ADVFN Logo

We could not find any results for:
Make sure your spelling is correct or try broadening your search.

Trending Now

Toplists

It looks like you aren't logged in.
Click the button below to log in and view your recent history.

Hot Features

Registration Strip Icon for charts Register for streaming realtime charts, analysis tools, and prices.

OKYO Okyo Pharma Limited

91.00
0.00 (0.00%)
Last Updated: 00:00:00
Delayed by 15 minutes
Share Name Share Symbol Market Type Share ISIN Share Description
Okyo Pharma Limited LSE:OKYO London Ordinary Share GG00BD3FV870 ORD NPV
  Price Change % Change Share Price Bid Price Offer Price High Price Low Price Open Price Shares Traded Last Trade
  0.00 0.00% 91.00 1.20 1.60 0.00 00:00:00
Industry Sector Turnover Profit EPS - Basic PE Ratio Market Cap
0 0 N/A 0

OKYO Pharma Limited Filing patent application for the use of Chemerin (0415M)

19/01/2021 7:00am

UK Regulatory


Okyo Pharma (LSE:OKYO)
Historical Stock Chart


From Mar 2019 to Mar 2024

Click Here for more Okyo Pharma Charts.

TIDMOKYO

RNS Number : 0415M

OKYO Pharma Limited

19 January 2021

NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION, IN WHOLE OR IN PART, IN OR INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OF SUCH JURISDICTION

THIS ANNOUNCEMENT CONTAINS INSIDE INFORMATION FOR THE PURPOSES OF ARTICLE 7 OF REGULATION (EU) NO 596/2014

OKYO Pharma Limited

("OKYO" or the "Company")

OKYO announces filing of a patent application covering the use of Chemerin and associated analogues to treat "cytokine storm" associated with COVID-19 and ARDS

London and Boston, MA, January 19, 2021 - OKYO (LSE: OKYO; OTCQB: EMMLF), the life sciences and biotechnology company focused on the discovery and development of novel molecules to treat inflammatory dry eye diseases and chronic pain, announces that it has today submitted a patent application for the potential use of chemerin and chemerin analogues for prophylaxis against and treatment of symptoms associated with, or resulting from, infection with SARS-CoV-2 virus, including inflammation due to the cytokine storm caused by COVID-19 disease ("COVID-19"), and acute respiratory distress syndrome ("ARDS").

OKYO has been developing the chemerin molecule as a promising anti-inflammatory treatment for dry-eye disease ("DED") licensed from researchers at On Target Therapeutics LLC. OKYO has previously announced that it anticipates making an investigational new drug submission with the US Food and Drug Administration for the use of chemerin in the treatment of DED.

"Together with On Target Therapeutics LLC, we have been exploring chemerin and associated analogues for other potential therapeutic uses and are now also focusing on chemerin as a novel approach to treating COVID-19 and ARDS patients," said Dr. Gary S. Jacob, CEO of OKYO. "We are working aggressively to expand this COVID-19 work and will be providing progress on this project as important developments occur."

Dr. Napoleone Ferrara, a member of OKYO's Scientific Advisory Board, will be spearheading this effort at OKYO to advance chemerin and its associated analogues for the treatment of patients with SARS-CoV-2 virus and ARDS. Dr. Ferrara, winner of the prestigious Lasker award and a member of the National Academy of Sciences USA, was the scientist who isolated vascular endothelial growth factor (VEGF), a discovery that led to the two blockbuster drugs Lucentis(R) and Avastin(R) (which together accounted for over US$9 billion in sales in 2019) as well as to the class of anti-VEGF drugs, which are widely used to treat cancer and intraocular neovascular diseases.

Dr. Ferrara commented: "We are very excited to be working with our collaborating industry and academic partners to develop this promising addition to the COVID-19 therapeutic armamentarium and, of course, to expedite evaluation in patients as soon as possible. Beyond COVID-19, chemerin, which is a well-established modulator of inflammation, has promise for treating ARDS, a pathological condition that may be triggered by a host of insults to the lungs (e.g., pneumonia, sepsis, pancreatitis and inhalation injury)."

About Chemerin and its receptor: The chemerin receptor ("CMKLR1", also known as ChemR23) is a chemokine like G protein-coupled receptor ("GPCR") expressed on select populations of cells, including inflammatory mediators (including macrophages, monocytes, plasmacytoid/myeloid dendritic cells and natural killer cells), as well as epithelial cells. Activation of CMKLR1 by its endogenous peptide ligand chemerin is known to modulate inflammation, but natural ligands for CMKLR1 have short half-lives due to rapid inactivation. Discovery of a stable, high potency CMKLR1 agonist (stable lipidated chemerin) by On Target Therapeutics LLC provided an important step toward the development of a new class of anti-inflammatory therapeutics.

The person who arranged for the release of this announcement on behalf of the Company was Dr. Gary S. Jacob, Chief Executive Officer of OKYO.

Enquiries:

 
                           Gary S. Jacob, Chief Executive 
                            Officer 
                            Gabriele Cerrone, Non-Executive    +44 (0)20 7495 
 OKYO Pharma Limited        Chairman                            2379 
 
 Optiva Securities 
  Limited                                                      +44 (0)20 3981 
  (Broker)                 Robert Emmet                         4173 
 
 RedChip Companies         Dave Gentry                         dave@redchip.com 
  Inc. 
   (Investor Relations)                                         +1 407-491-4498 
 

Notes for Editors:

About OKYO

OKYO Pharma Limited (LSE: OKYO; OTCQB: EMMLF) is a life sciences and biotechnology company admitted to listing on the standard segment of the Official List of the UK Financial Conduct Authority and to trading on the main market for listed securities of London Stock Exchange plc. OKYO is focusing on the discovery and development of novel molecules to treat inflammatory dry eye diseases and chronic pain.

About Dr. Napoleone Ferrara

Dr. Ferrara is a member of The National Academy of Sciences and has received numerous prestigious awards, including the Lasker Award and the Breakthrough Prize in Life Sciences. His research on understanding the role of angiogenesis and vascular endothelial growth factor (VEGF) in cancer development, led to the discovery that VEGF is a key mediator of angiogenesis associated with intraocular neovascular syndromes. This pioneering research led to the clinical development of a humanized anti-VEGF Fab (Ranibizumab, Lucentis(R)), which has also been approved as a therapy for neovascular age-related macular degeneration (AMD), retinal vein occlusion and diabetic macular edema. Ranibizumab and other anti-VEGF agents have had a dramatic impact on the development of therapies for these blinding disorders. When Lucentis(R) (Ranibizumab) received FDA approval in late June 2006, the new macular degeneration drug was celebrated as a major medical breakthrough. Dr. Ferrara's research also led to the development and approval of humanized anti-VEGF mAbs (Bevacizumab; Avastin(R)) for cancer treatment, with Avastin(R) being one of the bestselling cancer drugs over the last two decades. Lucentis(R) and Avastin(R) collectively achieved over $9 billion in sales in 2019.

.

Forward-Looking Statements:

Certain statements made in this announcement are forward-looking statements. These forward-looking statements are not historical facts but rather are based on the Company's current expectations, estimates, and projections about its industry; its beliefs; and assumptions. Words such as 'anticipates,' 'expects,' 'intends,' 'plans,' 'believes,' 'seeks,' 'estimates,' and similar expressions are intended to identify forward-looking statements. These statements are not guarantees of future performance and are subject to known and unknown risks, uncertainties, and other factors, some of which are beyond the Company's control, are difficult to predict, and could cause actual results to differ materially from those expressed or forecasted in the forward-looking statements. The Company cautions security holders and prospective security holders not to place undue reliance on these forward-looking statements, which reflect the view of the Company only as of the date of this announcement. The forward-looking statements made in this announcement relate only to events as of the date on which the statements are made. The Company will not undertake any obligation to release publicly any revisions or updates to these forward-looking statements to reflect events, circumstances, or unanticipated events occurring after the date of this announcement except as required by law or by any appropriate regulatory authority.

For further information, please visit the Company's website at www.okyopharma.com.

This information is provided by RNS, the news service of the London Stock Exchange. RNS is approved by the Financial Conduct Authority to act as a Primary Information Provider in the United Kingdom. Terms and conditions relating to the use and distribution of this information may apply. For further information, please contact rns@lseg.com or visit www.rns.com.

RNS may use your IP address to confirm compliance with the terms and conditions, to analyse how you engage with the information contained in this communication, and to share such analysis on an anonymised basis with others as part of our commercial services. For further information about how RNS and the London Stock Exchange use the personal data you provide us, please see our Privacy Policy.

END

MSCGPURUGUPGGPR

(END) Dow Jones Newswires

January 19, 2021 02:00 ET (07:00 GMT)

1 Year Okyo Pharma Chart

1 Year Okyo Pharma Chart

1 Month Okyo Pharma Chart

1 Month Okyo Pharma Chart

Your Recent History

Delayed Upgrade Clock