Navidea Signs Deal to Sublicense NAV4694 Worldwide Development Rights

Navidea Biopharmaceuticals (NYSE MKT:NAVB) (“Navidea” or “the Company”), a company focused on the development of precision immunodiagnostic agents and immunotherapeutics, today announced it has signed a deal to provide Meilleur Technologies, Inc.,(Meilleur) a wholly owned subsidiary of Cerveau Technologies, Inc. (Cerveau), worldwide rights to conduct research using NAV4694, a beta-amyloid imaging agent being evaluated as an aid in the differential diagnosis of early-onset Alzheimer’s disease, as well as an exclusive license for the development and commercialization of NAV4694 in Australia, Canada, China, and Singapore. Meilleur also has an option to commercialize worldwide. Meilleur and Cerveau are focused on enhancing access to key technologies to advance and improve brain health.

As a result of the agreement, the litigation initiated by Beijing Sinotau Medical Research Co., Ltd. (Sinotau), a subsidiary of Hainan Sinotau Pharmaceutical Co., Ltd., will be dismissed.

About NAV4694

NAV4694 is a Fluorine-18 labeled precision radiopharmaceutical candidate intended for use in Positron Emission Tomography (PET) imaging and evaluation of patients with signs or symptoms of cognitive impairment such as Alzheimer’s disease (AD). NAV4694 binds to beta-amyloid deposits in the brain that can then be imaged in scans. Beta-amyloid plaque pathology is widely used in the diagnosis of AD. The ability of NAV4694 imaging to display amyloid plaque pathology may enable earlier identification of AD and improve monitoring of disease progression and interpretation of brain scan images. There is an ongoing NAV4694 Phase 2b trial in Mild Cognitive Impairment and a Phase 3 program for NAV4694 in AD.

About Meilleur Technologies, Inc. and Cerveau Technologies, Inc.

Meilleur Technologies, Inc., is a wholly owned subsidiary of Cerveau Technologies, Inc. Cerveau is a partnership between Enigma Biomedical Group, Inc. and Sinotau Pharmaceutical Group. Cerveau's vision is to globally develop diagnostics and technology that will impact patients with neurodegenerative disorders including Alzheimer's disease. Cerveau Technologies, has recently announced an agreement to develop a novel Tau tracer with pharmaceutical partners in which the utilization of amyloid imaging biomarkers can be complementary to the overall management of Neurodegenerative disease.

About Navidea

Navidea Biopharmaceuticals, Inc. (NYSE MKT: NAVB) is a biopharmaceutical company focused on the development of precision immunodiagnostic agents and immunotherapeutics. Navidea is developing multiple precision-targeted products based on its Manocept™ platform to enhance patient care by identifying the sites and pathways of disease and enable better diagnostic accuracy, clinical decision-making, and targeted treatment. Navidea’s Manocept platform is predicated on the ability to specifically target the CD206 mannose receptor expressed on activated macrophages. The Manocept platform serves as the molecular backbone of Tc 99m tilmanocept, the first product developed and commercialized by Navidea based on the platform. The development activities of the Manocept immunotherapeutic platform are being conducted by Navidea in conjunction with its subsidiary, Macrophage Therapeutics, Inc. Navidea’s strategy is to deliver superior growth and shareholder return by bringing to market novel products and advancing the Company’s pipeline through global partnering and commercialization efforts. For more information, please visit www.navidea.com.

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Navidea Biopharmaceuticals, Inc.Jed Latkin, 614-551-3416CFO/[e-mail] AdvisorsTirth Patel, [e-mail]