ ANAB ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director                    _____ 10% Owner _____ Officer (give title below)    _____ Other (specify below)
(Last)          (First)          (Middle) C/O FRAZIER HEALTHCARE PARTNERS, 601 UNION STREET, SUITE 3200	3. Date of Earliest Transaction (MM/DD/YYYY) 11/16/2020
(Street) SEATTLE, WA 98101 (City)        (State)        (Zip)	4. If Amendment, Date Original Filed (MM/DD/YYYY)	6. Individual or Joint/Group Filing (Check Applicable Line) _X _ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	3. Trans. Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	11/16/2020		J(1)		973612	D	$0.00	0	I	By: Frazier Healthcare V, L.P. (2)
Common Stock	11/16/2020		J(3)		344860	D	$0.00	700171	I	By: Frazier Healthcare VII, L.P. (4)
Common Stock	11/16/2020		J(5)		98275	D	$0.00	199529	I	By: Frazier Healthcare VII-A, L.P. (6)
Common Stock	11/16/2020		J(7)		22604	A	$0.00	54458	D
Common Stock	11/16/2020		J(8)		26354	A	$0.00	80812 (9)	D

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	4. Trans. Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:
(1)	Represents a pro rata distribution in-kind by Frazier Healthcare V, L.P. to its limited partners for no consideration.
(2)	The reportable securities were held directly by Frazier Healthcare V, L.P. FHM V, L.P. is the general partner of Frazier Healthcare V, L.P. FHM V, L.L.C. is the general partner of FHM V, L.P. James Topper is one of five managing members of FHM V, L.L.C. Dr. Topper disclaims beneficial ownership of the securities held by Frazier Healthcare V, L.P., except to the extent of his pecuniary interest therein, if any.
(3)	Represents a pro rata distribution in-kind by Frazier Healthcare VII, L.P. to its limited partners for no consideration.
(4)	The reportable securities are held directly by Frazier Healthcare VII, L.P. FHM VII, L.P. is the general partner of Frazier Healthcare VII, L.P. FHM VII, L.L.C. is the general partner of FHM VII, L.P. James Topper is one of six managing members of FHM VII, L.L.C. Dr. Topper disclaims beneficial ownership of the securities held by Frazier Healthcare VII, L.P., except to the extent of his pecuniary interest therein, if any.
(5)	Represents a pro rata distribution in-kind by Frazier Healthcare VII-A, L.P. to its limited partners for no consideration.
(6)	The reportable securities are held directly by Frazier Healthcare VII-A, L.P. FHM VII, L.P. is the general partner of Frazier Healthcare VII-A, L.P. FHM VII, L.L.C. is the general partner of FHM VII, L.P. James Topper is one of six managing members of FHM VII, L.L.C. Dr. Topper disclaims beneficial ownership of the securities held by Frazier Healthcare VII-A, L.P., except to the extent of his pecuniary interest therein, if any.
(7)	Shares acquired by Dr. Topper through a distribution in-kind from Frazier Healthcare V, L.P.
(8)	Shares acquired by Dr. Topper through a distribution in-kind from Frazier Healthcare VII, L.P.
(9)	Dr. Topper also holds stock options to purchase up to an aggregate of 38,000 shares of the Issuer's Common Stock, which stock options vest according to their terms, in addition to the 80,812 shares of Common Stock that are held directly by Dr. Topper.

Reporting Owners
Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Topper James N C/O FRAZIER HEALTHCARE PARTNERS 601 UNION STREET, SUITE 3200 SEATTLE, WA 98101	X

Signatures
/s/ Steve R. Bailey, Attorney-In-Fact for James N. Topper		11/18/2020
**Signature of Reporting Person		Date