Skinbiotherapeutics Share Discussion Threads

[rathean] 06/4/2018 12:13

Up 16% on the day, starting to form a quite steep rising trend... early days but we might see an N4P effect.

[parob] 06/4/2018 11:48

Skinbiotherapeutics PLC Q&A: MTA with Global Consumer Goods Company (LON:SBTX)

Posted by: Amilia Stone 5th April 2018

Skinbiotherapeutics PLC (LON:SBTX) Chief Executive Officer Dr Cath O’Neill caught up with DirectorsTalk for an exclusive interview to discuss the signing of an MTA with a global consumer goods company

Q1: Cath, yesterday you announced a signing of a Materials Transfer Agreement with a global consumer goods company, can you tell us what does the MTA mean?

A1: So, the Materials Transfer Agreement basically means that we, as a company, have agreed to hand over some of our technology to this other company so that they can run it through some tests and work on it themselves, the material refers to the technology. So, that’s basically what it is in a nutshell.

Q2: What does this mean then for Skinbiotherapeutics?

A2: Well, I think what it signals is that the ‘big boys’ in the consumer goods space are sitting up and taking notice of us, it’s not every day that a global giant spends its time testing the technology of a little tiny company like Skinbiotherapeutics. So, I think it’s a test to the quality of our research data, our science and the fact that they are sitting up and taking notice of us now.

[shrewdmole] 06/4/2018 11:16

I've said it before but I believe a commercial tie up will come before human trials as j and j will want to have input into those trials IMHO.

[bobalot] 06/4/2018 11:06

Excellent, The share price has bounced off the lower support and it's heading north again.

[bdog51] 06/4/2018 08:14

Just topped up at 8.9p which is still a bargain here, but the 11% spread is ridiculous and can put off potential buyers. No reason for the MMs to do this other than trying to put the brakes on to stop traders?

[onedayrodders] 05/4/2018 19:54

no Raythean .. not aimed at you just sellers at these depressed prices

[rathean] 05/4/2018 15:42

It'd be nice to see this become a multi-bagger this year but actually the full capital gain will be if and when the terms of the J&J tie-up post trials are published.

[rafboy] 05/4/2018 13:31

Rathean, I am looking for at least a tripling of the current share price when human trials prove successful. That should happen before year end and potentially in Q3. In my view SBTX is cheap at current levels.

[rathean] 05/4/2018 11:06

I hope that wasn't aimed at me Rodders!? I was already a holder and increased this morning still with an 18 month outlook for a five multi-bagger from here assuming human trials don't burn someone's face off...I do my 12 minute day trading elsewhere :)

[rathean] 05/4/2018 10:07

Just topped up, seems rude not to at this price. Potential or establishing an upward trend from here from recent lows... but if not this is an 18 month hold for me.

[bobalot] 04/4/2018 22:00

That research suggests SkinBio have not only discovered a groundbreaking ingredient for cosmetic/ medical creams, gels and lotions the same micobe also inhibits skin cancer.

Making their patents for the microbes a must have ingredient imo worth billions.

[bobalot] 04/4/2018 21:57

Here is the whole story from Cardiff Uni:

A type of bacteria commonly found on human skin produces a substance that may help protect against skin cancer, researchers have revealed.

The scientists say the surprise discovery regarding a strain of Staphylococcus epidermidis highlights the importance of the community microbes found on and in the body in preventing disease.

While it is not clear whether the absence of this strain could increase the risk of skin cancer in individuals, the team say that it is possible the findings might one day lead to preventive treatments for patients.

“The presence of this strain may provide natural protection, or it might be used therapeutically to inhibit the growth of various forms of cancer,” said Prof Richard Gallo, a co-author of the research from the University of California, San Diego.

The finding was somewhat serendipitous. With previous research showing that chemicals produced by Staphylococcus species commonly found on healthy human skin can kill off certain harmful bacteria, the team looked at numerous strains to explore their antimicrobial powers.

Writing in the journal Science Advances, Gallo and colleagues describe how among their results, they discovered a strain of Staphylococcus epidermidis which produced a substance that killed off a type harmful bacteria responsible for infections such as strep throat. While it was not the only strain to do so, the chemical these microbes produced was unusual, boasting a structure similar to one of the key components of DNA, called adenine.

“The strain was originally detected in a screen for antimicrobial activity, but when we identified the nature of the chemical produced by this strain we proceeded with experiments to determine if it might have activity against tumours,” said Gallo.

The researchers found that the chemical, called 6-N-hydroxyaminopurine (6-HAP), hindered the production of DNA, with work in cell cultures revealing that 6-HAP prevents several types of tumour cells from growing and multiplying.

By injecting mice with this substance, the team found that 6-HAP is not toxic. However, when melanoma cells were introduced to mice, animals which had received 6-HAP intravenously ended up with tumours that were more than 60% smaller than those that had not received the substance.

The team also found application of the 6-HAP-producing strain of Staphylococcus epidermidis to the skin of mice appeared to greatly reduce both the number of pre-malignant skin tumours formed when the creatures were exposed to ultraviolet light, and number of mice affected, compared to those exposed to a strain that did not produce the substance.

While Staphylococcus epidermidis is commonly found on human skin, the team say about 20% of the healthy population is likely to have a strain which produces 6-HAP. “Our study found that it is common, but not on everyone,” said Gallo.

Julian Marchesi, professor of human microbiome research at Cardiff University who was not involved in the study, welcomed the findings.

“[This research] further adds to a growing understanding of how important the human microbiota, and in this case the skin microbiome, is to health. We have evolved to need these microbes and desperately need to understand all the roles they play in human biology and start to think more about what it is to be a human being,” he said. “The next stage of this exciting work, will be to translate it to human clinical trials and show that this bacterially produced chemical can protect the host from skin cancers.”

[bobalot] 04/4/2018 21:55

TAKE A READ OF THIS GROUND BREAKING RESEARCH --- Skinbio are at its leading edge with their discoveries for the same microbes:


Common human skin bacteria could protect against cancer, say researchers
Staphylococcus epidermidis may help to protect against skin cancer, and could lead to preventive treatments, scientists reveal

[elrico] 04/4/2018 16:40

  SkinbioticsProfessor Holger Bruggeman from AARHUS University challenged the notion of probiotic and pathogen in his presentation on acne. Propionibacterium acnes (which now changed name to Cutibacterium acnes) can be good or bad depending on its type and on the host. Acne-associated strains induce less IL-10 and more IFN? and IL-17 compared to health-associated strains. On the other hand, S. epidermis can inhibit P. acnes, but ESS-deficient S. epidermis mutant induces an increase in IL-8 production in exposed keratinocytes. This is yet another argument in favour of a functional approach rather than species. In this sense Probiotical is developing probiotics for the management of acne thanks to their immunomodulation properties.Catherine O'Neill from Skin Biotherapeutics harnesses the power of a probiotic lysate for skin health, through three activities: the improvement of skin barrier function, the inhibition of S. aureus, and the promotion of wound healing.More on skinbiotics and on C. acnes to be followed with the Microbiome Congress in Rotterdam offering a dedicated room to talks on the skin microbiome.https://www.linkedin.com/pulse/hot-topics-from-pharmabiotics-conference-2018-paris-nina-vinot

[onedayrodders] 04/4/2018 13:20

and in last nights London Evening Standard

[suzy39again] 04/4/2018 12:46

Small mention in the Daily Mails FTSE yesterday section re its RNS and rise.

[jimmylufc] 04/4/2018 12:12

That's what I call a confident interview ! Thanks Elrico

[bobalot] 04/4/2018 11:32

That video interview was excellent --- she said it was very encouraging that a very large international consumer goods company is showing a lot of interest. And there are plenty of other corporates interested as well.

After successful trials this stock is set to fly imo.

[bobalot] 04/4/2018 11:19

Elrico---good article/ video --- the PR machine is saying it as it is with clarity:

Industry heavyweights 'sitting up and taking notice' of SkinBio's technology
2018-04-04 08:22:00




Dr Cath O'Neill, chief executive of SkinBioTherapeutics PLC (LON:SBTX), tells Proactive they've granted access to their proprietary SkinBiotix technology to a major, global consumer goods company.

Having shared the initial pre-clinical data with a number of interested parties, one potential partner to date has progressed to a material transfer agreement - a standard agreement governing the transfer of material between parties enabling the recipient to assess the technology.

Should the unnamed consumer goods company like what it sees, the arrangement could lead to a commercial arrangement between the two companies.

[elrico] 04/4/2018 10:59

"Industry heavyweights sitting up and taking notice."

YouTube


Proactive

[rathean] 03/4/2018 16:45

Ah bobalot, always entertaining. I don't comment much on this holding, super excited for the future and now J&J tie up just makes this a must own share at these prices. There will be more dips so patient buying through the summer to maximise capital gain starting with commencement of human trials imo.

[belgrano2] 03/4/2018 16:41

I would like a very big pot of it to try out on my wife, she needs it.

[belgrano2] 03/4/2018 16:38

One big positive about the skin product for me is the margins. We have heard that it can beneficially change the texture and elastically of skin. In effect make skin look younger.

This is the Holy Grail of skin cream manufacturers, as lets face it the world is stuffed full of older women who would willingly give their eye teeth and pay dearly
for products that "restores youth" in appearance and touch to their skin.

Using natural bacteria to do this is ground breaking, and if successful and properly publicized by the eventual manufacturers would almost instantly become a market "best seller", attracting very premium prices for a product that would be in continual demand by users.