Tiziana Life Sciences Share Discussion Threads

[mach100] 27/4/2016 20:20

Possibly profit taking to take advantage or lock in positions during its breather. Of course we might get Midiclib news Thursday or Friday which could send this rocketing or crashing!

[jpuff] 27/4/2016 11:22

I'm holding firm

[impala391] 27/4/2016 11:10

Tree shake

[wageslave] 27/4/2016 11:00

Wave of panic selling. Any ideas?

[runwaypaul] 22/4/2016 11:52

nice action gla.

[mach100] 20/4/2016 12:42

Midiclib news can't be too far away. This had almost halved so although it has to date had a good recovery we are some way off highs. The CLN's from January's fundraising are cashable at £1.50 s0 120p to 135p was a bargain for pi's. When this moves it moves in bounds- of course this applies to down as well as up.

[andrbea] 20/4/2016 09:30

so why the rise (13%)?

[jpuff] 15/4/2016 10:17

I raised the price buying just under 500 shares ! Seems very illiquid so could move fast on good news? Hoping and GLA all

[runwaypaul] 15/4/2016 09:51

blimey only bought 1000 shares and it kicked it up 7%! gla

[impala391] 14/4/2016 11:22

Yes it would be good to get some news. Been reading a blog of a patient on the trial. She started in Jan 16 .
They have 3weeks on the drug and three weeks off. After the first lot her cancer stopped growing. Her latest update was beginning of April 16. Her second 6 week cycle had ended and she was told her cancer was stabilised , not growing, which was good news. They are carrying on with the treatment. She says not every one has had success with this but a significant number are successes.
It looks like the trial is ongoing. I am not going to post the site as I don't want lots of people bombarding her with questions. DYOR .

[mach100] 13/4/2016 15:37

"The miliciclib trials have been extended to April 2016." Wonder how long it will take to assess the information and get some news out? If the news is good this one should fly.

[impala391] 15/3/2016 13:38

What we need is good news similar to GWP trial results . They have been in a similar position to us , now look at it. Come on Tils how about some news on Milciclib !

[mach100] 10/3/2016 12:25

Strong intraday rebound this morning which leads me to believe that sellers have had their day on this (in the absence of bad news of course). When this moves, it moves in bounds.

[impala391] 10/3/2016 09:01

Found this on phase 11 trial whilst trawling the net.

Results: To date, 43 pts have been treated (male/female 18/25; median age 55, range 21-80, TC/B3T 26/9). The second stage of the trial is ongoing and 599 cycles have been administered with a median number of 7 cycles/pts. Out of 30 pts whose data are available and mature, 14 are successes (PFS-3 rate = 46.7%; 95%CI 28.3-65.7%) including a RECIST 1.1 PR. Toxicity was generally moderate. The most common Grade 3-4 AE are nausea and asthenia (8.3%), vomiting, myasthenic syndrome, dehydration, hypophosphatemia, cytolytic hepatitis, plantar fascitis (4.2%). The most common Grade 3-4 hematological and biochemical toxicities are neutropenia (8.4%), creatinine, amylase and lipase increase (5.6%). Conclusions: The study has already met its predefined primary endpoint in treated patients and therefore we thought it was useful to report these data in a rare disease although the per protocol analysis is to be done on evaluable patients. This supports its full investigation as potential new therapeutic agent to treat TC/B3T. Clinical trial information: NCT01011439.
This was from 2014.
And it was a success then so they carried on treating patients and now are in preclinical with liver cancer. Draw your own conclusions.

hxxp://meetinglibrary.asco.org/content/131226-144

[impala391] 01/3/2016 09:35

Yes Mach100 I have been researching Milciclib, the one in phase two trials and back in 2009 it said they found it to be very effective in melanoma cell sample experiments, and they have started preclinical trials in liver cancer in Jan2016 so it begs the question why start trials in liver cancer so it must be pretty good.
I think the drop occurred because we were all expecting some more news on CB1 to start trials instead they said they intended to apply for phase 1 trials during 2016. As always with bio techs time scales do get varied.
We should get some news on the phaseII trial but also another phaseII trial running along side should finish in June with results in August, hence the warrants and CLN converting in September 2016. So every thing should be hunky dory. IMO
Everything I have said is out there so I am confident things will progress but as always DYOR.

[mach100] 29/2/2016 17:12

Anyone know what is behind the drop? Seems completely overblown to me, There are warrants at 220p and a recent placing at 150p so I am confident that this will grow. Being watching for a while and very happy with my entry point. I hope the phase II trial in March is a success so this one can recover lost ground.

[impala391] 25/2/2016 08:44

Preclinical trials of Milciclib for liver cancer started in January 2016
hxxp://adisinsight.springer.com/drugs/800026196
And phase 11 trial expected data March 2016
hxxps://clinicaltrials.gov/ct2/show/record/NCT01301391

[stav5001] 24/2/2016 10:14

Is anyone out there?

[stav5001] 27/1/2016 18:04

Asmodeus

Still not sure of what happened here, my broker account says I have 4166 in TILS as a result of my previous disastrous holding of 1.25M in REGEN

[rovi70] 03/1/2016 23:36

MMM! RGT not a rebirth?

[asmodeus] 03/1/2016 11:24

02 Jan 2016
Company Website changed:
Was: Unknown
Now:

(I seem to remember there is some connection?)