Optibiotix Health Share Discussion Threads

[manc10] 09/3/2021 12:59

comment from #OPTI CEO Stephen O'Hara; "More to come."

"This reflects the success we had last year and is a real vindication of SlimBiome as it takes a lot for a retailer to take on someone else’s product and launch an own brand." 😊😊

[manc10] 09/3/2021 12:39

ray they have added another six products because they dont sell any loooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooool

[manc10] 09/3/2021 11:42

[...] MORE PRODUCTS WITH SLIMBIOME AT H AND B check out slim expert

[tonyevo256] 08/3/2021 22:29

Coz the dopey knut shorted at 29p and now needs them back there to save his hole from being shafted..you could always stick some bum cream on if it hurts too much.. hang on isnt there another dopey kunt on the SBTX board call 29p..hmmmm I wonder...

[slartybartfaster] 08/3/2021 19:40

Yes, it broke through 30p and held. Woooooooooooow

[kreature] 08/3/2021 18:31

Trend line broken over at sbtx right ?

[slartybartfaster] 08/3/2021 14:37

How original. You missed the opportunity all the way up from 5p. So why 29p. Woooooooooooooow

[manc10] 08/3/2021 14:12

The mouth hosts a variety of microbes: bacteria, protozoans, viruses and fungi. Bacteria dominate, and some act as gatekeepers of the mouth, protecting us from pathogens. Practices like vaping, however, can throw off the oral microbiome's delicate balance, leading to health concerns for the mouth and the rest of the body.

"It's not Vegas. What happens in the mouth doesn't stay in the mouth," said Purnima Kumar, professor of periodontology at The Ohio State University. "The mouth is the gateway to the body and because of that there is a pretty large and very vibrant, very dynamic and diverse microbial ecosystem."

Last Spring, Kumar and her team published a study in Science Advances showing that vaping devices or electronic cigarettes (e-cigarettes) impact that ecosystem. Now, they're trying to figure out how e-cigarettes do it.

Kumar's group had been studying smoking cessation aids, like vaping devices, and grew curious about what, if anything, they might do to the mouth's bacteria. The oral microbiome comprises several ecosystems, and Kumar’s team zoomed in on one of them, the bacteria beneath the gums. In their Science Advances study, the researchers analyzed genetic profiles of plaque samples from 123 people — 25 smokers, 25 nonsmokers, 20 e-cigarette users, 25 former smokers using e-cigarettes and 28 people using both e-cigarettes and cigarettes.

Studying the genes could tell the researchers what bacterial functions in the oral microbiome may differ between the groups. During the study all participants were healthy with no gum disease or active cavities.

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Analyzing plaque samples from under the gums, the researchers saw that e-cigarette users were clearly distinct from other subjects. "When we looked at what is different, we found that these bacteria [from e-cigarette users] had high levels of stress, very high levels of stress, and they respond to the stress by producing this slime layer," said Kumar. The bacteria also secreted toxins that destroy host cells and prevent other bacteria from colonizing.

E-cigarettes seemed to create more favorable conditions for virulent bacteria compared to nonsmokers or cigarette-only smokers. The immune system was also responding to these conditions. "We found a huge spike in inflammatory mediators," said Kumar.

As part of the Science Advances study, Kumar’s team also created artificial oral biofilms, or mats of bacteria, to get a more detailed picture of how e-cigarettes affect oral bacteria. They exposed different samples to clean air or puffs from nicotine-containing and nicotine-free e-cigarettes, and allowed the biofilms to grow. Their findings aligned with the human observations.

Perhaps most concerning for long-term health consequences, the study revealed that healthy e-cigarette users had pathogen representation and inflammation on par with people with severe periodontitis or gum disease. In periodontitis, plaque and tartar build up in the pocket between the tooth and the gum. The pocket grows deeper as disease progresses, and the infection damages the supporting bone.

Since this work showed that e-cigarettes, with or without nicotine, could perturb the microbiome, the research team thought that glycerol and glycol, common e-cigarette components, might set these devices apart from cigarettes or clean air.

Glycerol and glycol are used widely in food products safely, but are used to carry flavors and create vapor in e-cigarettes. "The problem is when you heat them to high temperatures they start breaking down into unexpected compounds," said Kumar, like formaldehyde.

At the American Association for the Advancement of Science annual meeting in February, Michelle Scott, a graduate fellow at The Ohio State University who works with Kumar, presented the group’s recent research showing which e-cigarette components might have the heaviest influence over the oral microbiome.

Similar to their previous study, Scott and her team exposed bacteria to clean air or puffs from nicotine-containing and nicotine-free e-cigarettes, and analyzed the resulting biofilms. Both types of e-cigarette encouraged growth of more virulent, or disease-causing, bacteria and increased biofilm mass.

This preliminary research suggests that the bacteria love glycerol and glycol. "The bacteria are eating it, looking at it like hamburgers, fast food," said Kumar. With that rich food source, bacteria thrive.

Kumar's work is, however, just a small snapshot of the e-cigarette-oral microbiome relationship, and this research area is in its infancy. Another group has also found that e-cigarettes appear to change the oral ecosystem, but research with larger samples following people over periods of time are needed.

Scientists don't yet know what e-cigarette's effects on the oral microbiome mean for health. But given preliminary findings that these devices create gum disease-like conditions, Kumar is concerned for the long-term public health impact of periodontitis and other chronic diseases. Gum disease is associated with a disrupted oral microbiome, and the disease has also been associated with an increased risk of heart attack and dementia later in life.

Scientists also know that the oral microbiome is associated with chronic diseases that affect other parts of the body. When something disrupts the balance of microbes in the oral microbiome (a disturbance called dysbiosis), those microbes release large amounts of toxins, triggering inflammation. As part of the inflammatory response, blood vessels become leaky, allowing the bacteria and toxins to enter the bloodstream.

"That translocation of bacteria, bacterial products and inflammatory mediators, all of them can lead to non-infectious diseases elsewhere in the body, or at least exacerbate noninfectious diseases in the body," said Kumar. For example, dysbiosis in the oral microbiome has been associated with kidney disease, Alzheimer's disease, rheumatoid arthritis, diabetes and cardiovascular disease.

No one has yet shown that vaping causes these issues, but scientists don’t know all the risks that come with e-cigarette use either.

"When I was doing work on smoking cessation, vaping seemed like a godsend," said Kumar. And if people can use these devices to quit smoking, and then gradually wean themselves off of e-cigarettes, that's a win. "But the issue is this: The act of vaping itself, with or without nicotine, does change what's in your mouth."

[kreature] 08/3/2021 14:04

buy orders at 29p at sbtx