Share Name Share Symbol Market Type Share ISIN Share Description
Evgen Pharma Plc LSE:EVG London Ordinary Share GB00BSVYN304 ORD 0.25P
  Price Change % Change Share Price Bid Price Offer Price High Price Low Price Open Price Shares Traded Last Trade
  0.00 0.0% 7.45 7.30 7.60 7.45 7.45 7.45 0.00 08:00:00
Industry Sector Turnover (m) Profit (m) EPS - Basic PE Ratio Market Cap (m)
Pharmaceuticals & Biotechnology 0.0 -3.1 -2.7 - 10

Evgen Pharma Share Discussion Threads

Showing 1576 to 1599 of 1850 messages
Chat Pages: 74  73  72  71  70  69  68  67  66  65  64  63  Older
DateSubjectAuthorDiscuss
23/9/2019
20:28
And in a blinded trial there won’t be any news ‘slipping̵7; out so don’t worry about that.
nobbygnome
23/9/2019
20:26
>> Pennyfalls So many questions. First of all I mean they have been clever with the choice of endpoint which increases the chance of a positive result. However of course going forward all that really matters is whether there is a reduction in mortality. My nervousness is more a gut feel born out of many years in the industry and many years investing in biotech. Plus as I said earlier SAH is a difficult indication where little has been shown to work. You have to understand that I have a high propensity for risk and had a big holding ahead of the breast cancer trial. Luckily I sold the majority on the day of the results in the high 20s but that really was more luck than judgement. So I am certainly not going all in this time but still may buy a few more just in case my nervousness is misplaced. Ultimately please DYOR and I may well be completely wrong and will be the first to point that out if there is a positive result. Unlike most on this board, I say it as it is even when it is against my own (small) holding!
nobbygnome
23/9/2019
19:57
Indeed Dave.. And Nobby...could you expand on why you feel they’ve been canny with the endpoints? Also, if you feel “unease” is PIs getting nervy or that data could be slipping and whispers coming out? If people are getting nervy, why would that be now, and wouldn’t the larger investors be de-risking their position? And, Nobby, what is your thought process regarding buying more if you feel the risk profile is high, with an increasing nervousness? Thanks..all good stuff
pennyfalls
23/9/2019
19:50
I would be surprised if the company had not entered into a meaningful trial.
dave444
23/9/2019
19:44
Ok nobby, interesting thoughts. I see you have quite a lot of experience in this sector, so value your opinions. I’d appreciate it if you expand a little on what you’ve said if you don;’t mind.. Just wondering out loud what other endpoints regarding efficacy they could have chosen? If they’ve been cute does that mean if may have a limited outcome?...and does having “limited”; risk endpoints mean that it could be a rather muddied result..ie it meets endpoints as stated but isn’t enlightening or wold shaking? Ie a technical success, but of limited use? Thanks...very interested Anyone else got a view on this? What are rating the chances of success at, in your view?
pennyfalls
23/9/2019
19:04
My personal thought is that there is some nervousness about the SAH result and that is exactly my position. SAH is a difficult indication although they have been cute by having the primary endpoint of this trial as blood flow rather than another efficacy end point. So overall high reward but high risk IMHO. I only currently have a small holding but am considering buying a few more whilst being fully aware of the relatively high risk.
nobbygnome
23/9/2019
18:44
Hi there...Thanks for your post LWHL ;o) can’t you change usernames? Maybe re-register( yes, a pain!) Thanks for posting and opening up to lacking confidence. Message boards can be brutal places - usually the ones who are insecure themselves, or have too much invested/ ideologically defensive about a stock are the worst ones..but then there’s the sharks, the rampers/deramper s etc etc..It’s a minefield, and it still gets to me sometimes, despite my experience in investing. So, I say, please carry on and air your views, and try to turn a blind eye to criticism. Share boards are for sharing views and information, ideas, speculation and tips. You’re correct in that the last to know of bad news will be PIs, but in some ways all you can do is extrapolate the story and follow the money. This is a VERY typical share graph pattern , and hopefully , should stabilise v soon (I think we’re about at bottom now) and Moving Averages start going positive, then it’s game on. It also looks like a tipping point in commercialisation - 50 to 250M upfront etc if those goes well last Quarter. Following the money: It’s hard to know what all these (somewhat disconcerting)sells are circa £11K,, may mean something may mean nothing, may be MMs buying ans selling to each other to create fear) So...all we have is reading between the lines of Company Progress (all seems to be good), and Big investors...ie Ali Mortazavi And Richard Griffiths.. They know each other of old, and are very successful, clued-up Investors/ ex CEOs, one a Biotech specialist. They’ve plumped in here quite big circa placing and around that time. I would think that they are very informed of what’s going on here and have more idea than the average punter. Shorting doesn’t appear to be their game, so I’m taking their involvement to be very positive. But, as you say - it’s all playing the odds... Good luck and please keep posting
pennyfalls
23/9/2019
16:06
It is a rubbish username; I wanted something more snappy, but in the end just plumped for this, as the creative juices were not flowing! I appreciate your comments Pennyfalls and they are similar conclusions to my own here, although I am not as knowledgeable as a lot of posters on these boards and therefore lack the confidence to put some of my opinions in writing too. Some of the commentators on these boards are so extreme as well, it can feel a bit like being back in the classroom and not wanting to incur the scorn of the popular kids:) I continue to ponder whether I should add to my (small) current holding here, but irrespective of this decision, I have decided not to sell any and see this through to its conclusion. I have witnessed both ends of the spectrum with other similar stocks (as a non-holder) and so am aware that disastrous results will mean I will not escape with much of my initial investment before the big boys have fled first anyway, and if positive news, a multi-bagger from here does not seem to be unrealistic, from various things that I have read, IMO of course.
lovewinshatelosses
23/9/2019
14:39
Hi lovewinshatelosses (that;’s quite an extended name!) In my opinion the MMs have this on quite an obvious chart trajectory down to a support of between 15 -16p, then I think they’ll start raising it a little in anticipation of Q4 news, when, if good, they’ll release it. I think some of today’s news was already factored in and I think they’re waiting for the Q4 update to let it go (either way, depending on results) I’ve no idea if they’re share accumulating in the background or at least trying to... There does seem to have been a drip selling going on (but some were buys tagged as sells - and there have been a few substantial buys too) Think we’ll know the answers in a few days/ weeks
pennyfalls
23/9/2019
12:46
So, another positive RNS and yet no great movement in the share price today so far. Do people think that this is because the statistical significance is yet to be proven on a large enough scale and/or for a long enough time period, or is it something else? Regardless, I too would like to add my best wishes to blakeysangel, whose positivity I really respect and whose updates I appreciate.
lovewinshatelosses
23/9/2019
10:54
Good to hear that you are still long and strong blakeysangel, your positive outlook is an inspiration. With an (indirect) individual mention in this recent RNS, I suspect your case will also be mentioned in the subsequent publications regarding the trial, therefore securing an immortal place in the annals of at least one learned Oncology Journal.
timbo003
23/9/2019
09:04
>> Blakeysangel I think your positive thinking is part of the story too! Keep it going. You are an inspiration to all of us.
nobbygnome
23/9/2019
08:30
Dear Blakeysangel, thank you so much for coming on here and sharing. I’m chuffed for you that it seems to be helping and hope you stay as well as can be. I think a healthy diet does make a massive difference.. I’ve been taking grapeseed axtract among other flavanoids etc, and some of these have had remarkable effects in studies, so I do thkink that getting potent high-powered anti-oxidants among a balanced diet can work. I should have had cataract development within 3 years after an eye operation 10 years ago, but I”ve made sure I have high reservatrol intake , Quercetin , Cyanadins, etc..and still no sign of one. What we put into ourselves does make a difference. Great to hear from you, and thanks for sharing, and long may you stay healthy :o) Xx
pennyfalls
23/9/2019
07:05
So I made my goal of being the longest on this drug, so far, I’m ecstatic and pleased for all the others who have had success and are still continuing,one of the main bonus,s for me has been the mild side effects, my quality of life is very good. My hubby pointed out that maybe my diet choices over this time have helped also,I still continue to eat lots of broccoli and greens and a good diet, with a few naughty bits thrown in to keep me on track, who knows with this disease. Anyway here’s to another 6 weeks progression free till next scan.😀ԅ12;
blakeysangel
23/9/2019
06:29
Excellent news. Presentation in Barcelona 29.09.19.
snowyflake
23/9/2019
06:18
Excellent news. For success in the next trial they are hoping for 8 months of PFS. To have 5 people demonstrate success for over 12 months most be encouraging. And as the news release states you would hope for even better results when given at an earlier stage. I wonder why they released this news now. Perhaps to share with potential partners.
pdt
23/9/2019
06:13
Brilliant result in that RNS
dave444
20/9/2019
09:57
Hello again, There’s a poster on LSE called Greg25 who seems really clued-up about Evgen. Does he post on here? Thanks
pennyfalls
19/9/2019
18:53
Ps Looks like my weird tick-down troll from NFX is following me around again! (Unless it was just a deservedly bad first post!)
pennyfalls
19/9/2019
11:39
Morning all... Just bought in here this morning. Looks very promising indeed. I’ve been reading about this for last 3 days, including Blakeysangel’s kind input - and I hope things go well for you. Very heartwarming. I love how this drug has potential not only in Cranium bleeds, but autism, cognitive function in mental illness and obviously cancer. Potent thing those Broccoli phytochemicals :o) The chart is looking primed for a breakout and news (in next few weeks) will probably be catalyst, although it may nudge up before then. Gap in chart today to be filled circa 16.15- 16.20 ish. Thanks everyone for an informative and level-headed board, and please share more info. Thanks and good luck, PF
pennyfalls
12/9/2019
21:06
Blakeysangel - thanks for keeping us informed and hopefully SFX-01 will keep working for you for a long time to come. Enjoy the seaside, incidently I live on the coast looking out over water and love it.
pdt
12/9/2019
20:33
Thanks everyone for your support. It’s interesting ,PDT ,that the next trial is at a earlier stage, 2nd line treatment after CDK4/6, I’m yet to have a CDK4/6 as I’m on tamoxifen so perhaps if things do progress I maybe able to drop on a trial again with STEM in partnership with a different treatment. PDT I’ve been on the trial since early June 2018 and won’t be scanned again till November at the earliest.Till then the seaside and enjoying early retirement is what I’ll be doing 😀😀.
blakeysangel
12/9/2019
13:17
diamondstar1 - in these cases they are trying to increase rather than inhibit NRF2. SFX-01 is sulforaphane based and one of the unique properties is that it crosses the blood brain barrier and being in the SFX-01 formulation it is stable and suitable for clinical studies. There were some studies into the analogues and SFX-01 was the most potent NRF2 activator for use in SAH. There are other companies with NRF2 activators such as Reata Pharma (US) and C4X (UK) has an early stage molecule. There are some links on Evgen's website re action of SFX-01 and Multiple Sclerosis.
pdt
12/9/2019
12:06
Thanks PDT - you are perfectly right. There was an announcement on 28-Aug-2019, that the last patient had achieved final study visit. Add 6 weeks to this - and the results could be released as early as mid October, or possibly late Oct as you suggest. PDT - do you understand the key differences between NRF2 inhibition with SFX-01 and other NRF2 inhibitors e.g. Biogen’s marketed product for relapsing-remitting multiple sclerosis?
diamondstar1
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