Evgen Pharma Share Discussion Threads

[jusjusjus] 01/10/2020 13:47

so we have a buyer!

by 11:46 we had 605k of sells, seems the buyer took most of them for a premium

(wondered why the bid was holding up)

[moneymunch] 01/10/2020 11:50

Cheers wanobi, Evgen is all set for a significant re-rate or two as good news rolls in from this current bargain low....SFX-01 in evaluation for multiple disease targets with high profile academic researchers, with phase 2b trials for breast cancer in the planning as well as the phase 2/3 Covid-19 trials....the current lowly market cap does not reflect true and fair value of the current development status of SFX-01 , especially with similar stage Bio's valued at $100's of millions....and so hopefully the new CEO will be the catalyst for full appreciation and significant and substantial returns....BIG pharma could also be a pivotal factor in proceedings. Gl :-)

[wanobi] 01/10/2020 11:35

many thanx mm, pogue and others here,,, really appreciate you sharing your hard work with us all, cheers Wan :-)

[jusjusjus] 01/10/2020 11:33

bid holding up well to the selling!

[pogue] 01/10/2020 11:21

Public Health announcement
One for the investors here that eat broccoli as well as invest in it. You get 10 to 100 times more Sulforaphane in broccoli sprouts than the mature veg apparently. This may help those of us who struggle with eating the mature raw version, Bumpa. I am about to buy my first pack of the seeds to sprout my own, from ebay they have the cheapest, however the small peppery sprouts look a lot easier to eat I am going to mix them in salads.
Here is a video of a deranged American, aren't they all, showing how to make the aforementioned sprouts.

Announcement ends

[moneymunch] 01/10/2020 10:15

Prof Chalmers..lead investigator for SFX-01 Covid-19 patient trials. Gla :-)

James D Chalmers

@ProfJDChalmers

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2h

Current R0 estimate in Scotland is 1.2 to 1.6 (approx. 3.7 in March/April). Anything above 1 means cases continue to rise. The best option is to get the number below 1 - that means sustainable control of the virus. A circuit break means a temporary drop to 0.5/0.6

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James D Chalmers

@ProfJDChalmers

·

2h

Nice to talk to #bbcgms

@BBCScotlandNews

about the latest COVID19 figures in Scotland. The problem with a "circuit break" i.e temporary lockdown is that its an acknowledgement we can't control the virus. Likely therefore to mean more "circuit breakers" e.g over Christmas

[bumpa33] 01/10/2020 10:13

JusJusJus - you’re welcome.


What still intrigues, and annoys me - is why the secrecy on who has taken the stock/position here?

[jusjusjus] 01/10/2020 10:05

thx Bumpa & mm

[moneymunch] 01/10/2020 10:02

Yep....:-)

Original articleOpen Access

Published: 03 July 2020

Sulforaphane alter the microbiota and mitigate colitis severity on mice ulcerative colitis induced by DSSYan Zhang, Luxuan Tan, Chao Li, Han Wu, Dan Ran & Zhenyu Zhang 

AMB Express volume 10, Article number: 119 (2020) Cite this article

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Abstract

Sulforaphane (SFN) is a kind of natural isothiocyanate, which exists in cruciferous plants. Only few studies were about the anti-inflammatory effects of sulforaphane in ulcerative colitis. In this study, our purpose is to explore the effects of sulforaphane on the intestinal microbial community of UC mice. The severity of mice colitis were measured by colon length, survial rate, body weight and disease activity index (DAI) score. Histological and morphological evaluation of colon tissues were performed by HE. 16S rRNA gene amplicon pyrosequencing was used to analyza the changes of mouse flora. The variety of flora expression were explored using quantitative PCR. Sulforaphane treated mice had larger body weight and longer colon length than DSS-induced mice. The colon tissues of DSS group showed congestion and edema. Meanwhile, treatment with sulforaphane effectively reducted the damage scores and MPO activity. Sulforaphane reversed DSS-induced gut dysbiosis. Sulforaphane would shift the balance to Butyricicoccus on inflammation. The possible anti-inflammatory mechanism of sulforaphane is to coordinate with the probiotics such as Butyricicoccus. In summary, these findings proved that sulforaphane might be a useful content and serve as a potential therapy in the treatment of UC.

Introduction

[bumpa33] 01/10/2020 10:01

I think there has been research on the benefits of sulforaphane in colitis and crohns diseases.

[jusjusjus] 01/10/2020 09:58

intestinal inflammation must also be an application for SFX-01, has that been documented?

[bumpa33] 01/10/2020 09:55

all the clues are there mm. I’m pretty certain at least 20% of the company changed hands over the last 5 months so clearly there’s someone else out there who agrees. A sniff from the Covid trials will send this into orbit and I’m very hopeful that SFX-01 will prove effective because of what we know from the evidence already out there. Let’s see.

[moneymunch] 01/10/2020 09:47

Cheers Bumpa, it's all good and highlights EVG's undoubted Transformational UPside potential. Gl :-)

[bumpa33] 01/10/2020 09:39

There is of course the matter of the role of Stat3 in regard to Cytokines...

“STAT3 plays an important regulatory role in the process of cellular immune responses, antagonizes the release of cytokines, such as IL-12 and IFN-γ, from Th1 cell, and regulates the development and differentiation of T helper cells, such as Treg, Th1 and Th17 [7–9].”

[bumpa33] 01/10/2020 09:28

Nice find mm.

We know that SFX-01 is efficacious in Stat3 inhibition and the activation of Nrf2 from the breast cancer trials. The key role of stat3 in inflammation, and in turn the huge role inflammation plays in so many diseases, really should highlight the inherent value in SFX-01.

One day the mkt will see this. And value us accordingly.

[notknowing] 01/10/2020 09:27

Re-rate in progress. M-Cap should be circa 100M.

[jusjusjus] 01/10/2020 09:25

seller still with us

technically bouncing nicely off the support line

[brasso3] 01/10/2020 08:57

Also added.

[moneymunch] 01/10/2020 08:56

Cheers Jusjusjus and stockhunters , this can only increase SFX-01's profile and interest from BIG pharma imho...Gl :-)

[stockhunters] 01/10/2020 08:55

great find moneymunch rns to follow has to be and on that note i have added

[jusjusjus] 01/10/2020 08:48

great research moneymunch

[moneymunch] 01/10/2020 08:37

SFX-01 's STAT3 properties already validated in the outstanding phase 2 breast cancer results that were life changing for some patients and now we have confirmation that STAT3 is the Key to immune system inflammation ...Massive potential and prospects for Evgen and SFX-01...Gla ;-)

[notknowing] 01/10/2020 07:29

Great news. The not RNS nature of this should allow me a top-up opportunity.