Open Orphan Share Discussion Threads

[pierre oreilly] 24/11/2020 14:18

Would this help warranty. Flu challenge studies have been ongoing since the early 1940s. They've had flu vaccines since 1945 (thanks to challenge studies in the couple of years before, incidentally done by deptartments now subsumed by and part of hvivo).
Flu challenge studies are still on going today.

[m5] 24/11/2020 14:15

I know it all sounds ramptastic!! We know nothing is 100%,and everybody should make their own decisions and do their own research, but I do keep looking for a downside to this and I am struggling. I think CF saw the same, pretty early doors, and that's why he is going on for the ride and to extract maximum value. I think he is pretty ruthless underneath it all, if he felt it wasn't worth his while, in a big way, he would have been onto the next. IMHO.

[pierre oreilly] 24/11/2020 14:12

lol! What a time for me to pop up! 8595 wasn't there when i started writing 8596

[pierre oreilly] 24/11/2020 14:10

Warranty, really mate, the questions you ask are sort of non-questions. It just seems to show a lack of following of everything challenge studies, orph, vaccines, authorisations and everything surrounding the area is about.

You seem to assume with 3 vaccines (let's assume they all get approved) challenge studies are not necessary. Or at the very least you must think there's a possibility they're no longer necessary. I honestly can't think how or why you could think having 3 vaccines renders callenge studies, or even covid challenge studies, unnecessary.

Even if 140 vaccine candidates get approved, hvivo will still be fully booked and turning away challenge studies for the foreseeable future.

I just don't see how you can link a successful covid vaccine to no more challenge studies (or even no more covid challenge studies). The world isn't going to stop once there's a covid vaccine. Soz i can't answer better. If you could say why you think there's a link it may help to answer better.

[pogue] 24/11/2020 14:01

m5
you me and Pierre say the same things all the time on this share, very worrying lol

[pogue] 24/11/2020 13:57

Warranty
read the link toyin has put up, as should others, it proves how much testing will be required going forward of vaccines that might actually work.

[m5] 24/11/2020 13:53

You beat me to it pogue. Its all there if you listen.

[pogue] 24/11/2020 13:48

warranty
listen to the presentation from Thursday from Proactive.

[warranty] 24/11/2020 13:34

Right, don’t shoot me down for this or accuse of decamping or negativity because I’m fully invested and behind Orph and this is a genuine question. is there a possibility that even after paying a deposit for COVID CHIMs, the government pulls out and leans on the regulator to reject our authorisation due to the fact there are now 3 confirmed vaccines? These vaccines have been delivered in months through normal, but hastened testing and without the potential dangers to life and wellbeing of actually infecting volunteers with the virus through CHIMs, even a reduced dose? Secondly, will volunteers now still be willing to take part knowing a vaccine has now been found? I fully accept that Orph isn’t just a COVID play but I suspect the share price has risen mainly due to that despite the additional opportunities from Immutex and wearables?

[m5] 24/11/2020 13:13

Sorry forget that link.

[m5] 24/11/2020 13:08

bramble13, thank you, I certainly will.

[judijudi] 24/11/2020 12:48

Surprised at the selling to be honest

[bramble13] 24/11/2020 12:41

M5 please do an in depth research on Ergomed. You will never regret in. You you wanted a company as good as ORPh ,there's one for you.

[bramble13] 24/11/2020 12:36

M5...an other excellent pharma company is ergomed ERGO

[trader_3] 24/11/2020 11:47

Oxford Covid vaccine - Prof Pollard - HIC Vac - ORPH


Professer Andrew Pollard is the lead for the Oxford Astra Covid vaccine:



He is also the director of the HIC Vac network that aims to accelerate the development of vaccines globally utilising CHIM’s:

hxxps://www.hic-vac.org/

ORPH’s recent RNS confirm’s collaboration with HicVac:



Based on the above, I would guess an Oxford vaccine CHIM study, would be highly likely in the New Year.

This would be great kudos for ORPH and likely to generate more head to head CHIM’s in the future.

IMHO

[trader_3] 24/11/2020 11:10

Oxford Covid vaccine hit 90% success rate thanks to dosing error



If a 90% success rate was achieved by a ‘dosing error’, how valuable would a human challenge trial be, in establishing correct dosages and timings for all the new Covid vaccines?

[m5] 24/11/2020 10:58

Still think we are being hit with the covid stick here. We know covid IS not going away and I see rollout has been put back to April/Easter, what a shocker-NOT. What is the betting it goes further back? Blatant BS, but I get why they did it.

As we have said before golden opportunity for fresh investors to climb onboard if they can be bothered to do an hours research. What did CF say?, this area has been vastly underfunded for 30 years? Money know being thrown at it and guess who is right at the top of the tree for testing. It's not rocket science is it?

Then we have the non core stuff, oh well, you can lead a horse to a water and all that............

News on a deal on wearables and this doubles IMHO. I think its going to be that big. Looks like a licensing out deal with recurring revenue, total transparency in revenue streams, from the biggest players on the planet, that are awash with cash. I think the market and investors will love that as we come into an era of great uncertainty.
I know it sounds rampy, but with what we already know, talking to 10 majors right now, tell me I am wrong. They approached us remember.

[extrader] 24/11/2020 10:50

Hi all,

A bit more about where Elaine's a NED

hxxps://www.ipgroupplc.com/


IPO goals in ORPH's space :

.."3.3 By 2030, end the epidemics of AIDS, tuberculosis, malaria and neglected tropical diseases and combat hepatitis, water-borne diseases and other communicable diseases
3.4 By 2030, reduce by one third premature mortality from non-communicable diseases and promote mental health and well being
3.D Strengthen the capacity for early warning, risk reduction and management of national and global health risks.

That network effect, again...
ATB

[malcolmmm] 24/11/2020 10:26

Hopefully a wearables contract before Xmas.

Elaine Sullivan will replace the departing Mark Warne as an independent member of the board.

Currently chief executive Curadh Pharmaceuticals, she brings with her big company experience, having held senior R&D posts at Lilly and AstraZeneca, as well as an “in-depth background and knowledge” of virology.

The latter in particular will be helpful at Open Orphan, which is cementing its place as the world leader in the testing of vaccines and antivirals using human challenge clinical trials.

“[Elaine’;s] level of expertise in virology alongside her exceptional career in the industry will be an excellent addition to the company,” said chairman Cathal Friel in a statement.

[stewart4990] 24/11/2020 10:25

Laz,

Fully agree on eme, I have not as many as a number of shareholders but 1 Million would be near for my holding.

I bought in here 10 days ago and will look to add more if BPC or eme increase.

[judijudi] 24/11/2020 09:56

Both potentially good investments at the current prices
I have also had a nice nibble over at DVRG. Great potential given the current issues (although possibly 🤷‍a94;️ a greedyish CEO)
imho
Which we’re used to anyway Laz 😃
Sorry for O/T

[m5] 24/11/2020 09:32

Saved. :-)

[lazarus2010] 24/11/2020 09:30

m5, say it again, EME has the potential to double before Christmas and then 20 bag (yes twenty bag) over the following 12-24 months. Save this post and refer back in 2 years ;-)

[m5] 24/11/2020 09:23

Nice appointment. Whilst I am a great believer in doing your own thing, having a plan, why would you sell at the moment? I still can't find anything out there that even tempts me to switch. Great upside and defensive qualities in a uncertain and volatile market place.

If anyone sees anything else that does, please let me know. Seriously.