Evgen Pharma Share Discussion Threads

[moneymunch] 01/10/2020 07:12

WOW!!!.....STAT3 - Key to immune system inflammation discovered.....it's almost like getting a RNS this morning....Exciting news for Evgen and SFX-01 regardless and must add significant interest from the industry for any drug that is active against STAT3 , let alone NRF2...Gla ;-)

[moneymunch] 01/10/2020 07:00

15/6/20

Barry Clare, Executive Chairman of Evgen Pharma, said: "We move forward with the confidence that the value of SFX-01 as a potential drug that is active against the two key pathways of Nrf2 and STAT3 will become increasingly clear. These pathways are of significance in a range of diseases including cancer, autism and those where oxidative stress is a factor. We therefore believe that the fundamentals are in place to underpin sustainable share price growth and deliver the undoubted potential of SFX-01. On behalf of myself and the Board, I would like to thank our shareholders for their continued support and we look forward to updating the market with positive news in the coming year."

[moneymunch] 01/10/2020 06:57

Health

October 1, 2020 1:49 pm AEST

Key to immune system inflammation discovered

Hudson Institute scientists have discovered the key to how cells turn on inflammation and fight infection, providing the knowledge to potentially reduce or stop destructive inflammation in future.

The finding comes as the world finds itself in the grip of the SARS-CoV-2 viral pandemic, where raging inflammation caused by the body’s overwhelming immune response in some individuals can lead to death and debilitating ongoing symptoms.


“Inflammation arising from our own immune system response is now recognised as an underlying component of almost every disease,” said A/Prof Ashley Mansell co-author of the study published in Nature Communication. “This includes heart, lung, brain and infectious diseases, cancer, diabetes and chronic kidney, liver and autoimmune diseases.

“If we could reduce dysfunctional or exaggerated inflammation, we would reduce the suffering associated with these severe inflammatory diseases.

“Understanding how cells turn on inflammation provides the building blocks to do this, by potentially targeting these pathways to restrain or stop inflammation attacking the body.”

A/Prof Mansell said the discovery was like “finding how turning a key in a car ignition tells the engine to start producing energy to turn the wheels”.

The study found that a protein called STAT3 plays a critical role in communicating signals from surface sensors on the cell (macrophages) , to the cell’s engine room- the mitochondria – that a foreign invader has been identified.

This reprograms the mitochondria to kick-start energy production and usage to generate inflammation, said co-author Dr Dan Gough. “When an immune cell detects an infection, like bacteria, it rapidly changes its metabolism from a resting to an inflammatory state,” Dr Gough said.

“This provides the energy and building blocks to produce chemicals called cytokines, which fight off the infection. This metabolic or energetic ‘switch’ occurs in the engine room of cells – the mitochondria,” he said.

Hudson Institute Director, Professor Elizabeth Hartland said the discovery was pivotal to understanding how certain immune cells adapt their metabolic activity to drive inflammation.

“There has long been a gap in our knowledge of how macrophages take a signal from the cell surface and translate it to the mitochondria. Now, thanks to the work of our inflammation scientists at Hudson Institute, we have an answer to that question,” said Hudson Institute Director, Professor Elizabeth Hartland.

“This missing link is pivotal because it gives us a deep understanding of the signalling events in our immune system’s first line of defence – the inflammatory process. This discovery has big implications for further research into treatments for a wide range of inflammatory diseases.”

[moneymunch] 30/9/2020 20:13

Scottish numbers:

30 September 2020

640 new cases of COVID-19 reported; this is 10.3% of newly tested individuals.

7 new reported death(s) of people who have tested positive

15 people were in intensive care yesterday with recently confirmed COVID-19.

137 people were in hospital yesterday with recently confirmed COVID-19.

15,629 new ;tests for COVID-19 that reported results.

[euclid5] 30/9/2020 19:59

Thnaks for that link - so not too long to wait for the results then?

[moneymunch] 30/9/2020 19:59

Euclid,who know's, but at 11.30p the 3 x 500k trades were at least 20p more than any other trades that day, and one would have thought they were priced as buys imho....and as I said earlier, all in the mix regardless and suggestive of an ongoing share transfer/accumulation....and as far as the Covid-19 patient trials are concerned, there was probably a shortage of patients initially, but that now looks like all has changed with the second wave rearing its ugly head, and so SFX-01's patient trials could be underway or will be very soon. Prof Chalmers website states it started 1/8/20 but still no confirmation of first patients being administered SFX-01, and because it's such a large and comprehensive trial, then obviously full results aren't expected until July next year, but that doesn't mean we would have to wait that long for an update....early reporting would be very likely if the drug was having a positive effect imho...or negative effect for that matter...Gl ;-)

Ps plenty more in Evgen's pipeline which could add significant value, as well as a potential commercial JV at anytime....let's see what the new CEO has to report in due course. ;-)

[on target] 30/9/2020 19:21

https://www.lifearc.org/funding/covid-19-funding/sfx-01/"...The primary outcome of the trial is the clinical status of patients on day 15 based on a seven point scale..."

[bocker01] 30/9/2020 19:07

Euclid, I would expect them to update on progress. Key is the sample size. It’s big. Meaningful information should be available to those in the know fast.

[euclid5] 30/9/2020 19:02

Money M, how do you definately know those 3 x 500k were not sells, you don't know for certain - but I guess it's in the price now anyway

Seen this on the LSE site - so do we have to wait until June 2021 until this trial ends before we know the resuts of SFX-01?

StatusActive: Effective start/end date 1/08/20 → 31/07/21

hxxps://discovery.dundee.ac.uk/en/projects/a-randomized-controlled-trial-of-sfx-01-to-improve-clinical-outco

[bocker01] 30/9/2020 17:13

Just suffering Mesquida! No immunity!

[mesquida] 30/9/2020 16:57

"Never like seeing losses", Bocker ! As a long suffering shareholder in Iofina I would have thought that by now you might have developed a degree of immunity to losses !!!

[jusjusjus] 30/9/2020 16:39

I think when the bid was below 11p the offer was around 11.1, so we have fewer sells than what's being reported

[bocker01] 30/9/2020 16:19

Strength of the pipeline is so important. Good luck to them. Never like seeing losses.

[moneymunch] 30/9/2020 15:17

It's a shame for those investors sitting on a loss ( wherever invested ), but obviously after hitting a market cap of £370m from c£30m or so, then they obviously needed some very good news to sustain and push on, and so the retrace looked inevitable...i've not reasearched SNG and so no idea what else is in their pipeline but i'm sure when they get the green light for the next Phase for their Covid trials, then the share price will bounce big again. Gl ;-)

[peanut100] 30/9/2020 15:00

Shame about SNG

[moneymunch] 30/9/2020 14:46

ps all in the mix regardless, but suggestive of a share transfer/accumulation imho.....and i'll be surprised if there's any significant number of shares left in free float at all, judging by the on-going tading activity of some very large trades that has been going on for months.....hopefully all will be revealed in the coming weeks with the new CEO in place. Gl ;-)

[euclid5] 30/9/2020 14:34

The 2 x 500,000 at 11.30p look like a roll over or a sell

[notknowing] 30/9/2020 11:21

Code 4 = 10 Bagger

[jusjusjus] 30/9/2020 11:21

"4" trade must be an MM signal, you can't buy 4 shares and be offered full price!

[jusjusjus] 30/9/2020 10:42

maybe the transfer is the new CEO taking a healthy position?

nah, that's daft, not before he officially starts

[stockhunters] 30/9/2020 10:28

i am amazed this has not had more interest since the ceo appointment in my eyes it gives the greenlight for an update at this tiny market cap this is one of the smallest available in the sector

[moneymunch] 30/9/2020 10:20

and maybe disclosure on the relentless share transfer/accumulation, which possibly could be suggestive of a strategic investor JV partnership imho...Gla :-)

[jusjusjus] 30/9/2020 10:13

CEO arrives in a few days, hopefully at least an update from him for the interim period closing 30th Sept.

[notknowing] 30/9/2020 10:09

Rerate MKT CAP to 50m then 100M