Synairgen Share Discussion Threads

[saw89] 24/3/2020 09:54

SNG001 was identified in the WHO's Landscape analysis of therapeutics as at 17 February 2020 as the only Phase 2/Phase 3/Observational therapy delivered by the inhaled rout

[tidy 2] 24/3/2020 09:51

Impressive so the beauty of SNG001 is that it is not just COVID19 that it has a use for it can likely be used for all viral effected lung diseases besides its current P2 trials for COPD Asthma influenza etc etc? So if COVID19 mutates again SNG001 will likely be effective for this also once it is proven?

[nobbygnome] 24/3/2020 09:50

Of course the nature of the antibody response depends on your genes and will be different in all of us. So that's part of the reason why you can't say everybody will be immune but the vast majority will be.

[nobbygnome] 24/3/2020 09:49

The vast majority will. My understanding is that although it can mutate it's not like the flu virus which changes dramatically so most people will remain immune.

[oby_1] 24/3/2020 09:48

As part of European trial which includes remdesivir they are going to use interferon beta in one arm of the trial. Does anyone know how this is administered? IV?If it is IV then given the general consensus that this route can be ineffective and problematic at best would it not have been better to use an inhaled version?

[saw89] 24/3/2020 09:48

Also what people are missing is this helps prevent lasting damage to lungs from covid -19

[flavio_monteiro] 24/3/2020 09:47

Nobby, will people who get Covid19 and recover be definitely immune from getting it again?

[hazl] 24/3/2020 09:47

yes good informed posts imo

[nobbygnome] 24/3/2020 09:46

If the trial result is positive, the pressure to approve it straight away will be immense. They won't have to do another trial IMHO. There will be post marketing commitments but essentially the drug will be used in what is essentially a phase IV post marketing trial.

[iamgreat1] 24/3/2020 09:46

Someone desperately dumping

[tidy 2] 24/3/2020 09:46

So if COVID19 mutates to yet another strain and you have antibodies already from the previous strain then you stand a better chance of survival. The trick is to keep your patients alive in order for the antibodies to be created initially and that's where SNG001 comes in?

[saw89] 24/3/2020 09:44

If this immediately helps patients in critical conditions then you think they will wait ?? Of course they won’t.

[nobbygnome] 24/3/2020 09:42

People will still be catching this disease next year. That is the issue with the lock down. You flatten the curve now but extend the period when the virus will be around for much longer. Ultimately most of us will catch it but it will be over a few years. The problem is the crisis in ICUs not that people are infected. Over a long period the latter cannot be avoided.

[tidy 2] 24/3/2020 09:41

Toff the effects of the drug are apparent short term as Nobby has posted but the antibodies to the virus are produced by the body over a longer term. Therefore the drug keeps the patient alive in order for the antibodies to be created. You know when the patient is kept alive by the drugs effects that the drug is effective in doing its job. So improvements will be shown as the drug takes effect short term and therefore proves itself to be effective.

[74tom] 24/3/2020 09:39

Also if SNG are too late then the same applies to FARN and every other treatment or drug that is currently being expedited! Sadly this isn’t true or we wouldn’t be at the start of an interminable worldwide lockdown...

[nobbygnome] 24/3/2020 09:39

Yes. It is pointless testing for antibodies to determine if someone is infected before or as you get symptoms. This sort of test is only useful after the event to determine who really was infected with Covid 19. For example with health workers who self isolate because they had some symptoms but weren't tested. Once they have recovered the antibody test, if positive would prove they had Covid 19, are now immune and can go back to work treating patients with little or no risk of catching the disease again or indeed infecting patients.

[hsdeo1] 24/3/2020 09:37

Toffeeman sowing seeds of doubt!

[74tom] 24/3/2020 09:36

@Toffeeman,

“Potentially too late for the many not the few”

Care to explain how you came to this bizarre conclusion?

[tidy 2] 24/3/2020 09:35

Thanks Nobby very good. So they can see the results of the drug in short term and if they keep the patient for later testing they can identify antibodies for the disease as they develop in the body?

[nobbygnome] 24/3/2020 09:33

I wonder if Link had a few more shares to offload. Must be just about finished by now.

The point about the day of the RNS is a good one. That was completely mad price action but was linked to Link offloading. However, of course it turned out to be a very good opportunity. Late on last Wednesday I bought an extra 20k at 25p, which is looking like an exceedingly good purchase now. At the time I was a bit bemused by what was going on but stuck with my convictions. I think the same applies now...

[toffeeman] 24/3/2020 09:32

100 patients - 2 months to measure effectiveness - tiny wrt to the number of people who will be critical.

Potentially too late for the many not the few

[likya123] 24/3/2020 09:32

Seller clearing...up we go!

[saw89] 24/3/2020 09:30

NHS is desperate to take the load off ventilators and that’s why this is being deployed to 100 patients . Shocked it’s still the cheap. Great for people to get in !

[toffeeman] 24/3/2020 09:29

Nobby - but look at the drop in FARN market cap! about 50% from the peak