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IDM and Cambridge Laboratories Sign an Exclusive Marketing
Agreement for Junovan(TM) (Mepact) in the United Kingdom and Ireland
PARIS, June 21 /PRNewswire-FirstCall/ -- IDM (Immuno-Designed Molecules), a
privately held biopharmaceutical company, the shareholders of which recently
entered into an agreement to combine with Epimmune Inc. (NASDAQ: EPMN), today
announced that it has signed an exclusive marketing agreement for Junovan
(Mepact or L-MTP-PE) in the United Kingdom and Ireland with Cambridge
Laboratories Ltd, a privately owned British pharmaceutical company. Junovan,
known as Mepact throughout clinical development, is the brand name the product
will be marketed under worldwide, upon obtaining necessary regulatory
approvals.
In exchange, IDM will receive an upfront license fee and milestone payments
throughout the development of the product prior to launch, as well as royalties
calculated on product sales.
Junovan is an immune system stimulator designed to destroy cancer cells by
activating macrophages present in the patient. Results from a phase III,
randomized clinical trial demonstrated that in 664 patients suffering from
non-metastatic osteosarcoma that was amenable to resection, Junovan, given with
chemotherapy compared to chemotherapy alone, significantly extended survival
without relapse as well as overall survival. Severe adverse events were those
typically associated with high dose chemotherapy and surgery. Adverse events
associated with Junovan are related to its biologic activity and generally
include mild to moderate fever, chills, rigors, fatigue, nausea and increases
in serum proteins associated with macrophage activation. The clinical trial was
conducted in the United States by the Children's Oncology Group, in children
with newly diagnosed high grade osteosarcoma, and the results were presented at
the American Society of Pediatric Hematology/Oncology (ASPHO) Annual Meeting in
May 2005.
Junovan was granted orphan drug status for the treatment of osteosarcoma in the
U.S. in 2001 and in Europe in 2004. Junovan is currently limited to clinical
investigational use only; its safety and efficacy have not been reviewed or
approved for commercial distribution by any regulatory agency. IDM plans to
file a marketing application with regulatory authorities in the U.S. and Europe
in the first half of 2006.
Jean Loup Romet-Lemonne, Chairman and Chief Executive of IDM said, "Cambridge
is an excellent partner for IDM, given their focus on the development and
commercialization of innovative medicines. They have a dynamic sales and
marketing team that we are confident will maximize the potential for Junovan in
the UK and Ireland."
Mark Evans, Chief Executive of Cambridge laboratories commented, "Junovan is a
significant addition to our exciting pipeline of new medicines and we are
delighted to have made this deal with IDM. The clinical results are very
encouraging, in light of the fact that no new agent has been available in the
treatment of osteosarcoma over the last 20 years."
Osteosarcoma is the most common form of pediatric bone tumor. Approximately 900
new cases are diagnosed each year in the United States, with a similar number
in Europe.
For further information please contact
Press contact IDM : Euro RSCG C&0 :
Nadine Sciacca, Directeur Marie-Carole de Groc/Florence
Communication Macaire
Tel.: +33-(0)-1-40-09-04-11 +33-(0)1-58-47-95-07/+33-(0)1-58
E-mail: 47-95-18
Press contact Cambridge : FourGritti Healthcare :
Mark Evans, Chief Executive Joanna Marchant/ Martin Sutton
Office Tel:
Tel: +44-191-296-9370 +44-7747-610310 or +44-7884-495293
About IDM
To date, approximately 98% of IDM's shareholders have entered into a definitive
agreement to combine IDM with Nasdaq publicly traded Epimmune Inc. in an
all-stock transaction expected to close in the third quarter of 2005. Epimmune
has filed a proxy statement with the United States Securities and Exchange
Commission in connection with the transaction, which is subject to approval by
the Epimmune stockholders and certain other closing conditions.
IDM is a biopharmaceutical company focused on the development of innovative
products to treat and control cancer while maintaining the patient's quality of
life. IDM is currently developing two lines of products: one aiming at the
destruction of residual cancer cells after the use of traditional therapies,
and the other to prevent tumor recurrence by triggering an immune response.
IDM's most advanced product has completed a Phase III clinical trial, five
other products are in clinical trials and five are in preclinical development.
For more information, visit http://www.idm-biotech.com/.
About Cambridge Laboratories Ltd
Cambridge Laboratories is a successful, privately owned pharmaceutical company
which focuses on the development and commercialisation of innovative medicines,
with particular emphasis on the central nervous system, oncology and specialist
therapy areas. Through effective in-licensing and acquisition it has
established a strong portfolio of products as well as an exciting pipeline of
new medicines. The Company has a dynamic sales and marketing organisation,
which operates via a unique international network of distribution partnerships
helping patients throughout the world
Where You Can Find Additional Information About IDM's Proposed Combination with
Epimmune
Epimmune Inc. has filed a preliminary proxy statement concerning its proposed
combination with IDM with the Securities and Exchange Commission (SEC).
Investors and security holders are advised to read the proxy statement related
to the proposed transaction because it contains important information related
to the transaction. Investors and security holders may obtain a free copy of
the proxy statement and other documents filed by Epimmune with the SEC at the
SEC's website at http://www.sec.gov/. The proxy statement and any other
documents filed by Epimmune with the SEC may also be obtained free of charge
from Epimmune by directing such request to Epimmune's Secretary at the
following address: 5820 Nancy Ridge Drive, San Diego, California 92121.
Information Concerning Participation in Epimmune's Proxy Solicitation
IDM and Epimmune and their respective executive officers and directors may be
deemed to be participants in the solicitation of proxies from the stockholders
of Epimmune with respect to the proposed transaction between Epimmune and IDM.
Information regarding Epimmune's executive officers and directors is included
in Epimmune's Annual Report on Form 10-K filed with the SEC for the year ended
December 31, 2004. This document is available free of charge at the SEC's
website at http://www.sec.gov/ and from Epimmune at http://www.epimmune.com/.
Investors and security holders may obtain additional information about the
interests of the respective executive officers and directors of Epimmune and
IDM in the proposed transaction between Epimmune and IDM by reviewing the proxy
statement related to the transaction filed with the SEC.
DATASOURCE: IDM (Immuno-Designed Molecules)
CONTACT: For further information please contact Press contact IDM :
Nadine Sciacca, Directeur Communication, Tel.:
+33-(0)-1-40-09-04-11, E-mail: ; Press
contact Cambridge: Mark Evans, Chief Executive Officer, Tel:
+44-191-296-9370; Euro RSCG C&0 : Marie-Carole de Groc/Florence
Macaire, +33-(0)1-58-47-95-07/+33-(0)1-58-47-95-18,
, ;
FourGritti Healthcare: Joanna Marchant/ Martin Sutton, Tel:
+44-77-47-610310 or +44-7884-495293