Scancell Share Discussion Threads

[ivyspivey] 17/1/2022 09:12

Morning.
Bad taste reference to Tsunami and Tonga

[oldnotwise] 17/1/2022 08:00

20.91/21.155

[inanaco] 17/1/2022 06:31

latest News

Tonga welcomes the un-vaxxed

[panama7] 17/1/2022 00:04

Wanderer, it is well and truly crumbling but the majority of posters on here will never know as it won't be covered by the MSM.

[wanderer1210_0] 16/1/2022 19:13

Wouldn't surprise me in 6 months the only people allowed to travel are the un-vaxxed, the house of cards is starting to crumble.

[panama7] 16/1/2022 18:54

Inane, if only you were free to travel to Thailand, remind me again how many times have you been there in the last 2 years, in fact how many times have you been ouside Devon in the last 2 years. How do you think the Criminal Investigation and the shutting down of va x centres will affect Scancell's covidity.

[inanaco] 16/1/2022 18:29

Pity this BB is not Australian .... P7 could have followed Jokavich

[panama7] 16/1/2022 18:05

TF, EE, WW, Inane, Gazza et al, hold on to your hats this whole V a x x i n e agenda is about to blow up big time. Vaccine centres are starting to be shut down as part of an ongoing Criminal Investigation and materials are being seized as evidence. Obviously you won't hear about it on the MSM but it's happening across the Country.

[torquayfan] 16/1/2022 12:49

Thanks Gooosed - just seen that myself. Thanks to CC and you. Impressive or what ? Quite a team coming together at the little Bio ?

[gooosed] 16/1/2022 09:52

Posted elsewhere by cc24601 :



A new recruit.

[panama7] 16/1/2022 02:26

Goosed, EricDingDong is a so called Scientific expert who blocks anyone that challenges him. You really need to look into his history and who funds him.

[oldnotwise] 14/1/2022 08:00

20.722/21.245

[gooosed] 14/1/2022 07:16

May be of interest to some - EBV was mentioned (if memory serves) in connection to Scancell some time ago.

[ammons] 13/1/2022 20:39

My reference to horse paste was not in any way serious. The detractors of ivermectin, some of whom are medical professionals, use the "horse paste" reference to rubbish the drug for use against covid.

I am referring to the Merck statement regarding ivermectin to treat covid while they were developing molnupiravir to treat covid at the same time.

[emptyend] 13/1/2022 20:30

Don't think I saw this article when it first emerged, but the WHO seems to have the right view......now we need the data on Covidity.....https://amp.theguardian.com/world/2022/jan/12/repeated-covid-boosters-not-viable-strategy-against-new-variants-who-experts-warn

[ivyspivey] 13/1/2022 20:28

Ammons my main point is at the time Merck were starting to sell billions worth of Ivermectin they were looking to develop a protease inhibitor for HIV by the name of Crixivan.
The potential was such to increase the Merck share price several fold and they knew ivermectin and all the macrocyclic lactone derivatives like eprinomectin/abamectin etc backwards.
So why would they not look at the potential for this group of drugs as a protease inhibitor as this would be picked up in initial screening.
It was also Approved for use in humans vs onchocerciasis so again it’s potential beyond animals would have been looked at.
Any Veterinary treatment should never be used in humans unless Approved for that use and they are all different formulations so injection/pour on/ drench/ paste/ bonus etc with different constituents and strengths.
In fact Mectizan the human form was very much reduced in concentration from the Veterinary ones.

[ammons] 13/1/2022 20:06

Thanks Ivyspivey. The drug is now long generic and means little in profit to Merck any more. Hence their daft statement on the drug last year while testing thier new - patented - pill to treat the same illness. No conflict of interest there, is there??? Thanks for proving my point!! Merck say it so it must be true............ At least it is for Ivy. Thanks again.

[wanderer1210_0] 13/1/2022 19:46

https://www.heraldscotland.com/news/19843315.covid-scotland-case-rates-lowest-unvaccinated-double-jabbed-elderly-drive-rise-hospital-admissions/The games nearly up! The vaccinated now predominate both cases and admissions unless recently boosted. This is probably going to go down as the biggest example of public health policy recklessness in several decades.

[ivyspivey] 13/1/2022 18:18

Evening Ammons.
Ivermectin is probably one of the most researched drugs ever within Merck and they would have conservatively earned about £25bn as a minimum from the drug.
Think it is safe to say they know pretty much everything there us to know about how the drug works and what it works against.
ATB

[ammons] 13/1/2022 16:42

Gecko, you sound like a conspiracy theorist nutter. :-)

Anyone who doesn't themselves repeat the utterings of Van Tam, Whitty, Vallance, Fauci, Pfizer or Merck executives and so on must be completely mad. What they say must be true, anything else is to be dismissed as far right trash. Even Boris has advised that anything other than the mainsteam covid narrative is "mumbo jumbo" so that is what it must be.

Ivermectin (like fluvoxamine) has never had a really big, really expensive, really complicated RCT conducted and approved by one of the big pharma companies therefore there is no evidence whatsoever to show that anyone can benefit from its use for covid infection. Its horse paste after all. More information will always be needed.

Refusing to offer any medical treatment BEFORE the patient requires hospital admission is of course one of the main (but not the only) reason why so many people died.

[geckotheglorious] 13/1/2022 15:54

Torquay

I have linked the specific video that was overly positive from JC here several times.

Here it is again, with links.

Maybe someone could let Torquay know in case he has me filtered!!


”New Pfizer drug and Ivermectin – Dr John Campbell” 22mins

New Pfizer antiviral and ivermectin, a pharmacodynamic analysis
“Modality of action exactly the same!”

New Pfizer antiviral, PF-07321332, C₂₃HS23;₂F₃N₅O₄
PF-07321332 is designed to block the activity of the SARS-CoV-2-3CL protease,
(“3CL protease” breaks down the proteins” and inhibits viral replication)

PFIZER’S NOVEL COVID-19 ORAL ANTIVIRAL TREATMENT CANDIDATE REDUCED RISK OF HOSPITALIZATION OR DEATH BY 89% IN INTERIM ANALYSIS OF PHASE 2/3 EPIC-HR STUDY
hxxps://www.pfizer.com/news/press-release/press-release-detail/pfizers-novel-covid-19-oral-antiviral-treatment-candidate

So, what is a protease?
So what is a protease inhibitor?

And, what is 3CL?
Chymotrypsin-like protease (3CL main protease, or 3CL Mpro)


Identification of SARS-CoV‑2 3CL Protease Inhibitors by a Quantitative High-Throughput Screening (3rd September 2020)
hxxps://pubs.acs.org/doi/abs/10.1021/acsptsci.0c00108#

The activity of the anti-SARS-CoV-2 viral infection was confirmed in 7 of 23 compounds



Microscopic interactions between ivermectin and key human and viral proteins involved in SARS-CoV-2 infection
hxxps://pubs.rsc.org/en/content/articlehtml/2021/cp/d1cp02967c

the strength and persistency of the interaction between IVE and the binding site of 3CLpro indicate that a partial inhibition of the catalytic activity could have place as the drug interacts with the main subdomains that define the enzyme binding pocket:
(ie Ivermectin blocks protease)


Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents


as shown in Fig. 4, out of 13 OTDs only ivermectin completely blocked ( more than 80%) the 3CLpro activity at 50 µM concentration.

Development, validation, and approval of COVID-19 specific drugs takes years. Therefore, the idea of drug repositioning, also known as repurposing, is an important strategy to control the sudden outbreak of life-threatening infectious agents that spread rapidly.


Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
hxxps://pubs.rsc.org/en/content/articlehtml/2020/ra/d0ra06379g


From the docking analysis, ivermectin showed the highest docking score with an average energy of −8.5 kcal mol−1 among all the compounds. Remdesivir showed the lowest binding energy and highest docking score of −9.9 kcal mol−1
hxxps://bnf.nice.org.uk/medicinal-forms/remdesivir.html

Ritonavir, C37H48N6O5S2 - £340/vial (UK hospital only)
Ivermectin, C48H74O14 (WHO – 6 cents a dose)

Exploring the binding efficacy of ivermectin against the key proteins of SARS-CoV-2 pathogenesis: an in silico approach (in silico – computer modelling)
hxxps://bnf.nice.org.uk/medicinal-forms/remdesivir.html

We have documented an intense binding of both ivermectin B1a and B1b isomer to the main protease with subsequent energy (ETot-) values of -384.56 and -408.6.

PF-07321332 is designed to block the activity of the SARS-CoV-2-3CL protease,
hxxps://www.pfizer.com/news/press-release/press-release-detail/pfizers-novel-covid-19-oral-antiviral-treatment-candidate


Risk of virus developing resistance to PF-07321332


Molecular Docking Reveals Ivermectin and Remdesivir as Potential Repurposed Drugs Against SARS-CoV-2
hxxps://www.frontiersin.org/articles/10.3389/fmicb.2020.592908/full


With SARS-CoV-2 S Spike protein
Ivermectin showed high binding affinity to the viral S protein as well as the human cell surface receptors ACE-2 and TMPRSS2.

In agreement to our findings, ivermectin was found to be docked between the viral spike and the ACE2 receptor

Binding Interactions of Selected Drugs With Human TMPRSS2 Protein (ACE2 protein)

The docking results revealed that ivermectin showed the highest binding affinity to the active site of the protein (MolDock score −174.971) and protein–ligand interactions

Binding Interactions of Selected Drugs With Human ACE-2 Protein that ivermectin showed the highest binding affinity to the active site of the protein (MolDock score −159.754) and protein–ligand interactions

With SARS-CoV-2 S Glycoprotein
Ivermectin showed the highest binding affinity to the predicted active site of the protein

With SARS-CoV-2 Nsp14 Protein
ivermectin showed the highest binding affinity (MolDock score −212.265) and protein–ligand interactions

Binding Interactions of Selected Drugs With SARS-CoV-2 PLpro
Ivermectin showed the highest binding affinity to the predicted active site of the protein (MolDock score −180.765) and protein–ligand interactions

A brief message to world leaders

[geckotheglorious] 13/1/2022 15:52

Torquay
"Has JC had views on 'Ivermectin' or similar that have attracted this approbrium?"

He did several videos on Ivermectin, one of them very extensive(and very positive about its use)

Which is verboten.

[inanaco] 13/1/2022 15:10

Gazza

I assume he is talking about (or somebody is) "engineered antibodies against the spike " injected into patients

they seem so ""specific"" they can't handle variants probably because you not getting a diverse range

nothing to do with vaccines