Scancell Share Discussion Threads

[ivyspivey] 13/1/2022 18:18

Evening Ammons.
Ivermectin is probably one of the most researched drugs ever within Merck and they would have conservatively earned about £25bn as a minimum from the drug.
Think it is safe to say they know pretty much everything there us to know about how the drug works and what it works against.
ATB

[ammons] 13/1/2022 16:42

Gecko, you sound like a conspiracy theorist nutter. :-)

Anyone who doesn't themselves repeat the utterings of Van Tam, Whitty, Vallance, Fauci, Pfizer or Merck executives and so on must be completely mad. What they say must be true, anything else is to be dismissed as far right trash. Even Boris has advised that anything other than the mainsteam covid narrative is "mumbo jumbo" so that is what it must be.

Ivermectin (like fluvoxamine) has never had a really big, really expensive, really complicated RCT conducted and approved by one of the big pharma companies therefore there is no evidence whatsoever to show that anyone can benefit from its use for covid infection. Its horse paste after all. More information will always be needed.

Refusing to offer any medical treatment BEFORE the patient requires hospital admission is of course one of the main (but not the only) reason why so many people died.

[geckotheglorious] 13/1/2022 15:54

Torquay

I have linked the specific video that was overly positive from JC here several times.

Here it is again, with links.

Maybe someone could let Torquay know in case he has me filtered!!


”New Pfizer drug and Ivermectin – Dr John Campbell” 22mins

New Pfizer antiviral and ivermectin, a pharmacodynamic analysis
“Modality of action exactly the same!”

New Pfizer antiviral, PF-07321332, C₂₃HS23;₂F₃N₅O₄
PF-07321332 is designed to block the activity of the SARS-CoV-2-3CL protease,
(“3CL protease” breaks down the proteins” and inhibits viral replication)

PFIZER’S NOVEL COVID-19 ORAL ANTIVIRAL TREATMENT CANDIDATE REDUCED RISK OF HOSPITALIZATION OR DEATH BY 89% IN INTERIM ANALYSIS OF PHASE 2/3 EPIC-HR STUDY
hxxps://www.pfizer.com/news/press-release/press-release-detail/pfizers-novel-covid-19-oral-antiviral-treatment-candidate

So, what is a protease?
So what is a protease inhibitor?

And, what is 3CL?
Chymotrypsin-like protease (3CL main protease, or 3CL Mpro)


Identification of SARS-CoV‑2 3CL Protease Inhibitors by a Quantitative High-Throughput Screening (3rd September 2020)
hxxps://pubs.acs.org/doi/abs/10.1021/acsptsci.0c00108#

The activity of the anti-SARS-CoV-2 viral infection was confirmed in 7 of 23 compounds



Microscopic interactions between ivermectin and key human and viral proteins involved in SARS-CoV-2 infection
hxxps://pubs.rsc.org/en/content/articlehtml/2021/cp/d1cp02967c

the strength and persistency of the interaction between IVE and the binding site of 3CLpro indicate that a partial inhibition of the catalytic activity could have place as the drug interacts with the main subdomains that define the enzyme binding pocket:
(ie Ivermectin blocks protease)


Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents


as shown in Fig. 4, out of 13 OTDs only ivermectin completely blocked ( more than 80%) the 3CLpro activity at 50 µM concentration.

Development, validation, and approval of COVID-19 specific drugs takes years. Therefore, the idea of drug repositioning, also known as repurposing, is an important strategy to control the sudden outbreak of life-threatening infectious agents that spread rapidly.


Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
hxxps://pubs.rsc.org/en/content/articlehtml/2020/ra/d0ra06379g


From the docking analysis, ivermectin showed the highest docking score with an average energy of −8.5 kcal mol−1 among all the compounds. Remdesivir showed the lowest binding energy and highest docking score of −9.9 kcal mol−1
hxxps://bnf.nice.org.uk/medicinal-forms/remdesivir.html

Ritonavir, C37H48N6O5S2 - £340/vial (UK hospital only)
Ivermectin, C48H74O14 (WHO – 6 cents a dose)

Exploring the binding efficacy of ivermectin against the key proteins of SARS-CoV-2 pathogenesis: an in silico approach (in silico – computer modelling)
hxxps://bnf.nice.org.uk/medicinal-forms/remdesivir.html

We have documented an intense binding of both ivermectin B1a and B1b isomer to the main protease with subsequent energy (ETot-) values of -384.56 and -408.6.

PF-07321332 is designed to block the activity of the SARS-CoV-2-3CL protease,
hxxps://www.pfizer.com/news/press-release/press-release-detail/pfizers-novel-covid-19-oral-antiviral-treatment-candidate


Risk of virus developing resistance to PF-07321332


Molecular Docking Reveals Ivermectin and Remdesivir as Potential Repurposed Drugs Against SARS-CoV-2
hxxps://www.frontiersin.org/articles/10.3389/fmicb.2020.592908/full


With SARS-CoV-2 S Spike protein
Ivermectin showed high binding affinity to the viral S protein as well as the human cell surface receptors ACE-2 and TMPRSS2.

In agreement to our findings, ivermectin was found to be docked between the viral spike and the ACE2 receptor

Binding Interactions of Selected Drugs With Human TMPRSS2 Protein (ACE2 protein)

The docking results revealed that ivermectin showed the highest binding affinity to the active site of the protein (MolDock score −174.971) and protein–ligand interactions

Binding Interactions of Selected Drugs With Human ACE-2 Protein that ivermectin showed the highest binding affinity to the active site of the protein (MolDock score −159.754) and protein–ligand interactions

With SARS-CoV-2 S Glycoprotein
Ivermectin showed the highest binding affinity to the predicted active site of the protein

With SARS-CoV-2 Nsp14 Protein
ivermectin showed the highest binding affinity (MolDock score −212.265) and protein–ligand interactions

Binding Interactions of Selected Drugs With SARS-CoV-2 PLpro
Ivermectin showed the highest binding affinity to the predicted active site of the protein (MolDock score −180.765) and protein–ligand interactions

A brief message to world leaders

[geckotheglorious] 13/1/2022 15:52

Torquay
"Has JC had views on 'Ivermectin' or similar that have attracted this approbrium?"

He did several videos on Ivermectin, one of them very extensive(and very positive about its use)

Which is verboten.

[inanaco] 13/1/2022 15:10

Gazza

I assume he is talking about (or somebody is) "engineered antibodies against the spike " injected into patients

they seem so ""specific"" they can't handle variants probably because you not getting a diverse range

nothing to do with vaccines

[gazza] 13/1/2022 14:59

TF,
"it'd be good to have him aware of Scancell but I'm not sure about the 10p"

You're right, make that 20p.

[emptyend] 13/1/2022 13:50

He has always had close links with Nottingham Uni.

[geckotheglorious] 13/1/2022 13:31

Moljen

I've been watching Dr Chris Martensen(PeakProsperity) since Dec 2019,and Dr John Campbell (since March 2020) and still watch both...

This is why I have the stance I have, having looked at all the data/examples/and videos these two gentlemen have produced on Covid19 since the beginning.

Hence why I have never been alarmist, or wetting my knickers!!!

Forearmed is forewarned.

[inanaco] 13/1/2022 12:28

Moljen ...it was you that then tried to defend

"t cells repair viral infected cells"

why would anyone who has followed Scancell and its science see you as a valuable contributor ???

indeed have you ever posted something USEFUL ?

what plonker posts to somebody that he has filtered ???

FFS ...

[inanaco] 13/1/2022 12:11

if he has 2,000,000 that hang on his every word ......... well done him !

but then so does Trump ... LOL

[inanaco] 13/1/2022 11:53

well that puts Lindy at the top Table .........


Professor Sir Jonathan Van-Tam will leave his role as England’s deputy chief medical officer at the end of March.

Prof Van-Tam became one of the nation’s most familiar faces during the Covid-19 pandemic after he regularly took the podium at Downing Street press conferences next to Boris Johnson and Prof Sir Chris Whitty, the Chief Medical Officer for England.

He will take up a new role as the Pro-Vice Chancellor for the faculty of medicine and health sciences at the University of Nottingham.

He said: "My time as DCMO has been the most challenging of my professional career, especially the Covid response.

"We all wish Covid had never happened. Notwithstanding, it has been the greatest privilege of my professional career to have served the people of the UK during this time."

It comes after he was knighted in the New Year Honours list for his services to public health.

[moljen] 13/1/2022 11:48

Well I see from the thread that contact has been made with Dr JC. Let's hope JC isn't a reader of this thread as when his role in the pandemic was highlighted by myself and others over a year ago a certain person though it was acceptable to, perhaps "trash" is too strong a word, question his abilities. Only a nurse, what does he know etc.

Oh I do love the irony of the situation, perhaps the contact included a rather humble apology.

[inanaco] 13/1/2022 10:54

i have sent the info ...

[gazza] 13/1/2022 10:38

Inan,

The guy gets 2M views per day. If you could get him to do a feature on Scancell it would add 10p to the share price.

[gazza] 13/1/2022 10:33

Yes, it's a good piece. He mentions T-cells, the N protein and natural immunity.
Well worth a watch. It does show how under the radar the work done by Scancell is.

[torquayfan] 13/1/2022 09:29

Well done Inan. I don't follow Dr JC much but he's a PhD (Nursing) and from the start of the Omicron wave has produced some helpful stuff from RSA experiences. His training is relevant to the 'aspiration' drum he beats and I thought it a useful idea. Good luck with your approach - perhaps he'll do a Zoom with you starring!

[inanaco] 13/1/2022 09:03

As this Dr Campbell bloke has mentioned nucleocapsid .... ref LSE

i have sent him a message via twitter and explained Scancell lets see if he takes it up

[inanaco] 13/1/2022 08:21

this all kicks off after they decide on which delivery route ...

Then i believe they can approach MHRA, because Scancells in house capabilities of testing have been and are being stepped up with the Oxford lab open, which will speed up results of the UK arm of the trial ...

1/ if the 40 patients achieve the objective and measurable response
2/ one of the guns deliver's that ....
all systems are go

if the efficacy is high ... even with small numbers the data should be scalable in a bigger trial

[inanaco] 13/1/2022 08:14

EE we are injecting 40 .... thats more than the 35 that took scib1 to get interest from Oncologists like KEITH T. FLAHERTY, MD
Massachusetts General Hospital
EDUCATIONAL TITLES
Professor, Medicine, Harvard Medical School
Director of Henri and Belinda Termeer Center for Targeted Therapy, Cancer Center, Massachusetts General Hospital
Director of Clinical Research, Cancer Center, Massachusetts General Hospital

Interested in the results

appreciate they are split between the Guns ... but the vaccine is the same, so you may get a variation in response between the guns ..... but you should still get measurable responses exactly the same way as SCIB1 delivered