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[ronwilkes123] 22/4/2019 18:56

Excellent pieric

[petewy] 22/4/2019 17:28

Thanks Eric

[rhomboid] 22/4/2019 15:59

Thanks Eric

I’m in top up mode so your PR effort is

a) excellent
b) early

I’m hoping as thread creator you also have editor privileges..

[glasshalfull] 22/4/2019 15:57

Excellent Eric...many thanks 👏🏻👏🏻8079;🏻

Kind regards,
GHF

[pireric] 22/4/2019 15:43

Hi guys;

Thought the header was getting a bit out of date and quite long. Have set up a new thread (link below), but feel free to ignore and keep using this one if preferred. I've added a summary of the financial forecasts, and have added a graphic I've made over the weekend, showing a basic summary of the group today.

Let me know if any suggestions



Eric

[pireric] 22/4/2019 15:42

SDI Group (LSE:SDI) is a designer and manufacturer of niche scientific and high technology products, serving a wide mix of public and private businesses, and also consumers. The group is growing both strongly organically, but also seeks to acquire complementary business lines from the UK private market.

[steptoes yard] 16/4/2019 13:19

No govt wants to do anything about things like that with the inherent state pension liabilities

[glaws2] 16/4/2019 12:38

CJD - mad cow disease for humans

[steptoes yard] 16/4/2019 12:36

wat is cjb?

[ronwilkes123] 16/4/2019 11:15

Just going off last year apologies I didn't know Hastings had a more precise date

[pireric] 16/4/2019 11:10

1st couple of weeks of May was the timeframe that Hastings was suggesting, Ron

[ronwilkes123] 16/4/2019 10:56

Trading update next week hopefully Friday

[buywell2] 16/4/2019 10:24

I'll do better than that


I will stop posting on this thread completely and let you guys have the floor to yourselves

[pireric] 16/4/2019 10:19

Buywell - can you at least consolidate your CJD posts and post 1 a day at most? In any case, copying these articles ad verbatim in bulk from their sites is definitely against their copyright rules/T&Cs.

It's akin to me going onto an oil producing company's board and posting several articles per day on what the oil price is going to do. Quite frankly most posters wouldn't find it very interesting, nor that it adds value to the company discussion.

[buywell2] 16/4/2019 10:15

April 4 2019


Alzheimer's disease probably affects twice as many people as current estimates suggest, experts believe, but sufferers are yet to show symptoms.

Scientists at the Mayo Clinic in Minnesota have been re-evaluating the prevalence of the disease using brain imaging to give a definitive assessment of the numbers affected.

However, tests on 2,500 people found twice as many as expected had the tell-tale signs of protein plaques and tangles in the brain that are the marks of the disease, even though they were not yet experiencing dementia.

Dr Cliff Jack, a professor of Alzheimer's research at the Mayo Clinic, said the prevalence of the condition was at present "based on clinical assessment, 'do you have dementia?'

"But as a general rule the prevalence of amyloid [protein plaques] and tau [tangles] as denoted by bio-markers is about two times higher," he said. "Classically defined Alzheimer's undercounts people who have the pathology but do not have symptoms."




buywell says : the protein plaques and tau tangles are MISFOLDED proteins as defined in my previous proteopathy video link.


Now factor in this


Unfortunately, although autopsies once were performed on approximately half of all corpses, the frequency has dropped to 15 percent or less in the United States. The National Center for Health Statistics -- a branch of the CDC -- stopped collecting autopsy data in 1995.

"If we don't do autopsies and we don't look at people's brains ... we have no idea about what is the general prevalence of these kinds of infections and (whether) it is changing," Manuelidis said.

At the same time autopsies have been declining, the number of deaths attributed to Alzheimer's has increased more than 50-fold since 1979, going from 857 deaths then to nearly 50,000 in 2000. Though it is unlikely the dramatic increase in Alzheimer's is due entirely to misdiagnosed CJD cases, it "could explain some of the increase we've seen," Manuelidis said.

"Neurodegenerative disease and Alzheimer's disease have become a wastebasket" for mental illness in the elderly that is difficult to diagnose conclusively, she said. "In other words, what people call Alzheimer's now is more broad than what people used to call it, and that has the possibility of encompassing more diseases -- including CJD."

The autopsy studies that found undiagnosed CJD cases raise the question of whether the United States "already has an undetected epidemic here," Jeff Nelson, director of vegsource.com, a vegetarian advocacy Web site, told UPI.

[block4gooner] 15/4/2019 17:32

52 week high is 53.50

[ihatemms] 15/4/2019 17:21

Eric - like you I have 1/3 of my holdings in SDI (hold over 0.2% of the company). The others 1/3 are in International Greetings and 1/3 in Future plc - both super companies in their own right which continually under-promise and over-deliver and are delivering superb returns. The connection between the companies - they diversify risk and make very shrewd acquisitions but above all it's top quality MANAGEMENT, MANAGEMENT, MANAGEMENT . As you say- invest in the best and forget the rest (1 bad risky investment wrecks your whole portfolio as I've learnt at great cost over the years).

Hastings quick question for you if you don't mind . Ken and Mike are doing superbly well but how long do you think they well stay at the helm/consider retiring (I have no idea how old they are?)

[gconvery] 15/4/2019 17:13

Is that an all time high close? Seems to be...

[hastings] 15/4/2019 16:26

Interesting to see that Berenberg is now our second largest holder behind BGF, followed by Herald and Octopus.

[buywell3] 15/4/2019 16:21

This is what the CDC say, they and the FDA regarding CWD and CJD are as much use as a chocolate teapot


Reprocessing Surgical Instruments Used on Suspected or Confirmed CJD Patients


Inactivation studies have not rigorously evaluated the effectiveness of actual cleaning and reprocessing methods used in health care facilities. Recommendations to reprocess instruments potentially contaminated with the CJD agent are primarily derived from in vitro inactivation studies that used either brain tissues or tissue homogenates, both of which pose enormous challenges to any sterilization process.

The World Health Organization (WHO) has developed CJD infection control guidelines
that can be a valuable guide to infection control personnel and other health care workers involved in the care of CJD patients.

Destruction of heat-resistant surgical instruments that come in contact with high infectivity tissues, albeit the safest and most unambiguous method as described in the WHO guidelines, may not be practical or cost effective.


One of the three most stringent chemical and autoclave sterilization methods outlined in Annex III of the WHO guidelines (see below) should be used to reprocess heat-resistant instruments that come in contact with high infectivity tissues (brain, spinal cord, and eyes) and low infectivity tissues (cerebrospinal fluid, kidneys, liver, lungs, lymph nodes, spleen, olfactory epithelium, and placenta) of patients with suspected or confirmed CJD. High and low infectivity tissues were defined on the basis of available experimental data as described in Table 2 of the WHO guidelines.

The stringent sterilization methods described below should be used to reprocess medical instruments that come in contact with high infectivity tissues of persons known to be blood relatives of patients with inheritable forms of TSEs.

In addition, instruments should be kept moist and not allowed to air dry throughout the surgical procedure by immersing them in water or disinfectant solution.
Chemical and Autoclave Sterilization Methods Outlined in Annex III of the WHO

Infection Control Guidelines for Transmissible Spongiform Encephalopathies
The three most stringent sterilization methods for heat-resistant instruments described in Annex III of the WHO guidelines are listed below; the methods are listed in order of more to less severe treatments. Sodium hypochlorite may be corrosive to some instruments, such as gold-plated instruments. Before instruments are immersed in sodium hypochlorite, the instrument manufacturer should be consulted about the instrument’s tolerance of exposure to sodium hypochlorite. Instruments should be decontaminated by a combination of the chemical and recommended autoclaving methods before subjecting them to cleaning in a washer cycle and routine sterilization.

Immerse in a pan containing 1N sodium hydroxide (NaOH) and heat in a gravity displacement autoclave at 121°C for 30 min; clean; rinse in water; and subject to routine sterilization.

[CDC NOTE: The pan containing sodium hydroxide should be covered, and care should be taken to avoid sodium hydroxide spills in the autoclave. To avoid autoclave exposure to gaseous sodium hydroxide condensing on the lid of the container, the use of containers with a rim and lid designed for condensation to collect and drip back into the pan is recommended. Persons who use this procedure should be cautious in handling hot sodium hydroxide solution (post-autoclave) and in avoiding potential exposure to gaseous sodium hydroxide, exercise caution during all sterilization steps, and allow the autoclave, instruments, and solutions to cool down before removal.

An experiment Cdc-pdf [PDF – 88KB] conducted by Food and Drug Administration (FDA) investigators indicated that the use of appropriate containment pans and lids prevents escape of sodium hydroxide vapors that may cause damage to the autoclave (Brown and Merritt. Am J Infect Control 2003;31:257-260).]

Immerse in 1N NaOH or sodium hypochlorite (20,000 ppm available chlorine) for 1 hour; transfer instruments to water; heat in a gravity displacement autoclave at 121°C for 1 hour; clean; and subject to routine sterilization.
[CDC NOTE: Sodium hypochlorite may be corrosive to some instruments.]
Immerse in 1N NaOH or sodium hypochlorite (20,000 ppm available chlorine) for 1 hour; remove and rinse in water, and then transfer to open pan and heat in a gravity displacement (121°C) or porous load (134°C) autoclave for 1 hour; clean; and subject to routine sterilization.
[CDC NOTE: Sodium hypochlorite may be corrosive to some instruments.]

FDA investigators evaluated the effects to surgical instruments of the steps involved in the sterilization protocols listed above; some of the protocols they assessed subjected the instruments to harsher conditions than those prescribed above. Their findings indicate that much of the damage from autoclaving in sodium hydroxide was cosmetic and would not affect the performance or cleaning of the instruments. Soaking in sodium hydroxide had the least damaging effect on instruments, but immersion in sodium hypochlorite bleach caused severe damage to some instruments. The article summarizing the findings of this experiment
Cdc-pdf

[PDF – 211KB] by Brown et al. of the FDA was published in the Journal of Biomedical Materials Research (electronic version published October 2004).
Reprocessing Instruments used in Patients with no Clear Diagnosis of CJD at the Time of Their Neurosurgical Procedure

In some patients undergoing neurosurgery, a CJD diagnosis that is not suspected before the procedure may be confirmed after the neurosurgery. For this group of patients, in whom the clinical diagnosis leading to the neurosurgical procedure remains unclear, the instruments should be reprocessed in the same manner as that for instruments used in procedures involving suspected or confirmed CJD patients. Unless a clear non-CJD diagnosis is established, these patients should be considered as potentially suspected CJD patients for all other infection control requirements.

Decontaminating Heat-sensitive Instruments or Materials that come in Contact with Suspected or Confirmed CJD Patients
All disposable instruments, materials, and wastes that come in contact with high infectivity tissues (brain, spinal cord, and eyes) and low infectivity tissues (cerebrospinal fluid, kidneys, liver, lungs, lymph nodes, spleen, and placenta) of suspected or confirmed TSE patients should be disposed of by incineration. Surfaces and heat-sensitive re-usable instruments that come in contact with high infectivity and low infectivity tissues should be decontaminated by flooding with or soaking in 2N NaOH or undiluted sodium hypochlorite for 1 hour and rinsed with water.
[CDC NOTE: Sodium hypochlorite may be corrosive to some instruments.]
Precautions for Embalming the Bodies of Patients with Suspected or Confirmed CJD
An autopsied or traumatized body of a suspected or confirmed CJD patient can be embalmed, using the precautions outlined in the WHO CJD infection control guidelines
External

. CJD patients who have not been autopsied or whose bodies have not been traumatized can be embalmed using Standard Precautions. Family members of CJD patients should be advised to avoid superficial contact (such as touching or kissing the patient’s face) with the body of a CJD patient who has been autopsied. However, if the patient has not been autopsied, such contact need not be discouraged.



The WHO in 2003 also did a gloss over of the problem

[buywell3] 15/4/2019 16:04

What do you care you sold out of sdi ages ago to put it into OIL stocks like HUR and SIA

Get back to your greasy mates


The CDC site is out of date very poor data for as government site



If you took the trouble to read buywells posts he says that ALL governments and agencies are trying to keep folks in the dark to stop panic