Gsk Share Discussion Threads

[buywell3] 17/2/2018 19:39

Alzheimer's Disease and Prion Protein

Alzheimer's disease (AD) is a devastating neurodegenerative disease with progressive loss of memory and cognitive function, pathologically hallmarked by aggregates of the amyloid-beta (Aβ) peptide and hyperphosphorylated tau in the brain. Aggregation of Aβ under the form of amyloid fibrils has long been considered central to the pathogenesis of AD. However, recent evidence has indicated that soluble Aβ oligomers, rather than insoluble fibrils, are the main neurotoxic species in AD. The cellular prion protein (PrPC) has newly been identified as a cell surface receptor for Aβ oligomers. PrPC is a cell surface glycoprotein that plays a key role in the propagation of prions, proteinaceous infectious agents that replicate by imposing their abnormal conformation to PrPC molecules. In AD, PrPC acts to transduce the neurotoxic signals arising from Aβ oligomers, leading to synaptic failure and cognitive impairment. Interestingly, accumulating evidence has also shown that aggregated Aβ or tau possesses prion-like activity, a property that would allow them to spread throughout the brain. In this article, we review recent findings regarding the function of PrPC and its role in AD, and discuss potential therapeutic implications of PrPC-based approaches in the treatment of AD.

[montyhedge] 17/2/2018 10:35

On the day ex div, a nice positive rns and the shares won't fall by the ex div amount of 23p next week.

[chessman2] 16/2/2018 18:05

At the present level this is great value so I've added another 1000 shares to my bucket.

[ny boy] 16/2/2018 16:38

This time the turnaround could be for real! Anyway happy to collect the quarterly divi, over 6% pa, better than down at el banco

[abdullla] 16/2/2018 16:31

Yes,for investors who are new to GSK it would be a good opportunity to pick up shares at bargain prices on ex- div day.!

[montyhedge] 16/2/2018 16:12

Like I said 1355p before ex dividend next week. I have seen GSK go ex 19p but gone up.
Could it happen again.

[romeike] 16/2/2018 13:31

It is possible Warren Buffet has made buying pharma stocks acceptable again?

[ygor705] 16/2/2018 09:32

SP looking perkier this morning!

[montyhedge] 16/2/2018 08:05

Should have a run up to ex div next week 1355p, div 23p of course, but I don't think it will fall that amount, probable 15p.

[abdullla] 15/2/2018 16:03

Finger crossing didn't work,but you can't say we didn't try,back to the future or shall I say past !

[romeike] 15/2/2018 13:55

Maybe if we all cross our fingers we can finish up over £13.

[alphorn] 15/2/2018 12:41

Monty - did you red tick me? You will remember from my post that there are some strange things around Lupuzor.

[montyhedge] 15/2/2018 12:20

Nice 23p dividend for this quarter in the bag, ex div next week.

[montyhedge] 15/2/2018 12:18

I think IMM will flop shareprice telling you that, no competition for GSK I reckon.

[alphorn] 15/2/2018 10:01

No news yet from IMM on Lupuzor.

[tradermichael] 15/2/2018 09:57

I understand that Merck's Consumer Healthcare may also be up for grabs ......

[montyhedge] 15/2/2018 09:43

I hope we win, easily raise money in the bond market, dividend safe in my view.

[montyhedge] 15/2/2018 09:41

I think next week. Bids had to be in 1st Feb, think there was only two. Lol it's either yes or know.

[badtime] 15/2/2018 09:37

LOL ..first of many

[abdullla] 15/2/2018 09:16

Until then the GSK share price will bleed but slowly !

[tradermichael] 15/2/2018 09:10

For Pfizer Consumer Healthcare, there is the possibility of a deal to be finalized by mid-year, 2018.

[juju44] 15/2/2018 09:02

back in again . Techs still saying BUY

[bilster1] 15/2/2018 08:59

Hi Monty - when do you think this will be?

[montyhedge] 15/2/2018 08:49

Should be hearing about the bid shortly.