ONI BioPharma to Commence Trading on the Over-the-Counter Bulletin Board on Monday, December 22, 2008; ONI BioPharma to Post ...

  
    
  
  
    
      Oragenics, Inc. d/b/a ONI Biopharma Inc. (the "Company" or "ONI" 
      AMEX:ONI), an American biopharmaceutical company that has developed 
      broad-based technologies in oral care, antibiotics, diagnostics and 
      weight control, today announced that commencing Monday, December 22, 
      2008, quotations for the Company's shares will be available on the 
      Over-the-Counter (OTC) Bulletin Board. To the extent a change in the 
      Company's trading symbol occurs the Company expects to issue a press 
      release announcing the new symbol. The transition to the OTC is expected 
      to be seamless to investors. Investors should be able to trade their ONI 
      shares through their brokers in the same manner as they had been prior 
      to this date.
    
    
      Stanley B. Stein, Chief Executive Officer of ONI BioPharma commented, 
      “We are thrilled to be trading in two markets, the OTC and Alternext 
      Paris, that are best suited to biotechnology and healthcare companies. 
      We consider ourselves to be a global company and therefore benefit 
      greatly by having both a domestic and international trading presence. 
      Our facilities are headquartered in the US but our outreach is 
      worldwide. We invite you to listen to our audio release, available at 
      our website www.onibiopharma.com, 
      which will explain this in more detail and will be posted in English and 
      in French.”
    
    
      The OTC Bulletin Board is a quotation service that displays real-time 
      quotes, last-sale prices and volume information in over-the-counter 
      securities. The Financial Industry Regulatory Authority (FINRA), a 
      self-regulatory organization of the securities industry in the United 
      States, oversees the OTC Bulletin Board. In a separate press release 
      issued on December 11, 2008, ONI BioPharma announced that ONI's shares 
      will also be traded on Alternext Paris. The new OTC Bulletin Board 
      listing will have no impact on the status of ONI's Alternext Paris 
      listing, which occurred on December 15, 2008.
    
    
      The Company also announced that later today, it will post on its website 
      (www.onibiopharma.com) 
      the English version of an audio release from management that will answer 
      frequently-asked investor questions on the Company’s strategic plan and 
      the trading of its shares. The Company expects to post the French 
      version of the release on its website on December 23, 2008.
    
    
      About ONI BioPharma
    
    
      Oragenics, Inc. (d/b/a ONI BioPharma Inc.) is a biopharmaceutical 
      company with a pipeline of unique proprietary technologies, some of 
      which are being commercialized. The Company also has a number of 
      products in discovery, preclinical and clinical development, with a 
      concentration in the main therapeutic area of infectious diseases, 
      diagnostics, and oral health. The Company has developed platform 
      technologies with respect to its products, thereby creating a potential 
      pipeline of future products, which the Company expects to develop.
    
    
      Forward-looking Statements
    
    
      Safe Harbor Statement Under the Private Securities Litigation Reform Act 
      of 1995: This press release includes forward-looking statements that 
      reflect ONI BioPharma’s current views with respect to future events and 
      financial performance. These forward-looking statements are based on 
      management’s beliefs and assumptions and information currently 
      available. The words “believe,” “expect,” “anticipate,” “intend,” 
      “estimate,” “project” and similar expressions that do not relate solely 
      to historical matters identify forward-looking statements. Investors 
      should be cautious in relying on forward-looking statements because they 
      are subject to a variety of risks, uncertainties, and other factors that 
      could cause actual results to differ materially from those expressed in 
      any such forward-looking statements. ONI expressly disclaims any 
      responsibility to update forward-looking statements and draws the 
      attention of investors to the risk factors described in the Information 
      Document.
    
    
      This press release does not constitute the offering of any securities 
      for sale. The Company's securities may not be offered or sold absent 
      registration under applicable securities laws or an exemption from 
      registration. Any public offering of the securities of the Company will 
      be made by means of a prospectus that will contain detailed information 
      about the offering and the Company.