Microsaic Systems Share Discussion Threads

[splatted] 07/1/2018 17:55

Bloodyell moneymunch ;-) we know how to research. If someone doesn't then no reason to make it easy for them.wouldnt want them in this anyway atb

[moneymunch] 07/1/2018 14:05

Product News: Miniaturised Mass Spectrometer is Enhanced to Enable Real-Time Analysis of Proteins in Bioprocessing Applications

12 May 2017

Microsaic Systems plc, the developer of chip-based mass spectrometry (MS) instruments, has developed a novel technology to enable real-time analysis of proteins in bioprocessing applications, such as in the manufacture of biologic molecules (proteins, antibodies and peptides) for therapeutic and diagnostic uses.

The new technology is a tool for rapidly desalting and purifying protein samples prior to their analysis using Microsaic’s 4000 MiD® MS instrument. This new technology has the potential to significantly accelerate the industrial purification of biologics.

Glenn Tracey, Microsaic’s Chief Operating Officer, commented: “The benefits of Microsaic’s point of use MS technology, in combination with its patented innovation for on-line desalting, allows for the purification of the desired biomolecules in real time. In doing so, analysis times can be reduced from days or even weeks to minutes while offering the potential for significant savings on operational costs. Eight of the top ten selling drugs in 2016 were biologics and the trend for targeted biologic therapeutics is set to continue. Technologies that can accelerate and enhance their production therefore present an opportunity for Microsaic.”

Mass spectrometry is a powerful technique which allows the effective implementation of “QbD” (Quality by Design), a key industry and regulatory driver for current and future production of biologics.

[moneymunch] 07/1/2018 13:47

Cheers Spawny...Gl ;-)

Please note. More articles may be available for subscribers only.

Microsaic

January 2018

There is often a dash for bombed out shares around the turn of the year. This year is the turn of Microsaic (MSYS; 3.8p), down from a float price of 47p in 2011. The company, which has developed the world’s smallest mass spectrometer, is a spinout from Imperial College..................

[spawny100] 07/1/2018 13:02

Tipped as secondary recommendation in scsw this weekend edition. Should see some buying here tomorrow

[guyswonga74] 07/1/2018 12:55

Need a good push to break that 4.5p resistance. Hopefully tomorrow

[moneymunch] 06/1/2018 16:06

5p plus this coming week looks nailed on imho.... Gla ;-)

[splatted] 06/1/2018 14:29

Don't expect to see a commercial instrument just yet ( he says 3 years ago) ;-)

[gismo] 06/1/2018 11:08

Thanks guys, hi short, oh don't worry, I won't mention this share only by pm to those who are worth sharing! The language over there is atrocious, even by my standards!

Just read their website, looks very sound and interesting...

Good luck everyone!

[guyswonga74] 06/1/2018 11:01

Still a good time to buy in here

[moneymunch] 06/1/2018 10:53

Good luck Gismo and cheers Bill....Micosaic also have other products in the pipeline, as highlighted by the following extract from their Interim Results September 2017 and the following article from March 2015 which details the potential of their Quadrupole Mass Spectrometer which is presumably a few years further down the road in its development. Gl ;-)

28/9/17


Technological enhancements

The Company has a compelling product development pipeline in support of its bioprocessing applications and in maintaining its leading position in miniaturised MS instruments and technologies. Such enhancements aim to further extend the mass range for biologics detection, and introduce new capabilities, such as on-line desalting, which allows for the purification of biomolecules in real time. In doing so, analysis times can be reduced from weeks to hours, which offers the potential for significant savings in operational costs of bioprocessing.

The Company has also developed a working prototype of a miniaturised "triple quadrupole" instrument, and is welcoming interest from partners for further product development and channels to market for this technology, in life science applications.


Volume 93 Issue 10 | p. 8
Issue Date: March 9, 2015 | Web Date: March 5, 2015

Shrinking The Triple Quadrupole Mass Spectrometer
Instrumentation:

Researchers develop the first miniature analyzer for mass spec’s quantitation workhorse

The ion optics bench of a miniaturized triple quadrupole mass spectrometer.

The first miniature triple-quadrupole mass analyzer is not much longer than a pencil.


To uncover the molecular composition of samples outside the lab, researchers have been shrinking mass spectrometers to make them portable. Various mass analyzers—the components of the spectrometer that sort molecular fragments and send them into the detector—have already been miniaturized, including ion traps and single quadrupoles. But triple quadrupoles, the mass analyzers of choice for most quantitative mass spec applications, have not been miniaturized—until now.

A team at Microsaic Systems, in Woking, En­gland, has developed the first mini triple-quadrupole mass analyzer (Anal. Chem. 2015, DOI: 10.1021/acs.analchem.5b00311).

The work “marks important progress in mass spec miniaturization,” says R. Graham Cooks, a chemistry professor at Purdue University. “Almost all previous miniature mass spectrometers have used ion traps.”

“The mass spectrometer for targeted compound quantitation is the triple quad, whether the application is environmental monitoring, food safety, clinical analysis, or whatever,” says Richard A. Yost, a chemistry professor at the University of Florida. “This is really the first commercial attempt to develop a practical small-sized and potentially field-deployable triple-quad platform.”

The overall mass analyzer is about 9.5 inches long, about one-quarter of the size of those used in conventional triple-quadrupole instruments, according to Steven Wright, the Microsaic scientist who led the development. The researchers demonstrated the analyzer’s abilities by coupling it to a liquid chromatograph and by using it to perform both single-stage and tandem mass spectrometry.

Microsaic wants to use the mini analyzer for field applications such as food analysis, including the detection of pesticide residues on apples. “We’ve shown that we can detect pesticides at 10 ppb,” a desirable level of detection in pesticide monitoring, Wright says.

But don’t expect to see a commercial instrument just yet. “There’s a great deal of system engineering to do,” Wright explains. “We have the core of the system. The physics works, and we’ve got the performance, but now we have to build a system around it.”

[billthebank] 06/1/2018 10:32

Nice summary moneymunch

[gismo] 06/1/2018 09:54

Hi moneymunch, thanks so much for the update on this share. I will be a holder, hopefully sometime this week! Have a great weekend, Gis

[moneymunch] 06/1/2018 09:47

Hi Gismo, hope you're well...the momentum is definitely upwards, although with so few shares in circulation the share price will be volatile in both directions ( and so be prepared ) but no doubt there must be plenty who will have wished they'd held on to their shares over the last few weeks with the share price closing above 4p plus......there are only 181m shares in issue and the majority are held tightly by institutional investors and it's estimated that there maybe only 40m in free float....Microsaic's market cap is only £7.6m and it's reckoned they have c£3m cash in the bank, and they already have an existing revenue stream from their established customers and OEM's from the sale of instruments and consumables , which are anticipated to be much better than H1 2017 trading conditions, and so a positive trading statement on H2 2017 revenue streams will no doubt add value....their minaturised mass spectrometry technology appears to be cutting edge, which is highlighted by the research agreement with their global biopharma partner which is already validated by their partners BIG pharma end user customers, and so successful trials in the coming weeks and months and disclosure of their partner and subsequent productisation and commercialisation will be a game changer and will see the share price many multiples from its current low imho...the appointment of Peter Grant to the Board, Syepharma's ex CEO speaks volumes, he was instrumental in Skyepharma's stunning development and subsequent £440m merger with Vectura and must have many industry contacts and influence that could be highly beneficial to Microsaic's fortunes....their current prospects and potential are looking very attractive for some serious upside, with very little downside if all goes to plan imho and so i intend to be invested for the long term......Good luck. ;-)

[gismo] 06/1/2018 08:19

Thank you 2P

[2prsimo] 06/1/2018 08:17

I think the first staging post has to be a completion of the bowl on the 2-year chart. So 20p would be the first target within the next six months or so. GLA

[gismo] 06/1/2018 08:12

Good morning mm, found you! Thinking of buying in next week, if it's not too late, waiting for funds to be released. Where do you see this heading, just a guesstimate tks Gis

[moneymunch] 05/1/2018 21:49

A positive trading update/statement will add further value...but the real upside...the multi-bag ahead...the prize that we are all awaiting, is what we're all looking forward to...Gla holders...On and Up!!! :-)

Disclosure of Microsaic's global biopharma partner with their global reach, which is expected in the coming weeks and months, will see the share price many multiples of the current price on successful trials and commercialisation imho......in the meantime with so few shares in circulation and most held tightly...this will continue to re-rate and re-rate in anticipation...Gl ;-)

13th December 2017

Q&A with Glenn Tracey Chief Executive Officer at Microsaic Systems PLC (LON:MSYS) Microsaic Systems plc

Q&A with Glenn Tracey Chief Executive Officer at Microsaic Systems PLC (LON:MSYS)

Microsaic Systems PLC (LON:MSYS) Chief Executive Officer Glenn Tracey caught up with Directors Talk for an exclusive interview to discuss the research agreement with a global biopharma partner, the meaning of a biopharmaceutical, the biologics market and why they are seeing the need for in-process mass spectrometry for biologics that perhaps they wouldn’t see for traditional drugs.

Q1: Microsaic recently announced the signing of a research agreement with a global partner in biopharma, can you tell us a little bit more about that?

A1: Yes, absolutely so I’ve got to say that we are under strict NDA in this particular case but what I can do is give you some context. Earlier in the year we successfully completed a significant joint feasibility phase to show dedicated at-line mass spec can assess the quality of biologics during the manufacture.

I think perhaps the most important aspect of that phase was that we had substantial end-user validation from big pharma and just to say that these are end-users whom our partner has very good global reach.

What this new phase is it will bring more end-user validation to the approach, but I think the exciting deliverable is that we’ll be able to provide a lot more technical integration with the partner’s product.

So, should this activity be successful, it will take us into the second half of 2018 and then that will proceed a period of productisation. As I said, I can’t give any details yet about the size and timeline for commercialisation, but the opportunity is significant to us, to Microsaic, and delivery is proportionate, I would say, to our timescales.

hxxps://www.directors talk/microsaic-systems-plc-qa-ceo-glenn-tracey-lonmsys-2/412742383

[moneymunch] 05/1/2018 21:21

Only 5.43m shares required for declaration of 3% threshold, and so every chance. Gla :-)

Ps those waiting for a nibble sub 3p are going to be greatly disappointed ...Ho Ho Ho.... Gla holders...On and Up!!!;-)

[splatted] 05/1/2018 17:46

TR1 seems logical. News leaked and ready for us at 7 on monday

[jungmana] 05/1/2018 17:34

Thanks mate. Cant wait for next week here

[billthebank] 05/1/2018 17:20

Jungmana Good shout re PYC v MSYS Good luck Might message yoj fir youf thoughts re PREM!!

[jungmana] 05/1/2018 17:16

TR1 on the way imo. Someones been buying in 250k blocks. Could be our new chairman.

[moneymunch] 05/1/2018 16:28

Perfectly poised...;-)

[2prsimo] 05/1/2018 16:27

chart looks primed

[moneymunch] 05/1/2018 16:27

4p plus.....5p plus plus this coming week imho....Gla ;-)