Eden Research Share Discussion Threads

[supersonico] 05/10/2017 17:58

Nematicidal Compositions and Methods of Using Them
US 20170245497 A1
Abstract
There is disclosed method of killing nematodes comprising the step of applying an effective amount of a nematicidal composition comprising a terpene component and compositions suitable for use in the method. The terpene component is preferably in association with water, either as a solution or a suspension. An excipient may also be included, which is suitably hollow glucan particles which encapsulate the terpene component.



0019]
The current procedure for the elimination of nematodes in agriculture involves treating the soil with methyl bromide (MB). MB essentially sterilises the soil and provides effective control of a wide range of soil-borne pathogens and pests, including fungi, bacteria, nematodes, insects, mites, weeds and parasitic plants. However, MB has a significant negative impact on the environment.

[0020]
Problems associated with MB include:
Eradication of the beneficial soil microflora and microfauna, resulting in elimination of natural biological control and resurgence of secondary pests and diseases. The “biological vacuum” created by the use of potent biocides, such as MB, results in rapid re-infestation of treated soils.
Toxic side-effects on humans, plants (phytotoxicity) and other non-target organisms. This has safety implications with regard to handling MB as any contact with the user would be harmful. There are therefore also major expenses involved with specialist equipment, training and other precautions involved with ensuring that MB is used, handled and transported safely.
MB is associated with the depletion of the ozone layer.
Pollution of the environment, including soil, water and the atmosphere. MB is, in particular, a major pollutant of underground water.
Pesticide residues in agricultural products, creating health risks for consumers and major obstacles to the international agricultural trade. Soil fumigation with MB is known to leave bromine residues in the soil which can be taken up by, and accumulate, in plants. Problems with bromine residues in leafy vegetables, such as lettuce, are quite common. Indeed, in grape producing regions the use of MB is not permitted due to its health implications.

0026]
For the reasons mentioned above, inter alfa, the production and use of MB is being phased out on a global scale. Under the Montreal Protocol 1991, MB use is to be phased out by 2005 in the E.U. and other developed countries, and by 2015 in the developing countries. There is therefore a need to identify suitable alternative solutions for managing soil-borne pathogens, in particular nematodes.

0027]
The inventor has surprisingly found that terpenes are effective in killing nematodes.
[0028]
Terpenes are widespread in nature, mainly in plants as constituents of essential oils. Their building block is the hydrocarbon isoprene (C5H8)n. Terpenes are classified as generally regarded as safe (GRAS) by the Environmental Protection Agency (EPA) in the USA and have been used in the flavour and fragrance industries.

[0098]
It will be obvious to one skilled in the art that the nematicidal use of a composition made entirely of compounds which are GRAS is highly preferable over the use of prior art toxic compositions. Environmental concerns associated with use of the composition will be greatly reduced and there would be no significant problems with accumulation of the product in food crops. Additionally, regulatory approval of the composition in various jurisdictions would not be as difficult to obtain as for a toxic composition, and indeed may not even be required in some instances.

0211]
The results demonstrate the ability of citral alone and a citral and thymol mixture to kill nematodes at low concentrations. Kill rates in table 7 after 48 hours were over 90% for both mixtures at 250 ppm and 500 ppm concentrations. The 125 ppm concentration showed a lower kill rate. The kill rates in Table 8 show high kill rates after 24 hours for concentration as low as 62.5 ppm.

0214]
The purpose of this experiment was to demonstrate that citral selectively kills the harmful root-knot nematodes over saprophagus nematodes, which are not harmful, and indeed may be beneficial to the plant and soil. Such selective killing is a surprising effect that means treatment with terpenes may kill parasitic nematodes, but not eliminate the beneficial micro-fauna in the soil.

[0217]
The results clearly show that citral kills the pathogenic root-knot nematodes at a much higher kill rate than the beneficial saprophagus nematodes. After 48 hrs the kill rate for root-knot nematodes was 100% for all test mixtures, whereas for Saprophagus nematodes it was only 50-53%. The results were not significantly effected by the inclusion of Tween 80.
[0218]
The results demonstrate that terpenes have the ability to selectively kill pathogenic nematodes whilst allowing beneficial nematodes to survive in the soil. This would result in a more healthy soil environment post treatment than a treatment which kills the entire nematode population in the soil. Firstly this is because beneficial nematodes would be present in the soil post treatment, and secondly there would not be a nematode “vacuum” in the soil which could be filled with pathogenic nematodes or other pathogens.
[0219]
It could be expected that at a very high concentration of terpene may result in a higher kill rate of saprophagus nematodes, thus reducing the selectivity of the treatment. Therefore in use in the field the minimum concentration that achieves the desired kill rate in root-knot or other parasitic nematodes may be selected, thus maximising the selectivity.

[supersonico] 05/10/2017 08:14

Would I be right in thinking the use of Mevalone is now subsidized by the French Dept of Agriculture via the CEPP scheme?



Mevalone, Nirka® and Yatto® are officially eligible for CEPP
In its update of August 2017, the Ministry of Agriculture created the new Action Sheet No. 28 on means of controlling various pathogenic fungi of foliage by means of a biocontrol product.
It is therefore naturally that we find our three specialties: Mevalone, Nirka® and Yatto®. The use of these biocontrol solutions based on encapsulated terpenes to fight botrytis of the vine now makes it possible to obtain CEPPs at a rate of 0.25 CEPP per liter sold.







'Alternatives  – such as biological or mechanical methods – are weighted in a matrix and contribute to a distributor’s overall score towards a certified target.  For every missed Certificat d’Economie de Produits Phytopharmaceutiques (CEPP) at the end of the five years, distributors will face a fine, currently set at a symbolically low five euros'.

So this suggests the CEPP is an inducement/ incentive for distributors I think to promote designated types of product in this case Bio control . So not a direct subsidy to buyers but a sanction to distributors by the French Agricultural Dept determining direction of travel.
.............

pArking

[investingisatrickygame] 05/10/2017 07:34

Exactly supersonic......no correlation!

[investingisatrickygame] 04/10/2017 18:03

Eden does need to talk more to the wider investment community about who and what and where they are. Operational success is one thing, but in being a listed plc they need to better communicate their progress and the investment opportunity. If not, why bother being listed?

A long term view is one thing, but everyone has sat on dead money here for the last two years and the share price is not correlating to the business success. The two need to move in closer parallel. Eden needs to find the tools and the people to make that happen.

[northwick] 04/10/2017 15:51

Looks like Eden is out of favour with the private investors

[littlealbatross2] 04/10/2017 14:51

Super....I like the word 'exponential'.There clearly is a vast market opening up for bio-pesticides and Eden is making considerable effort to gain marketshare in crop protection in this area.
I liked the video, especially the Kiwi and the pretty French girls.

[supersonico] 04/10/2017 14:01

La2..Yes indeed, on the way to registration in 29 countries backed by Eastman distribution and PR.. With that and the Bayer deal the word 'exponential' might get banded about.

[littlealbatross2] 04/10/2017 11:37

Super

Your post 2799. Interesting find re Eastman's job in new nematicide product development in S Europe M East.
I was thinking of applying but coming from near Newcastle I would fail the Language requirement of speaking (proper) English.

[supersonico] 02/10/2017 16:53

The Regional Union of Liberal Doctors New Aquitaine (URPS ML NA) and the Association Alerte Médecins Pesticides (AMLP) ask France "not to vote for the renewal of authorization of glyphosate and call for vigilance on endocrine disruptors presumed ".
On 4 October, the European Commission has to decide on the use of glyphosate.
A probable cancerogen
Glyphosate is a systemic foliar herbicide, ie, a non-selective herbicide that is absorbed by leaves and has a generalized action.
URPS ML Nouvelle-Aquitaine and the association Alerte Médecins Pesticides base their request on the report of the International Agency for Research on Cancer (IARC) "which classifies this molecule to the level of probable carcinogenicity. Liberal doctors believe that doubt must always benefit public health.
Moreover, following the decision taken by Europe last summer on the definition of endocrine disruptors, URPS-ML and the AMLP want the notion of suspected endocrine disruptors to be recognized and thus number of products. "

The doctors referred to the precautionary principle and wished to take a more active part in the necessary health education of the population.

[northwick] 01/10/2017 18:44

Powerscroft advised on Friday that they have a plan in place and will execute this over the next couple of months. Wonder if they misfired on day 1.

[northwick] 01/10/2017 18:41

Maybe it harsh, but looks like it even the newly appointed high profile Pr agents, Powerscroft, could not influence any of the weekend press give coverage to Eden and its

[33mick] 01/10/2017 13:52

Join the generation that's saving our bees:

[33mick] 01/10/2017 13:48

Full page ad in the sun telegraph..by..friends of the earth..''Mr Gove, pesticides are harming out bees''
With ''its time our envoro sec backed our bees by committing to a comp ban on neonics in the uk''

[supersonico] 01/10/2017 07:52

Application Development and Technical Service Manager Crop Protection - Southern Europe

Apply now
Date: Sep 28, 2017
Location: Milano, BE
Job description
• Lead the technical development of a new nematicide product in Southern Europe and Middle East.
• Visit and engage potential or existing customers together in conjunction with regional sales and marketing team to determine current and future agchem needs,
• Liaise with research group for technical support and new product development
• Develop in-depth knowledge base of agchem applications and markets
• Detect and develop new business opportunities for new products/customers/markets
• Detect business trends in the agchem market
• Look for cooperation with third parties/universities and for possible acquisition targets
• Provide technical support for regional sales team and customer base, organize trainings when necessary.
.....................................................

[supersonico] 01/10/2017 07:24

The global nematicides market is witnessing a sustainable growth and is likely to experience a considerable growth during the forecast period. Emerging countries mainly contribute to the market growth, specifically from APAC and ROW. APAC is expected to witness a considerable growth mainly due to the support from several governments, overpopulation, and growing demand for crop-based food products.

Increasing adoption of bio-based nematicides
Surging demand in emerging nations
Increasing seed treatment practices driving demand

Increasing adoption of bio-based nematicides;

Bio-based nematicides are generally bacterial or fungal spores along with inert materials. The microbial spores incorporated in bio-nematicides germinate and seize the growth of nematodes. Bio-based nematicides have several advantages such as no residue leftover, no resistance development, and excellent activity. These advantages make them favored in the market.
Ajay Adhikari, a lead agrochemicals and fertilizers research analyst at Technavio, says, "Bionematicides are widely attracting attention as a core part of the crop protection system. The easy availability of raw materials for bio-based nematicides is the key advantage for the segment. The low cost of manufacturing of bio-based products is also increasing their demand and consumer concentration."

Surging demand in emerging nations

The growth potential for nematicides is mostly in the emerging untapped markets such as China, India, Brazil, and African countries. These countries are heavily focused on the development of the agriculture sector of the rural segment. The consumption of nematicides is low in these countries compared with developed nations. The increasing awareness among farmers is expected to lead to a rise in the consumption pattern.
"China and India are the two largest economies in terms of population, having a rural sector of 67% and 44% respectively. These are the key focus market for the nematicides players. The agricultural output of China is 140% higher than India and 68% higher than the European Union. The growing demand for food products, mainly from developing countries is likely to propel the consumption of nematicides for healthy farm yield and to decrease crop loss," adds Ajay

Increasing seed treatment practices driving demand

Seed treatment systems include the application of chemical agents, biological agents, and physical techniques. These treatments help to protect seeds, as well as aid in the growth of healthier crops. They play an important role in the cultivation of pests-free and disease-free crops. Seeds are treated with agrochemicals to improve the environment for seeds, seedlings, and plants.
Crop protection chemicals such as herbicides and nematicides are applied to the seed and during the growth of the crop. The increase in the prices of high-quality seeds such as hybrid and genetically modified seeds, cost efficiency of seed treatment systems, limitations linked to soil structure and temperature on the application of crop protection chemicals, and encouraging government regulations are driving the market growth for nematicides.
..........................................................................

[sandcrab2] 29/9/2017 16:41

JakTard is a troll who makes a nuisance of himself on many of these boards

[redhill9] 29/9/2017 15:54

Jaknife,
You cannot analyse the cash position without recognition of movement in trade debtors/creditors. The £608,000 is net of payables, as I clearly said above. Receivables increased by £757,000, Payables by £149,000 making a net increase in cash due not yet received of £608,000.

As for your assumption about non-payment, that is baseless as I suspect you know. I can't make up my mind whether you are being mischievous or don't actually understand as much as you pretend.

[redhill9] 29/9/2017 14:37

Jaknife,

Two quick points in response:

1. I didn't say Eden hadn't burnt cash, I was disputing your comment that "they will continue to burn cash" which is a crucially different point. One is historic, the other is current/future.

2. In your post you seem to have ignored the net positive increase in Trade Receivables/Payables of c.£608,000 in the first half of 2017 which may be defined as "cash due not yet received", and is rather relevant to any analysis of the cash position, and the projected trend.

Try doing the cash flow projection I suggested based on the last two half years' experience, adjusted of course for exceptionals, and see if you are still so negative about the cash position.

regards,
redhill

[redhill9] 29/9/2017 11:50

JakNife29 Sep '17 - 09:43 - 2789 of 2789 0 1
The numbers show an exceptional one-off profit that will not be repeated. Full-year they will have a loss again. They still burnt cash despite managing to present an "accounting profit" and look like they will continue to burn cash.

Your comment about Eden continuing to burn cash is misrepresenting (or arguably mistating) the truth.

Apart from your attempt to conflate cash burn with accounting profit, if you bother to look at the analysis of cash movements you will have seen cash held has increased over the period by £2.131m. Removing the Sipcam net cash (received for new shares) of £2.363 as, of course, we should does gives a decrease of £0.232m over the six months, split between £0.216m for development expenditure and a mere £0.016m from operations.

However, it's the trend that matters and indicates where your statement about continued cash burn is false. Comparing those ongoing cash movements for first half 2017 with the prior six months (i.e. second half of 2016) where the equivalent figures were £0.155m for development expenditure and £0.319 for operational cash burn shows the situation from the important operational cash flow significantly improving.

Development cash expenditure increasing is hardly surprising considering the expansion that has taken place over the last 12 months, but the reduction to almost zero of net operational cash is truly significant. Try projecting that change forward and you will get a positive cash flow for the remainder of 2017, showing your suggestion that Eden is continuing to burn cash can be seen to be false.

Also worth noting that Trade Receivables (cash owed to Eden which will be mostly for sales activity) have increased materially by £0.757m, as might be expected with increasing sales activity. Trade Payables have increased by ££0.149m, so a net positive of £0.608m cash to be received in due course.

On what are you basing your statement other than your historic prejudice?