Open Orphan Share Discussion Threads

[discojames] 07/12/2020 08:16

It's hardly muted! Moving up pretty fast and coinciding with a big potential break out on the charts

[judijudi] 07/12/2020 08:11

A bit muted as no figures attached
All looking good though
Happy to be holding

[666james] 07/12/2020 08:08

all very quiet here........all wondering what the share price will do with the news of yet more contracts. Just tried a sale and was offered 24p

[talkman2] 07/12/2020 07:56

I wonder .

[1gw] 07/12/2020 07:55

Let's hope the market responds "appropriately".

[digger2779] 07/12/2020 07:42

Glad we are out of the news drought lol. Here's to some positive action!!!

[molatovkid] 07/12/2020 07:41

....or volunteers for the clinics !

[readdin] 07/12/2020 07:35

More coal for the fire

[bobsworth] 07/12/2020 07:29

Great News for the share price me thinks!

Nice one Cathal

[owenski] 07/12/2020 07:17

Great statement -

"I am very excited by the momentum in the business and look forward to providing further updates in the weeks and months ahead of what is going to be a very exciting 2021".

Looks like ORPH is moving beyond the physical boundaries of it's East London venue, not straightforward to value the business on just a number of beds occupied anymore.

Feeling more like there's a franchising element to the business coming.

[talkman2] 07/12/2020 07:16

It’s about time this re-rated to a higher and more realistic share price level. Great news.

[rivaldo] 07/12/2020 07:14

Great news - two big new contract wins. The first in particular shows ORPH's global capabilities:

"The first contract, which will commence immediately, is a COVID-19 study for a European pharmaceutical company which involves 200 patients in 50 sites across 5 countries around the world."

And some typically positive closing comments from Cathal - more updates to come:

"I am very excited by the momentum in the business and look forward to providing further updates in the weeks and months ahead of what is going to be a very exciting 2021"."

[rafboy] 07/12/2020 07:14

Yes good RNS.

[molatovkid] 07/12/2020 07:13

Here we go, a Techinvest buy rec. & now a money spinning RNS. Fantastic stuff.

'A very exciting 2021'....I'll be there.

Loving the volunteer advert at the end of the RNS.....never seen that before. LOL! The guy has some chutzpah!

[judijudi] 07/12/2020 07:06

Nice 👏👏

[warranty] 06/12/2020 23:14

Re the possibility of Brexit having a negative effect on Orph, I would have thought that as an Irish company there would possibly be little or no effect?

[malcolmmm] 06/12/2020 20:38

Not new-

Open Orphan comprises of two commercial specialist CRO services businesses, hVIVO and Venn Life Sciences and is also building out a valuable data platform business. hVIVO has built up one of the world’s largest databases of infectious disease progression data and we are populating our Open Orphan Health Data platform with this historical hVIVO data. In our clinical trials going forward, we are also planning to collect data on volunteer’s via WEARABLES

during clinical trials. Therefore, Open Orphan’s data, which may yield valuable digital biomarkers, could be one of the more sought-after datasets by many of the large wearables /smart watch wearables providers around the world. In June 2019, Open Orphan acquired AIM-listed Venn Life Sciences Holdings plc in a reverse take-over and in January 2020 it completed the merger with hVIVO plc in January 2020. Venn is an integrated drug development consultancy firm which offers CMC (chemistry, manufacturing and controls), preclinical, Phase I & II clinical trials design and execution. The merger with hVIVO created a European full pharma services company broadening the Company’s customer base and with complementary specialist CRO services, widened the range of the Company’s service offerings.

[nickthe saint] 06/12/2020 20:19

All,

Interesting to see that H5N8 Bird Flu outbreak is now coinciding with all things Covid.

For those people less familiar with this, Bird Flu is highly likely to produce a virulent and potent strain in the next 20 years which is likely to provide another Pandemic Flu situation very much like the current Covid-19 one.

Seasonal Bird Flu occurs nearly every year from the Chinese based Wet Livestock markets where transmission between Birds is easily achieved, but only becomes a problem when the virus mutates and transmits from Birds to humans - this does not seem to happen every year that it jumps species but it does every few years.

Bottom line is many Poultry Farms in Norfolk and other areas of UK having to cull their livestock.

Let's hope this doesn't mutate and/or mix with Covid or all current vaccines would have to be reworked.

Also mink Farms in Denmark now are being required to dig up and incinerate all culled Minks as there is a risk of virus spreading through soil and ground water into potential livestock feed etc.

Avian Flu has so far failed to either be virulent enough or potent enough to be a significant problem, but it will...eventually.

Governments increasingly need to be ready for this.

Regards

NTS

[nickthe saint] 06/12/2020 20:05

Hi Extrader,

Thanks.

I have shown below the Pfizer quote but 95% success is like giving 2000 trial patients placebo and 2000 the vaccine and sending them out into the community to carry on "as normal".

if 100 of the placebo group contract Covid you would expect only 5 in the vaccine group to contract Covid. This equates to 95% not contracting Covid who were vaccinated (non placebo group).

I use round numbers above but the Pfizer quote below is mathematically pro rata.


"Pfizer said on Wednesday there had been 170 cases of the disease in its trial of more 43,000 volunteers, of which 162 were observed in the placebo arm and 8 were in the vaccine group."

Hope that helps

Regs

NTS

[m5] 06/12/2020 18:58

Good posts. What’s the betting that this will not be 23p come the end of the month. Personally think we are in for a cracking end to the year. DYOR.

[trader_3] 06/12/2020 15:15

China CHIM licensing & Covid vaccine testing

Following on from my previous post, Cathal’s clearly been in discussion’s with China for some time now and has three Chinese Covid vaccines in the pipeline.

120620

“Friel is currently in talks over running challenge trials for a dozen COVID-19 vaccine developers in Europe, North America, and Asia, three of which are from China.”

hxxps://www.chinadaily.com.cn/a/202006/12/WS5ee2dbeda3108348172528b9_1.html

I believe there are now two routes to market in China, for ORPH:

1. Testing Chinese Covid vaccines via CHIM’s

2. Expansion and licensing of Covid & non Covid CHIM models

Either of these would bring significant recurring revenue streams, in addition to everything else.

IMHO

[trader_3] 06/12/2020 13:34

China Daily article with Dr Andrew Catchpole, hVIVO

‘Chinese manufacturers have several vaccine candidates in the pipeline that do not require ultra-cold storage, including a treatment developed by Sinovac that produced a strong immune response in Phase 1 and Phase 2 testing, with results from largescale Phase 3 testing coming soon.

Vaccine makers from China have already agreed to deliver tens of millions of doses to numerous developing nations around the globe.

"Really, the way we are going to deal with this pandemic globally is by having a variety of vaccines available using different technologies, and, crucially, some of those need to not have cold-chain issues," said Andrew Catchpole, chief scientist at London-based vaccine testing lab hVIVO. "And this is not uncommon, most infectious diseases for which we have vaccines are actually collectively delivered by a number of different vaccine manufacturers”….

….."We are seeing more vaccine hesitancy, because people are questioning how a vaccine can be licensed to the market and be safe within that sort of timeframe, when we all know prior to the pandemic it takes many years," said Catchpole, who has had direct involvement with UK regulators on COVID-19 clinical trials.

"People need to understand that anything to do with COVID that lands on the regulator's desk is sent to the top of the pile," Catchpole said. "We need to reassure people there have not been shortcuts taken in the approvals of these vaccines. What we are seeing is a massive expediting of the processes."

hxxps://www.chinadaily.com.cn/a/202012/03/WS5fc8550ba31024ad0ba99941_2.html

(N.B. China Daily is an English-language daily newspaper owned by the Publicity Department of the Chinese Communist Party and has the widest print circulation of any English-language newspaper in China.)

Didn’t Cathal mention something about talking to the Chinese government and a potential large lucrative Chinese contract in the pipeline?

Here it is…!



GLA LTH’s

[supernumerary] 06/12/2020 12:09

Interview with the NIH's top vaccine man. He wants the world to prepare prototype vaccines for all the known human-infecting viruses. Vaccinology is not going away any time soon...

[molatovkid] 06/12/2020 11:54

Excellent news from Techinvest - great find

[malcolmmm] 06/12/2020 11:03

Pfizer side effects, head aches , fatigue, aches and Pains. Moderna ,the same but the dose is 3x that of Oxford. The Queen should wait for the Oxford vaccine.