Shield Therapeutics PLC Investor presentations

TIDMSTX

Shield Therapeutics PLC

23 January 2019

Shield Therapeutics plc

("Shield" or the "Group")

Investor presentations

London, UK, 23 January 2019: Shield Therapeutics plc (LSE:STX), a commercial stage, pharmaceutical company with an initial focus on addressing iron deficiency, announces it will be presenting at two investor presentations this month.

Proactive Investors One2One Investor Forum

Tim Watts, CFO, will be presenting at the Proactive Investors One2One Investor Forum on Thursday 24 January 2019 at the Chesterfield Mayfair Hotel, 35 Charles Street, Mayfair, W1J 5EB, starting from 6.00pm. The event brings together high net worth investors and private investors with an interest in growth stocks.

The Growth & Innovation Forum 2019

Shield will have a stand at the Growth & Innovations Forum 2019, held on Tuesday 29 January at The Business Design Centre, 52 Upper Street, Islington, London, N1 0QH. CFO, Tim Watts will be presenting at 3.30pm in the Babbage Room. This is a one-day investor event exhibiting companies focussed on growth and technology, attracting both institutional and retail investors.

The presentations will be available on the Company website shortly after the events here - https://www.shieldtherapeutics.com/investors/presentations

No new material information will be disclosed at either event.

- Ends -

For further information please contact:

Shield Therapeutics plc [phone]

Carl Sterritt, Chief Executive Officer

Tim Watts, Chief Financial Officer

Financial PR [phone]

Consilium Strategic Communications

Mary-Jane Elliott/Matthew Neal

About Feraccru(R)

Feraccru(R) is a novel, stable, non-salt, oral formulation of ferric iron, which has a differentiated mechanism of absorption compared to salt-based oral iron therapies. When salt-based oral iron therapies are ingested, the iron must dissociate from the salt in the GI tract to allow the iron to be absorbed and treat the IDA. This free iron readily chelates to form insoluble clumps and produces damaging free radicals that together cause a range of mild-to-severe GI adverse events, including nausea, bloating and constipation, leading to poor tolerability, reduced patient compliance and ultimately treatment failure. In addition, many patients with IDA are concurrently treated with medicines that raise the pH in the gut which further reduces the effect of salt-based oral iron therapies as they require highly acidic conditions to be absorbed.

Feraccru(R) is not an iron salt, and iron can be absorbed from the ferric maltol molecule, and as a result, it does not routinely cause the same treatment-limiting intolerance issues. Feraccru(R) has been shown in clinical trials to be well-tolerated by patients even when they had previously failed treatment with salt-based oral iron therapies, which should lead to increased patient compliance and better patient outcomes.

Currently, the only treatment option for IDA patients who cannot tolerate salt-based oral iron therapies, is IV iron therapy. IV iron therapies quickly increase iron stores via direct administration of very large doses of iron, causing an increase in Hb levels that is physiologically controlled and occurs over a period of weeks, as is the case with Feraccru(R). IV iron therapies, however, are invasive, costly, inconvenient and complex to administer, and also come with potentially life-threatening, spontaneous hypersensitivity reactions.

About Shield Therapeutics plc

Shield is a commercial stage, pharmaceutical company delivering innovative specialty pharmaceuticals to address patients' unmet medical needs. Our clear purpose is to help our patients become people again, by enabling them to enjoy the things that make the difference in their everyday lives. The Group has a marketed product, Feraccru(R), for the treatment of iron deficiency in adult patients with or without anaemia. Feraccru(R) has exclusive IP rights until the mid-2030's. For more information please visit www.shieldtherapeutics.com.

Forward-Looking Statements

This press release contains forward-looking statements. All statements contained in this press release that do not relate to matters of historical fact should be considered forward-looking statements. These forward-looking statements are based on management's current expectations and include statements related to the timing of future results of Feraccru trials and the timing and success of the Group's regulatory plans and commercial strategy for Feraccru. These statements are neither promises nor guarantees, but involve known and unknown risks and uncertainties, many of which are beyond our control, that may cause actual results, performance or achievements to be materially different from management's expectations expressed or implied by the forward-looking statements, including, but not limited to, risks associated with the regulatory approval process, the Group's business and results of operations, competition and other market factors. The forward-looking statements made in this press release represent management's expectations as of the date of this press release, and except as required by law, the Group disclaims any obligation to update any forward-looking statements contained in this release, even if subsequent events cause our views to change.

This information is provided by RNS, the news service of the London Stock Exchange. RNS is approved by the Financial Conduct Authority to act as a Primary Information Provider in the United Kingdom. Terms and conditions relating to the use and distribution of this information may apply. For further information, please contact [e-mail] or visit www.rns.com.

END

NRACKNDDKBKDPDB

(END) Dow Jones Newswires

January 23, 2019 05:19 ET (10:19 GMT)