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Share Name Share Symbol Market Type Share ISIN Share Description
Open Orphan Plc LSE:ORPH London Ordinary Share GB00B9275X97 ORD 0.1P
  Price Change % Change Share Price Bid Price Offer Price High Price Low Price Open Price Shares Traded Last Trade
  -0.25 -1.01% 24.50 24.00 25.00 24.75 24.50 24.75 339,436 08:29:22
Industry Sector Turnover (m) Profit (m) EPS - Basic PE Ratio Market Cap (m)
Health Care Equipment & Services 3.3 -5.6 -3.4 - 164

Open Orphan Share Discussion Threads

Showing 9901 to 9922 of 12250 messages
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DateSubjectAuthorDiscuss
25/11/2020
00:14
If 10,000 volunteers were given a covid vaccine and a year from now some started to fall ill due to side effects as has happened in the past with vaccines, what then? As far as I am concerned governments should not allow this sort of hit and miss method risking many hero's Far better imo to have safe carefully monitored challenge tests using a mild form of the virus on a few medically checked individuals. Even WHO says it is an acceptable method.
malcolmmm
24/11/2020
22:29
Supernumerary, your response much appreciated and understood and Pierre, apologies if I got your comments wrong.
warranty
24/11/2020
19:27
The challenge studies will not only provide important evidence of how the vaccines work under different circumstances, age, physical health, etc individuals who have specific needs eg diabetes or other such illnesses but the data that will be acquired will be extremely valuable when negotiating the sale or leasing to a wearable companies.Don't forget that the more data that is acquired the more valuable it becomes.
wreckage
24/11/2020
19:08
Just remember SGS will have to be paid They ain’t the government
systagenix
24/11/2020
18:59
warranty 'Given that we now have 3 working vaccines, which were produced within months without the high risk of actually infecting people in a Challenge Trial, will the government continue with the tests?' Firstly the risk in a challenge study is lower than in vaccinating 20,000 people in the wider population and waiting to see what happens. In the challenge study they're carefully selected, carefully watched, and carefully treated should that become necessary. In the wider population study they're left to their own devices until they get visibly ill. If they don't get visibly ill, then they're completely ignored other than as statistics :( Secondly, a 'working vaccine' is a moving target. See this for instance: https://www.fiercebiotech.com/biotech/astrazeneca-probes-mistake-behind-90-covid-vaccine-efficacy It turns out that the optimum dose dosing schedule for the AZ vaccine was a mistake! Now they 'plan to do more research in the coming weeks to understand the mechanism'. Wouldn't it make sense to do that in a properly controlled trial rather than in another one with many thousands of patients? Or even in a series of properly controlled trials? Perhaps the other vaccine companies are also beginning to find anomalies in their results that they'd like to investigate further? That certainly wouldn't surprise me. So, in answer to your question, and making all due allowance for the ineffable stupidity of our government, I think the answer to your question is no, they won't cancel.
supernumerary
24/11/2020
18:41
The case in support of CHIMS out today: hTTps://www.cbc.ca/news/opinion/opinion-human-challenge-trials-covid-19-vaccine-1.5812455
davew28
24/11/2020
18:10
Warranty, I'm afraid filtered. It's just monotous raising exactly the same negative points every time a vaccine results are published. If you are so worried and concerned maybe you should sell up or reduce your risk as you are becoming monotously boring and contributing nothing new. I welcome positive and negative but we have heard your concerns multiple times.
davew28
24/11/2020
17:58
Warranty, Just got to the 'hostile' comment. Are you for real? ffs mate.
pierre oreilly
24/11/2020
17:31
Warranty did you look at the article on the new vaccines and the presentation from CF last week they spell out exactly the direction of CV19 challenge studies, in my opinion the chances of the government cancelling are so remote as to be negligible. DYOR, please, I can be wrong my opinions are my own.
pogue
24/11/2020
17:28
The challenge studies are there to provide assurance/proof that the vaccines work in all circumstances and ages and any side effects caused should show up in a short space of time rather than years down the line. With out any vaccines to challenge ORPH wouldn't have much work . By vaccinating huge amounts of volunteer's in the first place is extremely risky without controlled challenge studies anyway. There are lots more vaccines in the pipeline so surly much safer, quicker and cheaper to carry out challenge studies on a few rather than just vaccinate thousands.
malcolmmm
24/11/2020
17:26
Crusader it will be non CV19 challenge studies at the rented/JV or however its structured facility in Belgium its in the latest presentation posted here today seems there is loads of work in that area.
pogue
24/11/2020
17:08
👏👏👏👏 8079;
judijudi
24/11/2020
16:56
Pierre, once again you don’t appear to have read my point properly and gone off in all manner of different directions. It was specifically linked to the 3 COVID CHIMs the government has paid the deposit on. Given that we now have 3 working vaccines, which were produced within months without the high risk of actually infecting people in a Challenge Trial, will the government continue with the tests? I’m not saying there won’t be other Challenge Trials, of course there will, hopefully lots of them in the next decade as CF has said, which Hvivo should benefit from, so it appears that your answer is no, you don’t think the government will cancel them. Great, that’s all I asked so can we please stop this hostile attitude against anyone who dares to ask a legitimate question to the posters on this board, most of who’s posts I respect greatly. We’re all in this to prosper, we all believe in CF, so please just lighten up a bit.
warranty
24/11/2020
16:43
So if memory is correct, fully booked 24 bed unit annual income was expected @ £45m, the website presentation indicates breakeven with revenue of £13m (£10m fixed, £3m variable) and looks like ongoing variable costs run around 20%, so annual gross profit looks to be around £25.6m? If you assumed that the Royal Free (19 beds) and potential 3rd facility (45 beds) returned similar amount as a minimum, then gross profit next year around £76.8m from these 3 facilities alone? Covid CHIMs obviously have a higher price and no/low fixed costs incurred at Royal Free, but take longer than non-covid CHIMs. Unclear as to what type CHIMs would take place at potential 3rd facility or whether entire facility would be available or at what cost, hence basic assumption equal to current facility at a minimum? Overly simplistic I know, but does it seem reasonable?
crusader5
24/11/2020
16:10
No problem everybody. I appreciate all the good contributions, if I can find the odd peice it all helps.
toyin
24/11/2020
16:03
nice find toyin...thanks
666james
24/11/2020
15:57
Thanks toyin...He seems to be more and more assured on each presentation. The third facility sounds very close to an announcement.
marvelman
24/11/2020
15:55
Lako - it was range bound like this in Aug/Sep until it suddenly took off. At least we have a decent wedge forming.
wassapper
24/11/2020
15:51
Not much buying so sellers dictating I’m afraid
judijudi
24/11/2020
15:43
I have never known this share to be so up and down on a daily and weekly basis.
lako42
24/11/2020
15:25
Toy - good find. Cashed up, company expansion, poss buy out option Spring '21, wearables deal, Imutex, growing sector etc etc Forward ~ 7 min 20 secs ‘In the short term you’ll see an announcement, we’ll have access to a third facility, we’ve so much work’ SGS RNS soon?
trader_3
24/11/2020
14:50
I think because we have been told we have these vaccines, a lot of people have just moved on from covid, they think its a slam dunk. Timetable has already changed and change it will again IMHO. Testing will still be required for a long time and covid is not going away, that is generally accepted. I see "green shares" flavour of the day, are on the move today and gold shares have fallen back. I have topped up on a few as when the reality of this pandemic truly hits home, people will once again be looking for a safe place for their money. Another reason why I like ORPH. CF sees its huge growth potential or I am 100% sure he would have been off, sack full of money, derisked, and onto the next.
m5
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