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Posted at 19/3/2024 12:54 by simonsmithiv It's new business, new money, new income and a significant proportion of the company's entire market capitalisation, so of course it's significant. No doubt if they'd lost the client you'd be saying it's significant. A quick look at your posts shows you've been negative on everything PYC related for some time, and only PYC. So you've clearly got something against this company in particular and therefore your comments cannot be taken seriously. There's one on every board. Read Full Thread Reply
Posted at 18/3/2024 15:57 by davevt Because it's only 150k for 6 months work. I don't even know why pyc release and rns for doing what they are meant to do. Read Full Thread Reply
Posted at 07/1/2024 18:36 by davevt Let's unpack this.. ' Good luck engaging with the trolls here, they have been at it for years and been right for years as they will no doubt be very proud to tell you eventually. Of course when PYC does finally get rerated higher they will still be trolling here too as it's their life mission. ADVFN seems to have rather alot of their types these days.' so the people who have been right for years are trolls? And if pyc does re rate, anyone buying down here like we said is a safe level, will be thanking us. Because imagine if they listened to all the people who were telling them to buy at 7p +...the 're rate' happened and it went down, not up. This is the thing, why would it be 're rated' higher, when higher wasn't the true value and hence why it went down? Do you not see the error in your logic? If it was worth more, it would have stayed where it was. Read Full Thread Reply
Posted at 05/12/2023 18:40 by davevt That's why pyc hardly gets any business. The big pharma do what pyc do in house, and for ALL types of drugs. Pyc only does dose prediction, and only for some cancer drugs. Read Full Thread Reply
Posted at 27/9/2023 14:00 by davevt '. Make no mistake pyc jumped 100% on a 150k contract so imagine what it will do when a multi million contract lands.' Not strictly true...only a few weeks ago the price was mid 2 and we had a 1p placing...so all it did was bring the price back right to where it was. If you think contracts this company gets raises the share price, you're in for a rude awakening. And pyc can't, or ever have ' multi million contract'...pyc dictate the price, and they charge around 35k for a pre clinical model and around 120 for a clinical model...because it takes so much longer. So the only way you could have a 'million' contract, is if by sheer chance, a drug company has 30 new drugs, all at the same time, for pyc to dose predict....ignoring the fact pyc only can work on about 4 to 5 projects a year. Read Full Thread Reply
Posted at 22/9/2023 22:00 by davevt Yes, and ill repeat, pyc only charge 35k per drug, and hardly get any business because there are much larger, more advanced Biotech companies that do what pyc do, but much better, and faster, with more advanced tech...and also do it for all drugs, not only cancer drugs. Pyc has no skills for DDR. Even Merck, pycs main customer has teamed up with Artios instead to do all their DDR modelling for cancer drugs. 'Merck KGaA, Darmstadt, Germany and Artios Pharma Announce a Global Strategic Collaboration on Novel DNA Damage Response. Merck KGaA, Darmstadt, Germany and Artios will conduct collaborative research and Merck KGaA, Darmstadt, Germany shall have the right to opt into exclusive development and commercialization of compounds on up to 8 targets Artios to receive US$30 million in up-front and near-term payments, plus double-digit option fees and up to US$860 million total milestones per target Collaboration to leverage significant expertise and R&D resources of Merck KGaA, Darmstadt, Germany in the field of DNA Damage Response to identify and develop precision oncology medicines targeting nucleases ' Remember, pycs tech is very antiquated. Their virtual tumour software is twenty years old. You weren't even aware cruk was an existing client, admit it. Read Full Thread Reply
Posted at 22/9/2023 20:33 by davevt It doesn't matter what CRUK have, pyc charge around £35k per drug they are asked to dose. CRUK have used pyc twice in the past 5 years, and neither of them, we know if pyc even charged them. Do the math. Why do you think pyc does such low revenues. It's only a 35 grand service. Read Full Thread Reply
Posted at 10/9/2023 19:12 by davevt ' This is simply not true. The FDA have approved 25 new cancer drugs for commercial sale just this year alone.' I'm confused how you are arguing with me. You're literally arguing semantics of the word 'invented'....and then tell us only 25 drugs have succeeded...across ALL pharmas, across all of the USA...and for a drug to be approved 'this year' means it would have been first trialed years ago. If a drug isn't invented, it can't make it to a trial to require pyc to dose it. I'm not sure what you're trying to argue. Surely you don't think if pyc got 25 new clients on board, they all have a new cancer drug, every year? Pyc could get a client to agree to work with them...doesn't mean that client has anything in the pipeline at present for them. Once again, FDA is irrelevant to pyc, all of their customers are European / uk, so do not require FDA approval. Once again, if you look at pycs history, they manage to get a new customer on board every couple of years...but we also realise that previous customers we never hear from again. Currently it seems pyc have about 4 to 5 customers...but again, hard to tell...because they may have customers that simply haven't got anything oncology wise in the pipeline..so we don't see new work being undertaken. Read Full Thread Reply
Posted at 08/9/2023 11:09 by davevt ' A biotech company approaches a computer modeller like PYC and says - "this is our early stage drug davevt1234X that comprises of compounds A, B and C. Tell us what is the optimal dosage for customer E that suffers from condition F". Computer modelling companies have a wealth of data and in the case of PYC 20 years worth. So unless the biotech company has discovered a new element that nobody has ever come across the computer model will be able to predict the outcome of the compounds on the patient.' If that was true, it wouldn't take them, as they have stated, on average 3 months to create a model. It works by the client having to give them lots of data, and if it doesn't get the desired results, they will use their findings to go back and improve the model. Those last two sentences I'm literally quoting from Jim as I remember him saying it in a video. this isn't my 'opinion'. This is why the pricing is cheap, as without the clients, pyc can't build a model. Remember, pycs virtual tumour system is over 2 decades old, it's antiquated in the grand scheme of things. And NO, it's not for 'customer e that suffers from f...that is only for personalized dosing. All of the contracts you see are for non personalized...just general optimized dosing. Read Full Thread Reply
Posted at 08/9/2023 10:26 by davevt ' You've got this back to front. If they're feeding in data from a clinical trial to see if their computer comes up with the same results then that is not computer modelling, that's simply data analysis. The new guidance from the FCA is that they want to see results from computer modelling before they approve clinical trials.' Totally correct. Pyc do not do what you think they do. Think about it. Say a company comes to pyc and says 'hi, we want you to dose predict our new drug'...how the hell can pyc do anything without having data about how the drug works in the first place... Pyc will build a model of their prediction, give it to the client, and the client will run it along side their manual trial, and what the end result was, and who got the best one. If pycs prediction was top, they may get repeat work, if pycs model wasn't as good as the manual trial, pyc will then take the data and results from the trial to improve their model. The computers aren't psychic dude. It can't just model predict out of thin air. Maybe you're not aware, but the drugs pyc work on have 'already' been created and are known to work. All pyc is doing is trying to work out an 'optimum' dose. the drug company already has data on general dosing that works, and will give that data to pyc. Read Full Thread Reply