Scancell Share Discussion Threads

[oldnotwise] 10/1/2022 08:02

20.385/20.8

[emptyend] 10/1/2022 07:36

Not sure how "rambling" applies to an 8 line response...... especially when your latest is 11........And, re stepone's point, Japan's societal preparedness was much better due to recent scares over SARS/MERS. Basically outside of Asia it has been a similar story across the board....some things done better, some worse, with outcomes often dependent on systems laid down decades previously, and heavily impacted by the level of global connectedness of each society.

[torquayfan] 09/1/2022 23:50

Stepone

Re. Japan - "Japan 146 dpm, another populous industrial Nation with high density areas."

Re. Germany, 1363 dpm - (62% of the UK dpm)

The UK had weeks to watch Covid emerge in Italy and were very slow to act. Also the UK was at the front of the vaccines drive.

Yet 2193 dpm. Something else was wrong IMHO.

Last post - the weekend's over. ATB

[stepone68] 09/1/2022 23:27

Why pick UK and Japan? It doesn't matter what the gov might have done differently - we were never going to get down to Japan's level. Most of Europe have similar rates to us - even Germany, and on dpm we are somewhere around 30th globally which, in terms of countries that matter, is mid-table. I remember hearing on Radio 4 in the first Summer of lockdown that Spain didn't count a death as Covid unless it was registered within 24 hours of death. Don't know if that has changed, but it makes me take all these numbers with a pinch of salt large enough that I think the Boris effect is over-stated.

StepOne

[torquayfan] 09/1/2022 22:28

Yes EE and I hope you had a Happy Sunday too and btw, you may be surprised to learn I frequently vote Tory myself - I assess it at each election based on what I see.

Sorry 'hysterical' was OTT - 'rambling' would have been better.

Returning to : " . . . . it's hard to conclude that this UK Govt has managed the Covid crisis well, despite the overwhelming advantage of being first on the vaccines track."

IMO no decisive factors have been identified to explain the difference between 2193 dpm in the UK and say, Japan 146 dpm, another populous industrial Nation with high density areas. Of course, it IS uncomfortable to think that we are not in good hands with this UK Govt. so, it's 'heads in the sand' as usual.

Myself I remain convinced that border controls, mask wearing and closure of superspreader events, have had decisive benefits in other Countries that have suffered far fewer deaths than the UK.

That's it. Back to Scancell for me now. ATB

[emptyend] 09/1/2022 16:40

Indeed you did ask that question, tf. My "hysterical"(in your opinion) response was written solely as a rebuttal of your ridiculous "question". Unfortunately your anti-Tory bigotry is preventing you from taking a rounded view of the facts - much of which have yet to emerge, as the comparators you adduced are nowhere near the end of it.I didn't vote for Boris or the Tories, by the way......Happy Sunday....

[panama7] 09/1/2022 15:20

TF, your ignorance is mind boggling. Of course the U.K has a very high death rate compared to other countries. We have carried out more tests per head of population than anywhere else. We have carried out 5 x more tests than Germany which has 20m higher population. Still after 2 years you like Inane do not understand the PCR Test. The Inventor stated that the cycle threshold for PCR is 25, anything above that is meaningless. In the U.K test centres have been running tests at 45 cycles making the results fraudulent and meaningless. We have also fundamentally changed the way deaths are reported ie anyone dying within 28 days of a fraudulent corrupt positive PCR is put down as a Covid death. Until you, Gazza, EE, WW, Inane get your head around this your posts are totally meaningless when it comes to discussing deaths from Covid.

[panama7] 09/1/2022 15:12

Roddy, in a normal flu season does everybody who turns up at Hospital for various illnesses get checked for flu using a fraudulent, corrupt PCR Test. Do patients who die of Cancer, Lung disease, Kidney failure, sepsis, RTA, get put down as dying of flu because thay were tested positive in the previous 28 days ?

[torquayfan] 09/1/2022 14:29

Yes Roddy I would have thought so too ! Your source for that ?

Whatever the data says or from whence it comes, I suppose the more important question is, what would the mortality have been without all the actions, including vaccines, against the virus . . . ?

[roddymccorley] 09/1/2022 12:53

So Covid has just double the mortality rate of the common flu ... I'm surprised I thought it would have been higher

[torquayfan] 09/1/2022 12:33

EE - "Could hardly disagree more re pandemic management." Quelle surprise !

With respect and IMHO, that's an almost hysterical reply and denial - why ?

I asked this question - "As observed before the days of hindsight, it's hard to conclude that this UK Govt has managed the Covid crisis well, despite the overwhelming advantage of being first on the vaccines track."

ATB

[torquayfan] 09/1/2022 12:26

Gazza - typical - "It's not valid not because I say so but because it is."

Oh that's alright then LOL.

Your most illogical and bizarre post - ever - and that's saying something Mr provocateur and wave rider.

No offence honestly but !!

[emptyend] 09/1/2022 12:11

tf,Could hardly disagree more re pandemic management. Not least because 1) the pandemic isn't over (especially for China and other countries still pretending, for now, that a zero covid policy is actually viable) and 2) because the basis of many countries' death figures is extremely questionable and 3) the massive health costs of shutdowns in economies are being completely ignored eg....Thailand has reimposed quarantines, thereby killing its viability as a package tourist destination for yet another year .....and New Zealand is still closed and their population is living in fear, as is Australia's (judging from the majority response to the Djokovic scam). All these countries have yet to plot any course at all for the return of normality - and at least we are starting to see a plan for that emerging in England (if not Scotland/Wales, where the local parish councillors want to keep everyone locked up - and under their control).

[gazza] 09/1/2022 11:03

TF, "Just because you proclaim the dpm comparison is not valid, does not make it so."It's not valid not because I say so but because it is. It would be like comparing the average queuing time at Sainsbury's Kensington London with Koonwarra store Victoria.

[torquayfan] 09/1/2022 10:29

Here we are again - Omicron - news coming from all directions in RSA has emphasised from the start that Omicron was milder in it's effects.

" ‘There are several things we don’t know about omicron,” a sombre Professor Sir Chris Whitty told the nation in the week before Christmas, “but all the things we do know are bad.”

His comment puzzled many people at the time, given that scientists in South Africa, where omicron was first identified, had reported that it appeared to be less severe than the then-dominant delta variant of Covid. Surely that was good news?

Three weeks on, Sir Chris’s determination to dismiss the encouraging data coming from South Africa seems even more baffling. Instead of the post-Christmas lockdown that came to be regarded almost as an inevitability, Covid rules are now being eased. The NHS did not collapse, and the number of patients requiring ventilation remains less than a quarter of the peak a year ago.

Legitimate questions are now being asked about why Britain was so dismissive of the evidence from South Africa, and whether Government scientific advisers are once again using fear as a method of control.

One of those who is doing the asking is Angelique Coetzee, chairman of the South African Medical Association and the first doctor to raise the alarm over a possible new variant, which turned out to be omicron.

Dr Coetzee was among those who reported that omicron caused “very, very mild” symptoms compared with delta, and she hypothesised that it “could potentially be of great help to us” by replacing the more dangerous delta variant and helping the population to reach herd immunity at minimal cost to life. She says she was “astonished” at the panicked response to it in the UK."

On the one hand, Whitty advises it's 'all bad' and on the other, BJ, trying to hold his feeble Govt. together, fails to muster even the merest actions to proscribe 'superspreader' events, ensuring that although Omicron is NOT too bad, we'll anyway push the NHS to the limits.

Following the science - Ha Ha ! Chaos more like.

[torquayfan] 09/1/2022 10:10

Gazza.

Just because you proclaim the dpm comparison is not valid, does not make it so.

You mention some relevant factors but IMO, these cannot explain the disparities I have mentioned and in fact, in some cases, would make the UK's comparison even worse.

Thanks for reply. BFN.

[gazza] 09/1/2022 09:36

TF, We have covered this before - comparing death rates per million across different countries is simply not valid. The approach to the pandemic will of course affect the outcome in terms of deaths, but there are far more weighty factors... Density of population Age demographic of populationHealth of population Standard of medical careAvailability of medical careEthnicity of population Cultural habitsEtc etc etc.....

[torquayfan] 09/1/2022 09:17

It's the weekend.

Into Year 3 of the Covid crisis and the the UK has crossed a tragic marker of 150,000 deaths.

In terms of 'deaths per million' the UK (2193 dpm) stands below the USA (2575 dpm)and much of S.America and E. Europe BUT still well above other major European Nations, despite Kate Bingham's massive VTF triumphs, well supported by BJ's Govt..

The UK's 2193 dpm looks sad against say, Thailand 311 dpm, Japan 146 dpm, Singapore 141 dpm, Australia 91 dpm and New Zealand 10 dpm. Of course there are differences in environmental factors around the World, but, nevertheless, these disparities, nearly 2 years hence, are mind blowing, to say the least.

Policies of border controls, mask wearing and the closure of 'superspreader' events were scorned widely and at length by some here. So I wonder if there are now any suggestions to explain these disturbing differences.

As observed before the days of hindsight, it's hard to conclude that this UK Govt has managed the Covid crisis well, despite the overwhelming advantage of being first on the vaccines track.

[panama7] 08/1/2022 20:40

Gecko, will be interesting to see how much is redacted. Not only will this shine a light on Pfizer but also the FDA & CDC. Also what needs to be called into account is the contracts Governments around the world have signed with Pfizer, that will really open the public's eyes.

[ivyspivey] 08/1/2022 16:18

Thanks Bermuda.It came from a guy called Rick so all credit should go to him.

[geckotheglorious] 08/1/2022 16:03

Dr. Suneel Dhand - MedStoic Lifestyle Medicine

Federal judge orders FDA to quickly release all Pfizer vaccine data— NOT wait decades



"He's not the only one looking forward to this data release"

[bermudashorts] 08/1/2022 15:04

Ivy,

Always difficult with limited column space to get across in layman's terms what Covidiy/ImmunoBody is all about. Think your article really does achieve that and is probably one of the best short descriptions we've seen. So thanks for posting and thanks to whoever originally posted on the other platform.

[fragma] 08/1/2022 13:20

Thanks inanaco

[ivyspivey] 08/1/2022 10:16

Morning.Don’t think this has been posted as a lot of treacle for wade through these days but no matter.
Can’t claim any credit fir finding this as posted on another platform but taken from Pharmafile Winter 21 as part of a bigger article.

“The pandemic has highlighted the growing need for DNA vaccines, in multiple areas including infectious diseases and cancer. Looking ahead to the future of healthcare during the precariousness of a pandemic, we spoke to Professor Lindy Durrant, CEO of Scancell, which develops immunotherapies simulating the body’s own immune system response. Scancell believe that DNA vaccines are one component of tackling diseases, believing the vaccines “give more sustained production of antigen which should lead to longer term protection than RNA vaccines.” This vaccination form is significant for the increasing demands and needs of global healthcare: “Dendritic cell-targeting DNA vaccines are cheap and easy to manufacture, and have long term stability at -20°C. They can be rapidly adapted to give protection against both infectious disease and cancer. They can be used for repeated injections or for injections for other viruses, whereas viral vector-based vaccines can only be used twice before the immunity to the vector overwhelms the response to the inserted virus.” For the many and varied needs presented by patients of infectious disease, this is significant.
Scancell uses a human monoclonal antibody to target cells that stimulate immune system response. This vaccine can be customised against a specific disease – a promising feature considering the changing nature of
disease we have witnessed over the past year, and even the past month. This has
the potential to change the current impact
of vaccination. “A vaccine encoding both nucleocapsid protein linked to a modified Fc and receptor-binding domain should stimulate long-term memory B and T cells, and should give sustained protection over several years. This will give less opportunities for variants to arise and prevent people from having to be vaccinated every six months.
Scancell shared that its vaccine “targets antigens to dendritic cells to give more
potent T cell responses that lead to long-term memory, and still give high titre neutralising antibody responses. The nucleocapsid protein is more highly conserved, giving better protection against variants.”
As for the future, Professor Durrant looks forward to “simpler delivery systems for DNA vaccines. Currently we use a mechanical needle free device which is acceptable, but a simple injection would be more reasonable”. Durrant also hopes for “better investment
in vaccines that give broad protection (i.e. all coronaviruses – not just COVID-19), and sustained protection for 5-10 years should be developed now so they can be rapidly adapted when the next pandemic hit“

Just thought a very good article.