Share Name Share Symbol Market Type Share ISIN Share Description
Verseon Corporation LSE:VERS London Ordinary Share COM USD0.001 (DI)
  Price Change % Change Share Price Bid Price Offer Price High Price Low Price Open Price Shares Traded Last Trade
  +0.00p +0.00% 42.00p 40.00p 44.00p 42.00p 42.00p 42.00p 0 08:00:00
Industry Sector Turnover (m) Profit (m) EPS - Basic PE Ratio Market Cap (m)
Pharmaceuticals & Biotechnology 0.0 -16.9 -11.0 - 67.00

Verseon Corporation Verseon presents DME candidate at ARVO 2019

30/04/2019 7:02am

RNS Non-Regulatory


TIDMVERS

Verseon Corporation

30 April 2019

Press release

April 30, 2019

Verseon Corporation

("Verseon" or the "Company")

Verseon presents oral drug candidate for diabetic eye disease that could replace eye injections

Fremont, Calif.-Verseon presented promising preclinical data for their first diabetic eye disease development candidate for clinical trials at this week's ARVO 2019 annual meeting in Vancouver. This new drug candidate for oral dosing could lead to the first real alternative to eye injections, the current standard of care for millions of diabetics at risk of losing their eye sight.

Diabetic macular edema (DME) is a leading cause of adult blindness, affecting about one in three long-term diabetes patients. With the prevalence of diabetes on the rise around the globe, preventing complications like DME is becoming increasingly urgent. However, the current standards of care for DME are regular injections into the eye-treatments that are associated with side effects including inflammation and infection and that work poorly or not at all in about half of patients. Recent studies have also shown that 25% of patients fail to follow up with their eye injections, leaving them at risk of eventual vision loss.

Verseon's new development candidate, which is aimed for oral administration, has the potential to fill a large unmet need for both treatment and prevention of DME.

At ARVO 2019, Dr. Melissa Calton, Verseon's Program Manager of Ophthalmology, presented preclinical data for the Company's lead development candidate for clinical trials from their new class of small-molecule plasma kallikrein inhibitors. In preclinical models, the compound showed good efficacy against two important drivers of the disease-the kallikrein and VEGF pathways-following administration of a single oral dose.

"What's most exciting about our DME candidates isn't just that they may replace eye injections, but that they could give doctors an opportunity to prevent diabetes patients from developing DME in the first place," said Dr. Calton. "Its excellent pharmacokinetic profile sets our development candidate apart from other candidates, making it suitable for administration as a pill. We are very encouraged by our preclinical results and are working to bring this candidate into clinical trials."

About Verseon's diabetic macular edema program

Verseon has developed a new class of potent, selective small-molecule plasma kallikrein inhibitors for the treatment of diabetic macular edema (DME), a major cause of adult blindness. In contrast to current customary DME treatments that are administered as recurring eye injections, Verseon develops drug candidates for oral dosing. Several lead candidates have demonstrated efficacy in reducing retinal thickening and retinal leakage, two hallmarks of the disease, when administered orally. The Company is currently preparing a first DME development candidate for phase 1 trials.

About Verseon

Verseon Corporation (www.verseon.com, AIM:VERS) is developing disruptive life-science technology to advance global health. The clinical-stage company is using its proprietary, computational drug discovery platform to discover new drug candidates that are unlikely to be found using conventional methods. Pairing its computational platform with a comprehensive in-house chemistry and biology workflow, the company has built a growing pipeline of drug programs. Verseon currently has four active drug programs in the areas of anticoagulation (currently in phase 1), diabetic macular edema, hereditary angioedema, and oncology.

Find Verseon on Twitter and LinkedIn.

-Ends-

For further information, please contact

 
 Verseon Corporation                        www.verseon.com 
 Sebastian Wykeham / Tina Schlafly          +1 (510) 225 9000 
 
 Arden Partners (NOMAD and Joint Broker) 
 Ruari McGirr / Ciaran Walsh / Alex         +44 (0) 20 7614 
  Penney                                     5900 
 
 Cantor Fitzgerald Europe (Joint Broker) 
                                            +44 (0) 20 7894 
 Phil Davies                                 7000 
 

For financial and business media enquiries, please contact

 
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 Henry Harrison-Topham / Jamie Hooper          5000 
 

For trade and pharma media enquiries, please contact

 
 Vane Percy & Roberts 
                         +44 (0) 1737 821 
 Simon Vane Percy         890 
 

This information is provided by RNS, the news service of the London Stock Exchange. RNS is approved by the Financial Conduct Authority to act as a Primary Information Provider in the United Kingdom. Terms and conditions relating to the use and distribution of this information may apply. For further information, please contact rns@lseg.com or visit www.rns.com.

END

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April 30, 2019 02:02 ET (06:02 GMT)

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